Background. Copper is an essential trace element found in the human body oxidized (Cu II) and reduced I) form. It plays a crucial role integrity function of proteins enzymes. Short-term long-term exposure to copper can result harmful effects lead clinical manifestations multiple bodily systems, including gastrointestinal tract, liver, kidneys, eyes, respiratory, cardiovascular, central nervous, endocrine, hematopoietic systems. Objective. The purpose this study importance early recognition...

Background and Objective. 5-Fluorouracil is one of the most common chemotherapeutic agents used in treatment solid tumors. 5-Fluorouracil-associated cardiotoxicity second cause induced by drugs after anthracyclines. Colchicine a strong anti-inflammatory drug to prevent treat acute gout familial Mediterranean fever. And also, its protective effects on cardiovascular disease have been reported various studies. The current study aimed at appraising effect colchicine 5-fluorouracil-induced rats....

Fluorouracil (5-FU) is the third most common chemotherapeutic agent used in treatment of solid tumors. 5-FU-associated cardiotoxicity ranks second causes induced by drugs after anthracyclines. Kaempferol (KPF), a flavonoid, possessing anti-inflammatory, antiapoptotic, antioxidative properties, and its protective effects on cardiovascular disease has been reported various studies. The current study aimed at appraising effect KPF nanoparticles (NPs) 5-FU-induced rats.Thirty Male Wistar rats...

Abstract 5-Fluorouracil (5-FU) is one of the most common chemotherapeutic agents used in treating solid tumors, and 5-FU-induced cardiotoxicity second cause induced by drugs. Propolis (Pro) has vigorous anti-inflammatory activity. Its cardio-protective characteristic against doxorubicin-induced was previously proven. The current study aimed to appraise effect Pro on rats. Twenty-four male Wistar rats were divided into four groups: Control, 5-FU, 5-FU + 250 mg/kg, Colchicine (CLC) 5 mg/kg....

Acute myeloblastic leukemia (AML) is the most common type of acute in adults. Despite numerous treatment strategies including chemotherapy and radiotherapy, a large number patients do not respond to experience relapse. The main problem these development resistance anti-cancer drugs. Therefore, any endeavor reduce drug high priority. In general, several mechanisms such as changes metabolic pathways, inactivation, target alterations reduced accumulation cells contribute cancer cells. this...

Iron is a necessary biological element and one of the richest in human body, but it can cause changes cell function activity control. involved wide range oxidation - reduction activities. Whenever iron exceeds cellular metabolic needs, its excess causes products respiration, such as superoxide, hydrogen peroxide hydroxyl. The formation these compounds toxicity. Lack control over reactive oxygen species damages to DNA, proteins, lipids. Conversely, hydroxyl are species, using antioxidants,...

Crystals of malachite green (MG), being water-soluble, are effective agents applied to combat fungal and parasitic infections in fish. This study was conducted evaluate the adsorption MG as a cationic dye by polymeric resin Amberlyst 15. Changes several parameters were observed, including concentration MG, pH, rate extent, temperature that might all affect efficiency adsorption. The method described well both Redlich-Peterson Langmuir isotherms with

Background Capecitabine (CAPE), an antimetabolite chemotherapy, can induce hepatic and renal toxicity. Melatonin (MEL), a neurohormone, possesses antioxidant, anti-apoptotic anti-inflammatory effects. This study investigated the impact of MEL on capecitabine-induced Methods materials Twenty-five male Wistar rats were categorized into five groups for study. The included control group, MEL10 group (rats receiving daily intraperitoneal injections 5 mg/kg MEL), CAPE 500 weekly CAPE), + 10 group....

Abstract 5‐Fluorouracil (5‐FU), which is one of the most widely used chemotherapy drugs, has various side effects on heart. Thymoquinone (TMQ), main bioactive component Nigella sativa , antioxidant and protective against toxicity. In this study, we investigated effect thymoquinone cardiotoxicity caused by 5‐FU in vitro vivo models. H9C2 cells were exposed to TMQ, cell viability was evaluated their presence. Also, 25 male Wistar rats divided into five control groups, 5‐FU, 2.5, 5 mg TMQ...

