A5085165220- Cardiac Valve Diseases and Treatments
- Phonocardiography and Auscultation Techniques
- Cardiac Arrhythmias and Treatments
- Metabolomics and Mass Spectrometry Studies
- Aortic Disease and Treatment Approaches
Kuopio University Hospital
2021-2023
Systolic murmur suggestive of aortic valve origin is a common accidental finding, particularly in the elderly. Usually, it due to stenosis (AS) or sclerosis (ASc). Currently, echocardiography used differentiate AS from ASc. Plasma N-terminal (NT)-prohormone BNP (NT-proBNP) known correlate with severity AS. We assessed whether NT-proBNP separates ASc.The study population consisted three groups: (n = 87, age 77 ± 7 years), ASc 76, 72 10 and healthy controls 101, 55 years). All subjects...
Abstract Background Calcific aortic valve disease (CAVD) is the most common valvular heart in Western world. CAVD ranging from mild sclerosis to severe obstructive stenosis (AS). The development of AS has been associated with several risk factors including age, sex and hypertension. However, there limited knowledge about that predict stenosis. Purpose We investigated if circulating metabolite profile can Finnish males. Methods did a non-targeted LC-MS metabolomics analysis baseline...