A5071327001- Immune Cell Function and Interaction
- Gut microbiota and health
- Infant Nutrition and Health
- Immune Response and Inflammation
- Antimicrobial Resistance in Staphylococcus
- Immunotherapy and Immune Responses
- Cervical Cancer and HPV Research
- IL-33, ST2, and ILC Pathways
- Nanoparticles: synthesis and applications
- Cancer Research and Treatments
- T-cell and B-cell Immunology
- Antibiotics Pharmacokinetics and Efficacy
- Salmonella and Campylobacter epidemiology
- Genetics, Aging, and Longevity in Model Organisms
- Neonatal Respiratory Health Research
- Global Cancer Incidence and Screening
- Endometrial and Cervical Cancer Treatments
- Vitamin C and Antioxidants Research
- Immune responses and vaccinations
- Antifungal resistance and susceptibility
RWTH Aachen University
2022-2025
Universitätsklinikum Aachen
2023-2024
Kiel University
2019-2022
Conventional dendritic cells (cDCs) are potent antigen-presenting (APCs) that integrate signals from their environment allowing them to direct situation-adapted immunity. Thereby they harbor great potential for being targeted in vaccination, autoimmunity, and cancer. Here, we use fate mapping, functional analyses, comparative cross-species transcriptomics show RORγt + DCs a conserved, functionally versatile, transcriptionally distinct type of DCs. entail various populations described...
Caenorhabditis elegans is associated in nature with a species-rich, distinct microbiota, which was characterized only recently [1Dirksen P. Marsh S.A. Braker I. Heitland N. Wagner S. Nakad R. Mader Petersen C. Kowallik V. Rosenstiel et al.The native microbiome of the nematode elegans: gateway to new host-microbiome model.BMC Biol. 2016; 14: 38Crossref PubMed Scopus (207) Google Scholar]. Thus, our understanding relevance microbiota for fitness still at its infancy. One major benefit that...
Early-life immune development is critical to long-term host health. However, the mechanisms that determine pace of postnatal maturation are not fully resolved. Here, we analyzed mononuclear phagocytes (MNPs) in small intestinal Peyer's patches (PPs), primary inductive site immunity. Conventional type 1 and 2 dendritic cells (cDC1 cDC2) RORgt+ antigen-presenting (RORgt+ APC) exhibited significant age-dependent changes subset composition, tissue distribution, reduced cell maturation,...
<i>Staphylococcus aureus</i> is an important pathogen causing various infections, including – as most frequently isolated bacterium cutaneous infections. Keratinocytes the first barrier cells of skin respond to <i>S. by release defense molecules such cytokines and antimicrobial peptides. Although several pattern recognition receptors expressed in keratinocytes Toll-like NOD-like have been reported detect presence aureus</i>, mechanisms underlying interplay between are...
Abstract Conventional dendritic cells (cDCs) are potent antigen presenting (APCs) that exhibit tissue and age-specific diversity allowing them to direct situation-adapted immunity. Thereby they harbor great potential for being targeted in vaccination cancer. Here, we resolve conflicting data about expression of retinoic acid receptor-related orphan receptor-γt (RORψt) cDCs. We show RORψt + DCs exist murine lymphoid non-lymphoid tissues across age. Fate mapping, functional assays single cell...
Purpose: Post-treatment follow-up in women with cervical pre-cancers (CIN3) is mandatory due to relapse up 10% of patients. Standard based on hrHPV-DNA/cytology co-testing has high sensitivity but limited specificity. The aim our prospective, multicenter, observational study was test the hypothesis that an individualized viral-cellular-junction (vcj-PCR) combined cytology a lower false positive rate for prediction recurrence compared standard co-testing. Methods: Pre-surgical swabs served...
Abstract Salmonella enterica subsp. serovar Typhimurium ( S. Typhimurium) translocates effector molecules via its pathogenicity island (SPI)1 encoded type 3 secretion system (T3SS) to induce internalization by intestinal epithelial cells and manipulate cellular responses. Among these molecules, the outer protein B (SopB) was shown possess phosphatidyl-inositol phosphatase activity bacterial internalisation, promote cell survival, influence endosomal trafficking alter host signalling. Using a...
Abstract Staphylococcus ( S .) aureus is an important pathogen causing various infections including - as most frequently isolated bacterium cutaneous infections. Keratinocytes the first barrier cells of skin respond to S. by release defense molecules such cytokines and antimicrobial peptides. Although several pattern recognition receptors expressed in keratinocytes Toll-like NOD-like have been reported detect presence , mechanisms underlying interplay between are still emerging. Here we...
Abstract Marked differences exist between the mucosal immune system of neonate and adult host. The pronounced influence enteric microbiota in adults suggests a causal relationship postnatal colonization maturation. However, using metagenomic, metaproteomic, functional immunological analyses we demonstrate an early presence bacteria immunogenic microbial antigens preceding maturation small intestine, primary inductive site intestinal immunity. Instead, transcriptomic, flow cytometric...