A5097355575- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- IL-33, ST2, and ILC Pathways
- Cytokine Signaling Pathways and Interactions
- Extracellular vesicles in disease
- MicroRNA in disease regulation
Ludwig-Maximilians-Universität München
2024-2025
Conventional dendritic cells (cDCs) are potent antigen-presenting (APCs) that integrate signals from their environment allowing them to direct situation-adapted immunity. Thereby they harbor great potential for being targeted in vaccination, autoimmunity, and cancer. Here, we use fate mapping, functional analyses, comparative cross-species transcriptomics show RORγt + DCs a conserved, functionally versatile, transcriptionally distinct type of DCs. entail various populations described...
Abstract Conventional dendritic cells (cDCs) are potent antigen presenting (APCs) that exhibit tissue and age-specific diversity allowing them to direct situation-adapted immunity. Thereby they harbor great potential for being targeted in vaccination cancer. Here, we resolve conflicting data about expression of retinoic acid receptor-related orphan receptor-γt (RORψt) cDCs. We show RORψt + DCs exist murine lymphoid non-lymphoid tissues across age. Fate mapping, functional assays single cell...