A5102934468- Pregnancy and preeclampsia studies
- Glaucoma and retinal disorders
- Gynecological conditions and treatments
- Intraocular Surgery and Lenses
- Corneal surgery and disorders
- Gestational Diabetes Research and Management
- Metabolism, Diabetes, and Cancer
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Birth, Development, and Health
- Ferroptosis and cancer prognosis
- Endometriosis Research and Treatment
- Ocular Disorders and Treatments
- Cardiovascular Issues in Pregnancy
- Reproductive System and Pregnancy
- Cancer, Lipids, and Metabolism
- Ophthalmology and Visual Impairment Studies
- Uterine Myomas and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Hernia repair and management
- Retinal Diseases and Treatments
- Diabetes Treatment and Management
- Long-Term Effects of COVID-19
- Extracellular vesicles in disease
- Maternal and fetal healthcare
- Corneal Surgery and Treatments
Chinese University of Hong Kong
2024-2025
Wuhan Red Cross Hospital
2020-2021
Ruijin Hospital
2020
Fujian University of Traditional Chinese Medicine
2019
Massachusetts General Hospital
2019
Harvard University
2019
The First People's Hospital of Zhaoqing
2004-2014
Beijing University of Chinese Medicine
2013
West China Medical Center of Sichuan University
2012
Iron (Fe) and copper (Cu), essential transition metals, play pivotal roles in various cellular processes critical to cancer biology, including cell proliferation, mitochondrial respiration, distant metastases, oxidative stress. The emergence of ferroptosis cuproptosis as distinct forms non-apoptotic death has heightened their significance, particularly connection with these metal ions. While initially studied separately, recent evidence underscores the interdependence cuproptosis. Studies...
Although type 2 diabetes mellitus (T2DM) has been reported as a risk factor for coronavirus disease 2019 (COVID-19), the effect of pharmacologic agents used to treat T2DM, such metformin, on COVID-19 outcomes remains unclear. Metformin increases expression angiotensin converting enzyme 2, known receptor severe acute respiratory syndrome 2. Data from people with T2DM hospitalized were test hypothesis that metformin use is associated improved survival in this population.Retrospective analyses...
Introduction: Ovarian cancer, characterized by its heterogeneity and resistance to conventional therapies such as cisplatin (CDDP), presents a significant clinical challenge. To address these challenges, we combined genome-scale CRISPR/Cas9 knockout screening, single-cell-CRISPR Purterb RNA sequencing (scRNA-seq), AI-driven virtual screening identify novel chemoresistance mechanisms evaluate potential therapeutic strategies. This integrated approach aims reveal genetic determinants...
Abstract Aims Type 2 diabetes mellitus (T2DM) is a strong risk factor for complications of coronavirus disease 2019 (COVID‐19). The effect T2DM medications on COVID‐19 outcomes remains unclear. In retrospective analysis cohort 131 patients with hospitalized in Wuhan, we have previously found that metformin use prior to hospitalization associated reduced mortality. current study aims investigate the effects inpatient medications, including metformin, acarbose, insulin and sulfonylureas,...
Introduction Pre-eclampsia (PE) affects about 5% of Chinese pregnant women and is a major cause maternal perinatal morbidity mortality. The first trimester screening model developed by the Fetal Medicine Foundation, which uses Bayes theorem to combine characteristics medical history together with measurements biomarkers, has been proven be effective superior performance that traditional risk factor-based approach for prediction PE. Prophylactic use low-dose aspirin in at PE resulted lower...
Abstract Preeclampsia (PE), a multisystem disorder in pregnancy, is one of the leading causes perinatal morbidity and mortality that poses financial physical burdens worldwide. Preterm PE with delivery at <37 weeks gestation associated higher risk adverse maternal outcomes than term ≥37 gestation. A myriad first trimester screening models have been developed to identifying women preterm PE. In fact, Fetal Medicine Foundation (FMF) prediction model has undergone successful internal...
The coronavirus disease 2019 (COVID-19) has been declared a global pandemic and is major public health issue worldwide. COVID-19 systemic damaging multiple organs, including the lung as main target organ. Approximately 14% patients develop severe 5% require admission to ICU. Those critically ill are often in state of stress, pain, anxiety due pathophysiology acute stage disease, underlying illness, psychological factors, environmental factors. increases organ function load, resulting...
Objective To study the biologic characteristics of patients with primary angle-closure glaucoma (PACG).Methods Biologic structure,including anterior chamber depth,lens thickness,length vitreous and axial length,were measured in 66 eyes acute PACG,31 chronic PACG 81 normal controls by A-mode ultrasonic scanning.The diameter cornea corneal curvature was also measured.All mean values were analyzed.Results There significant differences between all items.Acute had shallowest chamber,had shortest...
Objective To evaluate the efficacy of small incision and manual nuclear chopping combined with extracapsular cataract extraction intraocular lens implantation. Methoda 650 patients (725 eyes) who had undergone extracapsu- lar implantation were observed. During surgery, nucleus was separated by water via incisions lifted infusion loop, then chopped an irisrepositor; extracted implanted . The situation, postoperative visual acuity complications Results corrected acuity=0.5 in 630 eyes (86.90%)...