A5023180472- Reproductive Biology and Fertility
- Epigenetics and DNA Methylation
- Genetics, Aging, and Longevity in Model Organisms
- Pluripotent Stem Cells Research
- Sperm and Testicular Function
- Pesticide Exposure and Toxicity
- RNA modifications and cancer
- Genetics and Neurodevelopmental Disorders
- Carcinogens and Genotoxicity Assessment
- Selenium in Biological Systems
- CRISPR and Genetic Engineering
- Environmental Toxicology and Ecotoxicology
Children's Hospital of Chongqing Medical University
2023
Chongqing Medical University
2023
Chongqing Maternal and Child Health Hospital
2023
Qingdao Agricultural University
2020
Lactate is present at a high level in the microenvironment of mammalian preimplantation embryos vivo and vitro. However, its role development unclear. Here, we report that lactate highly enriched nuclei early when major zygotic genome activation (ZGA) occurs humans mice. The inhibition production uptake results developmental arrest 2-cell stage, ZGA failure, loss lactate-derived H3K18lac, which could be rescued by addition Lac-CoA recapitulated overexpression H3K18R mutation. By profiling...
Incomplete DNA methylation reprogramming in cloned embryos leads to poor cloning efficiency. Melatonin has been proven improve the development of embryos, however, role melatonin during somatic cell nuclear transfer remains unclear. This work demonstrated that 10−7 M significantly enhanced developmental progress, reduced arrested rate before zygotic genome activation, and upregulated blastocyst embryos. also promoted pseudo-pronucleus formation, increased number, embryo apoptosis through...
Maternal aging is associated with a decline in oocyte quality, which leads to the decreased fertility. Therefore, developing approaches reduce aging-induced deterioration of quality older women important. Near-infrared cell protector-61 (IR-61), novel heptamethine cyanine dye, has potential for antioxidant effects. In this study, we found that IR-61 can accumulate ovaries and improved ovarian function naturally aged mice; it also increased maturation rate by maintaining integrity...
Abstract Postovulatory aging can trigger deterioration of oocyte quality and subsequent embryonic development, thus reduce the success rates assisted reproductive technology (ART). The molecular mechanisms underlying postovulatory aging, preventative strategies, remain to be explored. near‐infrared fluorophore IR‐61, a novel heptamethine cyanine dye, has potential for mitochondrial targeting cell protection. In this study, we found that IR‐61 accumulated in mitochondria reduced aging‐induced...