A5033176955- Tuberculosis Research and Epidemiology
- Pneumonia and Respiratory Infections
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Biomedical Text Mining and Ontologies
- Diagnosis and treatment of tuberculosis
- Genetics, Bioinformatics, and Biomedical Research
- Clostridium difficile and Clostridium perfringens research
- SARS-CoV-2 and COVID-19 Research
University of California, San Francisco
2023-2024
San Francisco General Hospital
2024
California Department of Public Health
2021-2023
Loma Linda University
2021
Orange County Healthcare Agency
2021
BackgroundNon-sputum-based triage tests for tuberculosis are a priority ending tuberculosis. We aimed to evaluate the diagnostic accuracy of late-prototype Xpert MTB Host Response (Xpert HR) blood-based assay.MethodsWe conducted prospective study among outpatients with presumed in outpatient clinics Viet Nam, India, Philippines, Uganda, and South Africa. Eligible participants were aged 18 years or older reported cough lasting at least 2 weeks. excluded those receiving treatment preceding 12...
Sputum-based testing is a barrier to increasing access molecular diagnostics for tuberculosis (TB). Many people with TB are unable produce sputum, and sputum processing increases assay complexity cost. Tongue swabs emerging as an alternative but performance limits uncertain.
Abstract Community health centers (CHC) play a key role in latent tuberculosis infection (LTBI) testing and treatment. We performed retrospective analysis of LTBI treatment among pediatric adult patients at CHC with large non-U.S.-born (USB) population during series quality improvement (QI) interventions from 2010 to 2019. Among 124,695 primary care visits, 40% were tested for (TB) those tested, 20% positive, including 39% adults aged 50–79 years. Compared 18–49 years, children 6–17 had...
C-reactive protein (CRP)-based tuberculosis (TB) screening is recommended for people with HIV (PWH). However, its performance among without and in diverse settings unknown.
Reliance on sputum-based testing is a key barrier to increasing access molecular diagnostics for tuberculosis (TB). Many people with TB are unable produce and sputum processing increases the complexity cost of assays. Tongue swabs emerging as an alternative sputum, but performance limits uncertain.
Background: Rapid diagnosis of tuberculosis (TB) is important for improving outcomes and reducing transmission. Previous studies assessing the impact Xpert MTB/RIF (Xpert), a molecular assay that provides results within two hours, on mortality have been inconclusive.Methods: In this planned analysis pragmatic cluster-randomized trial in Uganda, we assessed whether multicomponent strategy including decentralized testing decreased among adults evaluated TB. Ten community health centers were...
Rationale: C-reactive protein (CRP)-based tuberculosis (TB) screening is recommended for people with HIV (PWH). However, its performance among without and in diverse settings unknown. Objectives: In a multi-country study, we aimed to determine whether CRP meets the minimum accuracy targets (sensitivity ≥90%, specificity ≥70%) an effective TB test. Methods/Measurements: Consecutive outpatient adults cough ≥2 weeks from five endemic countries Africa Asia had baseline blood collected...
A key strategy to eliminate tuberculosis (TB) in the United States is increase latent infection (LTBI) screening, testing, and treatment among non-US-born Asian populations.The purpose was LTBI at a community clinic.Retrospective baseline data were retrieved through electronic medical record review. Interventions included adoption of standardized TB risk assessment, training providers use shorter regimens, care coordinator. Chart abstraction examine outcomes conducted postintervention 4...