Background Capecitabine (CAPE), an antimetabolite chemotherapy, can induce hepatic and renal toxicity. Melatonin (MEL), a neurohormone, possesses antioxidant, anti-apoptotic anti-inflammatory effects. This study investigated the impact of MEL on capecitabine-induced Methods materials Twenty-five male Wistar rats were categorized into five groups for study. The included control group, MEL10 group (rats receiving daily intraperitoneal injections 5 mg/kg MEL), CAPE 500 weekly CAPE), + 10 group....

The coronavirus disease 2019 (COVID-19) pandemic is spreading rapidly, and its psychosocial impact remains a big challenge. In this respect, quarantine has been recommended, as significant practice, to prevent the given condition. Therefore, present study was determine prevalence rates of depression, anxiety, stress reflect on COVID-19, traumatic stressor event, individuals. This web-based survey fulfilled via an online questionnaire, completed by respondents selected through cluster...

Few cases of B-cell acute lymphoblastic leukemia (B-ALL)-eosinophilia (ALL-eo) association have been reported. The lack or absence blasts in the peripheral blood smear (PBS) along with urticarial rash, fever, arthralgia, myalgia, sweating, and dyspnea are common features this condition. Herein, we report a 16-year-old male patient admitted to emergency department urticaria generalized itching. PBS was examined, eosinophils (90%) were seen different fields. However, blast cells not PBS. In...

Many empirical studies related to social capital have established that there is a relationship between and mental health. However, little research has been conducted evaluate interventions designed improve the level of its impact on health international students. This research, applying quasi-experimental nonequivalent groups design, aimed address gap by examining whether an intervention at building can students Universiti Sains Malaysia. Study findings revealed was effective in developing improving

Abstract Aim Eighty-five percent of ischaemic strokes are caused by extracranial atheromatous lesions involving a narrowing the Internal Carotid Artery so accurate and timely diagnosis is vital for management. The aim this study was to correlate CT angiogram (CTA) ultrasound doppler (US) derived measurements carotid artery stenosis (CAS), with view identify those cases where second modality required reduce potential errors. Method All consecutive US CTA examinations performed in 2021 2022...

Primary pulmonary leiomyosarcoma (PPL) arises from smooth muscle tissue, with less than 0.5% incidence among malignancies and 30% primary sarcomas. Here, we present a case of PPL managed pazopanib. Moreover, brief review relevant literature was conducted. A 65-year-old female presented chronic cough, weight loss, recurrent pneumonia, medical history including diabetes mellitus, hypertension, hyperlipidemia, as well past surgical colectomy hysterectomy (due to abnormal uterine bleeding normal...

Human immunodeficiency virus (HIV) transmission pattern in Iran has been changed from injection drug to sexual contact. Lack of accurate assessment HIV people with sexually transmitted diseases (STDs) prompted us conduct this study determine the frequency infection these patients.In cross-sectional which conducted 2016-2017, overall, 190 patients STDs referring two hospitals Hamadan were enrolled study. All examined for first visit by rapid test and then 1 4 months later 4th generation...

To highlight the graveness of invasive Aspergillus infections that could end in serious complications immunocompromised patients, we are going to report a rare case bilateral endophthalmitis lymphoma patient. We present an academic referring hospital. The patient was with diffuse large B-cell complicated vision loss due infection diagnosed B-mode ultrasound and culture followed by treatment vitrectomy intravitreous amphotericin. for 9 months, culminating visual acuity 4/100 1/100 her left...

Topic: 15. Myeloproliferative neoplasms - Biology & Translational Research Background: Polycythemia vera (PV) disease is an acquired and clonal stem cell disorder characterized by abnormal erythropoiesis. Identifying a unique mutation of increased activity in the Janus kinase 2 (JAK2) gene patients with chronic myeloproliferative disorders has provided beneficial diagnostic method. Aims: The present study evaluated exon 12 mutations JAK2 PV who had no V617F mutation. Methods: This...

در این مقاله به مطالعه تأثیر ارتباطات با وساطت رایانه تغییر ایستار بین فردی فرهنگی پرداخته شده است. 20 مصاحبه عمقی غیررسمی مجازی پاسخ دهندگانی غیر ایرانی ترتیب داده که حدود ده سال است کنندگان از طریق اینترنت آنها آشنایی دارند. ابتدا تلاش سازوکار تشکیل انگاره نسبت ایرانیان ذهن شوندگان غیرایرانی ارجاع مقوله بندی زبانی کارهای اربیب، کاکلین و هیل توصیف شود. همچنین برداشت های ای طبق الگوی وود چهار دسته سازه شخصی، سرنمونه ها، قالب واره ها نسخه تقسیم پایان نظریه سازگاری شناختی عاطفی روزنبرگ ابلسون...

Introduction: The effect of mothers' group discussion on the level knowledge and practice adolescent girls about puberty health in public high schools Ghaemieh 2019. Methods: present study was a quasi-experimental interventional with pre-test-post-test design control group. In this study, two were randomly selected 40 students from each school as sample. Group sessions mothers participated circular manner held during 4 for intervention once week minutes month. standard questionnaire Alizadeh...

Few cases of eosinophilia associated with B cell acute lymphoblastic leukemia (B-ALL) have been reported. This study reported a 16-year-old male patient diagnosed B-ALL and hypereosinophilia. He was admitted to the emergency department (ED) urticaria generalized itching. On initial examination, skin wholly erythematous, urticarial lesions were scattered throughout body. Peripheral blood smear (PBS) examined, eosinophils seen in different fields. However, blast cells not PBS. In bone marrow...

Extracting directional connectivity in a neuronal ensemble from spiking observations is key challenge understanding the circuit mechanisms of brain function. Existing methods proceed two stages, by first estimating latent processes that govern spiking, followed characterizing using said estimates. As such, extracted networks second stage are highly sensitive to accuracy estimates stage. In this work, we introduce framework directly extract Granger causal links observations, without requiring...