A5030465928- Advanced Glycation End Products research
- Musculoskeletal pain and rehabilitation
- Protein Kinase Regulation and GTPase Signaling
- Chronic Kidney Disease and Diabetes
- HIV Research and Treatment
- Attention Deficit Hyperactivity Disorder
- Cytomegalovirus and herpesvirus research
- Atherosclerosis and Cardiovascular Diseases
- Cholesterol and Lipid Metabolism
- Myofascial pain diagnosis and treatment
- Pain Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Monoclonal and Polyclonal Antibodies Research
- Immune Cell Function and Interaction
- Signaling Pathways in Disease
- Cancer-related Molecular Pathways
- Transcranial Magnetic Stimulation Studies
- Advanced biosensing and bioanalysis techniques
- Virology and Viral Diseases
- HIV/AIDS drug development and treatment
- Protein Degradation and Inhibitors
- Adipokines, Inflammation, and Metabolic Diseases
- Herpesvirus Infections and Treatments
- Bacteriophages and microbial interactions
- Pain Management and Treatment
Kumamoto University
2004-2024
The pathological significance of advanced glycation end product (AGE)-modified proteins deposited in several lesions is generally accounted for by their cellular interaction via the AGE receptors and subsequent acceleration inflammatory process. In this study, we focused on two receptors-specifically, role SR-A pathogenesis diabetic nephropathy CD36 AGE-induced downregulation leptin adipocytes. terms SR-A, wild-type mice exhibited increased urinary albumin excretion, glomerular hypertrophy,...
Inducing neutralizing antibodies (NAb) is the key to developing a protective vaccine against human immunodeficiency virus type 1 (HIV-1). To clarify neutralization mechanism of simian (SIV), we analyzed NAb B404, which showed potent and broad activity various SIV strains. In 4 SIVsmH635FC-infected macaques, B404-like using specific VH3 gene with long complementarity-determining region 3 loop λ light chain were major NAbs in terms number potency. This biased induction was observed all...
The humoral immune response is a mechanism that potently suppresses or prevents viral infections. However, genetic diversity and resistance to antibody-mediated neutralization are serious obstacles in controlling HIV-1 infection. In this study, we isolated monoclonal antibodies from an SIV-infected macaque by using the phage display method characterize SIV Variable regions of immunoglobulin genes were amplified rhesus macaque-specific primers inserted into phagemid pComb3X, which produced...
Abstract Neuromodulation through magnetic fields irradiation with ait® (AT-04), a device that irradiates mixed alternating (2 kHz and 83.3 MHz), has been shown to have high efficacy for fibromyalgia low back pain in our previous clinical trials. The aim of this study was elucidate the underlying analgesic mechanism AT-04 using partial sciatic nerve ligation (PSL) model as an animal neuropathic pain. applied PSL rats hyperalgesia its pain-improving effect verified by examining mechanical...
Journal Article Association of Advanced Glycation End Products with A549 Cells, a Human Pulmonary Epithelial Cell Line, Is Mediated by Receptor Distinct from the Scavenger Family and RAGE Get access Nahoko Nakano, Nakano *To whom correspondence should be addressed. Phone: +81-96-373-5071, Fax: +81-96-364-6940, E-mail: nagai@kaiju.medic.kumamoto-u.ac.jp Search for other works this author on: Oxford Academic PubMed Google Scholar Kaori Fukuhara-Takaki, Fukuhara-Takaki Tadashi Jono, Jono...
The role of antibodies in protecting the host from human immunodeficiency virus type 1 (HIV-1) infection is considerable interest, particularly because RV144 trial results suggest that contribute to protection. Although non-human primates with simian (SIV) commonly used as an animal model HIV-1 infection, viral epitopes elicit potent and broad neutralizing SIV have not been identified. We isolated a monoclonal antibody (MAb) B404 potently broadly neutralizes various strains. targets...
Abstract From a biochemical viewpoint, the cell cycle is controlled by phosphorylation of cyclin‐dependent kinase (CDK) substrates, and level determined enzymatic balance between CDK protein phosphatase 2A (PP2A). However, conventional techniques for analyzing using radioisotopes antibodies involve many operational steps take days before obtaining results, making them difficult to apply high‐throughput screening real‐time observations. In this study, we developed luminescent probes with...
Abstract Fibromyalgia is a common chronic pain disorder characterized by widespread and tenderness in mostly tendon attachments with unknown etiology. Treatment of fibromyalgia mainly drug other treatments, especially cognitive behavioral therapy exercise combined. However, drugs for have, general, broad adverse effects. Thus, an unmet medical need remains effective therapeutic modalities fibromyalgia. We have recently developed new magnetic device (project code “AT”) that has alternating...