A5019026170- Immunotherapy and Immune Responses
- Bioinformatics and Genomic Networks
- T-cell and B-cell Immunology
- CRISPR and Genetic Engineering
- Mitochondrial Function and Pathology
- interferon and immune responses
- Computational Drug Discovery Methods
- Immune cells in cancer
- IL-33, ST2, and ILC Pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Cell Function and Interaction
- Nerve injury and regeneration
- Cell Adhesion Molecules Research
- Multiple Sclerosis Research Studies
- Immune Response and Inflammation
- RNA regulation and disease
- Spinal Cord Injury Research
- Gene Regulatory Network Analysis
- Neurogenesis and neuroplasticity mechanisms
- Autophagy in Disease and Therapy
Institute of Neuroimmunology of the Slovak Academy of Sciences
2022-2025
Ludwig-Maximilians-Universität München
2018-2025
Munich Cluster for Systems Neurology
2025
LMU Klinikum
2023
Urologische Klinik München
2023
German Cancer Research Center
2017
Heidelberg University
2017
Broad Institute
2017
Conventional dendritic cells (cDCs) are potent antigen-presenting (APCs) that integrate signals from their environment allowing them to direct situation-adapted immunity. Thereby they harbor great potential for being targeted in vaccination, autoimmunity, and cancer. Here, we use fate mapping, functional analyses, comparative cross-species transcriptomics show RORγt + DCs a conserved, functionally versatile, transcriptionally distinct type of DCs. entail various populations described...
Abstract Multiple sclerosis (MS) involves the infiltration of autoreactive T cells into CNS, yet we lack a comprehensive understanding signaling pathways that regulate this process. Here, conducted genome-wide in vivo CRISPR screen rat MS model and identified 5 essential brakes 18 facilitators cell migration to CNS. While transcription factor ETS1 limits entry CNS by controlling responsiveness, three functional modules, centered around adhesion molecule α4-integrin, chemokine receptor CXCR3...
Inflammation in the central nervous system can impair function of neuronal mitochondria and contributes to axon degeneration common neuroinflammatory disease multiple sclerosis (MS). Here we combine cell-type-specific mitochondrial proteomics with vivo biosensor imaging dissect how inflammation alters molecular composition functional capacity mitochondria. We show that lesions mouse spinal cord cause widespread persisting axonal ATP deficiency, which precedes oxidation calcium overload. This...
SUMMARY Multiple sclerosis (MS) is a neuroinflammatory disease initiated by the infiltration of autoreactive T cells into central nervous system (CNS). Several molecules that modulate cell CNS in MS have been identified, but how components adhesion, migration and signalling pathways interact to execute this fundamental step pathogenesis unknown. We conducted genome-wide vivo CRISPR screen an experimental autoimmune encephalomyelitis model identified 18 essential facilitators include known...
ABSTRACT Inflammation in the central nervous system (CNS) can impair function of neuronal mitochondria and contributes to axon degeneration common neuroinflammatory disease multiple sclerosis (MS). Here we combine cell type-specific mitochondrial proteomics with vivo biosensor imaging dissect how inflammation alters molecular composition functional capacity mitochondria. We show that lesions mouse spinal cord cause widespread persisting axonal ATP deficiency, which precedes oxidation calcium...