A5087009968- Tryptophan and brain disorders
- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Neural and Behavioral Psychology Studies
- Stroke Rehabilitation and Recovery
- Advanced Neuroimaging Techniques and Applications
- Mental Health Research Topics
- Advanced MRI Techniques and Applications
- Dementia and Cognitive Impairment Research
- Acute Ischemic Stroke Management
University of Cambridge
2018-2024
West Suffolk NHS Foundation Trust
2024
University of Leeds
2024
King's College London
2024
<h2>Summary</h2><h3>Background</h3> The antibiotic minocycline has neuroprotective and anti-inflammatory properties that could prevent or reverse progressive neuropathic changes implicated in recent-onset schizophrenia. In the BeneMin study, we aimed to replicate benefit of on negative symptoms reported previous pilot studies, understand mechanisms involved. <h3>Methods</h3> this randomised, double-blind, placebo-controlled trial, recruited people with a schizophrenia-spectrum disorder had...
Apathy is one of the most common symptoms following stroke and often associated with worse functional outcome poor quality life (QoL). The trajectory apathy has been previously described, different trajectories have identified. We determined group individual changes in symptomatology from acute phase until 1 year after stroke. also examined association depression disability QoL
Apathy is a common yet under-recognised feature of cerebral small vessel disease (SVD), but its underlying neurobiological basis not understood. We hypothesized that damage to the reward network associated with an increase apathy in patients SVD.
Background In a previous trial we reported that the neuroprotective, anti-inflammatory antibiotic minocycline lessened negative symptoms of schizophrenia compared with placebo over 1 year. The BeneMin study aimed to replicate this benefit and determine whether or not there was associated preservation grey matter, reduction in circulating inflammatory cytokines enhancement cognition. Objectives To efficacy on mechanistic role cognitive enhancing actions. Methods Two hundred seven patients...