A5071261947- Escherichia coli research studies
- Viral gastroenteritis research and epidemiology
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Infant Nutrition and Health
- Urinary Tract Infections Management
- Parasites and Host Interactions
- Autophagy in Disease and Therapy
- Adolescent and Pediatric Healthcare
- Mosquito-borne diseases and control
- Birth, Development, and Health
- Clostridium difficile and Clostridium perfringens research
- Energy and Environment Impacts
- Hepatitis Viruses Studies and Epidemiology
- Neonatal Respiratory Health Research
- Parasitic Infections and Diagnostics
- Maternal and Perinatal Health Interventions
- Gut microbiota and health
- Parasitic Diseases Research and Treatment
- Mitochondrial Function and Pathology
Consejo Nacional de Investigaciones Científicas y Técnicas
2017-2022
University of Buenos Aires
2017-2022
Ministerio de Salud
2016-2018
Administración Nacional de Laboratorios e Institutos de Salud
2016-2018
The aim of this study was to evaluate the effectiveness benznidazole nanoparticles (BNZ-nps) on trypomastigote forms and intracellular infection in mammalian cells primary cardiac myocyte cells. Its also evaluated acute Trypanosoma cruzi Nicaragua mice infection. Trypomastigotes from culture were treated with different concentrations BNZ-nps determine drug concentration that lyses 50% trypomastigotes (LC 50 ). Infected incubated percentage amastigote inhibition. C 3 H/HeN lethal 10, 25,...
Background Chagas disease is a neglected parasitic infection caused by the protozoan Trypanosoma cruzi (T. cruzi) that affects more than 6 million people, mainly in Latin America. Benznidazole still drug of choice many countries to treat it spite its dosage regimen and adverse side effects such as allergic dermatitis, peripheral neuropathy anorexia. Thus, novel, safer, efficacious treatments for are urgently required. Methodology In this study, efficacy orally administered low doses...
Abstract This study evaluated the effectiveness of low doses benznidazole (BNZ) on continuous administration (BNZc), combined with allopurinol (ALO), in C57BL/6J and C3H/HeN mice infected Trypanosoma cruzi Nicaragua strain T. Sylvio-X10/4 clone. Tc N-C57BL/6J was also treated intermittent BNZ (BNZit). The drug therapy started 3 months post infection (pi) chronic phase heart disease progression, followed-up at 6 pi. BNZc monitored up to 12 pi by serology electrocardiogram. These showed severe...
Shiga toxin (Stx2) producing Escherichia coli infections during early gestation may impair placentation through a Stx2 damage of extravillous trophoblast (EVT) cells. We have previously demonstrated that injected in rats the stage pregnancy causes spontaneous abortion by direct cytotoxic effect highly perfused feto-uteroplacental unit. The main aim was to evaluate effects on EVT order understand possible adverse cells pregnancy. Swan 71 and HTR-8 cell lines were used as human models....
The presence of Escherichia coli in the vaginal microbiome has been associated with pregnancy complications. In previous works, we demonstrated that Shiga toxin-producing (STEC) can produce abortion and premature delivery rats toxin type 2 (Stx2) impair human trophoblast cell lines. hypothesis this work was STEC may colonize lower female reproductive tract be responsible for adverse outcomes. Thus, aim to evaluate prevalence virulence factor genes from endocervix asymptomatic pregnant women....
The human colonic mucus is mainly composed of mucins, which are highly glycosylated proteins. normal commensal microbiota has mucolytic activity and capable releasing the monosaccharides contained in can then be used as carbon sources by pathogens such Enterohemorrhagic Escherichia coli (EHEC). EHEC regulate expression some its virulence factors through environmental sensing mucus-derived sugars, but implications regarding main factor, Shiga toxin type 2 (Stx2), among others, remain unknown....