5-fluorouracil (5-FU) is a widely used chemotherapeutic agent, and its uncontrolled blood levels contribute to toxicity. Quercetin, as an important flavonoid, has many biological effects, including anti-tumor anti-inflammatory features. The current study investigated the synergistic effect between 5-FU quercetin using HT-29 cell line fibroblast cells. Rats were assigned two groups. 5-FU/quercetin group received intraperitoneal (10 mg/kg) Tween was injected control for 14 consecutive days. On...

Bisphenol A (BPA) and Nonylphenol (NP) have estrogen-like activity, some of their adverse biological effects been demonstrated. This study was designed to determine the association plasma tissue concentrations BPA NP changes in parameters reproductive system rats.Male Wistar rats were administered three doses (5, 25, 125 μg/kg) by gavage for 35 consecutive days 2014-2015, a 2-ml blood sample taken from each treated rat. Concentrations determined using HPLC-fluorescence detection method. The...

5-Fluorouracil (5FUra) is the third most popular chemotherapeutic component employed to treat solid tumors. In present study, we aimed appraise silymarin (SM) and nanoemulsion (SMN) effect on 5FUra-induced gastrointestinal toxicity in adult male rats. A total of 30 Wistar rats were divided into 6 groups including control (Crl) group, treated with SMN (5 mg.kg-1), SM 5FUra + mg.kg-1) by IP injection for 14 days. And was induced a single intraperitoneal (IP) (100 last group study. Treating...

Abstract Nephrotoxicity and hepatotoxicity include increased oxidative stress apoptosis; as a result, liver kidney damage are related to its pathogenesis. These significant side effects caused in cancer patients treated with 5‐FU. In the research, 25 rats were divided into five groups, including control, 5‐FU + 2.5, 5 10 mg/kg melatonin (MEL), protective impact of MEL against 5‐FU‐induced hepatorenal was investigated. harm, resulting severe renal failure histopathological changes. It also...

5-Fluorouracil (5-FU)-associated cardiotoxicity has been ranked as the second most common cause of induced by chemotherapeutic drugs after anthracyclines. In present study, we investigated protective impacts silymarin (SIL) and nanoemulsion (SLN) against caused 5-FU in rats. Thirty male Wistar rats were divided into six groups follows: control, SLN (5 mg/kg), SIL + SLN, SIL, 5-FU. Cardiotoxicity was a single intraperitoneal injection (100 mg/kg). The control group received an (ip) normal...

Thymoquinone (TQ) is one of the components extracted from Nigella sativa seeds and has antioxidant, anti-inflammatory, anticancer effects. We evaluated effect TQ on 5-fluorouracil (5-FU) pharmacokinetics (PK) in vivo vitro human colorectal cancer cell line. Ten Adult male Wistar rats were assigned to two groups. treated group received intraperitoneal once daily for 14 consecutive days (5 mg/kg). Both groups 5-FU (50 mg/kg) day 15 blood samples collected retro-orbital plexus. The parameters...

Background and Objective. Nonylphenol (NP), as an environmental pollutant, has adverse effects on the reproductive nervous systems through disrupting endocrine system inducing oxidative stress. This study was aimed at investigating protective effect of melatonin (MLT) NP-induced behavioral disorders in first-generation adult male rats. Methods. Pregnant Wistar rats were randomly assigned into five groups: control, NP (25 mg/kg), mg/kg)+MLT (10 (20 MLT mg/kg). The duration treatment 21 days...

One of the main causes acute liver failure is overdose with acetaminophen. Excessive consumption acetaminophen leads to production NAPQI (N-acetyl-p-benzoquinone imine) through activity enzyme cytochrome c oxidase. For this purpose, effect galangin nanoparticles antioxidant activities will be evaluated for treatment acetaminophen-induced hepatotoxicity. In study, after synthesis and particle size determination, mice were divided into six groups. Before treatment, a single dose (350 mg/kg)...

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Treatment of locally advanced rectal cancer (LARC) involves neoadjuvant chemoradiotherapy (nCRT), followed by total mesorectal excision. Examining the response to treatment is one most important factors in follow-up patients; therefore, this study, radiomics patterns derived from pretreatment computed tomography images and its relationship with measurement criteria have been investigated.