A5062396330- Melanoma and MAPK Pathways
- Organ Transplantation Techniques and Outcomes
- Synthesis and biological activity
- Colorectal Cancer Treatments and Studies
- Renal Transplantation Outcomes and Treatments
- Liver physiology and pathology
- Liver Disease and Transplantation
- Organ Donation and Transplantation
- Cancer Mechanisms and Therapy
- Metabolism and Genetic Disorders
- Liver Disease Diagnosis and Treatment
- T-cell and B-cell Immunology
- Global Health Workforce Issues
- Global Health and Surgery
- Grief, Bereavement, and Mental Health
- Pancreatic function and diabetes
- Xenotransplantation and immune response
- Appendicitis Diagnosis and Management
- Diversity and Career in Medicine
- Dental Education, Practice, Research
- Neurological Complications and Syndromes
- Virus-based gene therapy research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Diverticular Disease and Complications
- Transplantation: Methods and Outcomes
Pfizer (United States)
2024
University of Cape Town
2008-2019
Groote Schuur Hospital
1999-2019
South African Medical Research Council
1980-2004
Austin Hospital
2000
University of Pittsburgh
1988-1993
Burlington College
1992
United States Department of Veterans Affairs
1990
RAF inhibitors have transformed treatment for patients with BRAFV600-mutant cancers, but clinical benefit is limited by adaptive induction of ERK signaling, genetic alterations that induce BRAFV600 dimerization, and poor brain penetration. Next-generation pan-RAF dimer are a narrow therapeutic index. PF-07799933 (ARRY-440) brain-penetrant, selective, pan-mutant BRAF inhibitor. inhibited signaling in vitro, disrupted endogenous mutant-BRAF:wild-type-CRAF dimers, spared wild-type signaling. ±...
Study design and data collectionThis study involved a descriptive analysis of surgical resources included the total number hospitals, hospital beds, general surgeons (specialist non-specialist), functional operating theatres in public private hospitals South Africa.The all district, regional tertiary nine provinces.
In this study the ability of normal liver to tolerate normothermic ischaemia was assessed. The survival rate in pigs after 3, 6 and 12 h hepatic 71, 46 0%, respectively. A patient who survived inadvertently being subjected 90 min is also presented. These findings suggest that 'safe period' for blood flow occlusion could be extended beyond 1 h.
Background: Human resources are the backbone of health-care delivery systems and lack surgical workforce in developing countries is often greatest challenge to providing care.The availability composition an important indicator strength health system.This study aimed analyse distribution general surgeons within South Africa.Methods: A descriptive analysis Africa was performed.The total number specialist non-specialist working public sector documented between periods from 1 October 2014 until...
<b><i>Background:</i></b> After renal transplantation, early graft function (EGF) can be divided into delayed (DGF), slow (SGF) and immediate (IGF). DGF is well documented. However, when evaluating the long-term significance of function, literature shows conflicting definitions inconsistent results. In addition, SGF, a new entity separate to IGF, recent poorly understood development. <b><i>Aim:</i></b> To investigate risk factors for impact...
Mesenchymal-epithelial transition factor (MET) is a receptor tyrosine kinase that serves critical function in numerous developmental, morphogenic, and proliferative signaling pathways. If dysregulated, MET has been shown to be involved the development survival of several cancers, including non-small cell lung cancer (NSCLC), renal cancer, other epithelial tumors. Currently, clinical efficacy FDA approved inhibitors limited by on-target acquired resistance, dose-limiting toxicities, less than...
The purpose of this study was to determine the incidence thoracic sepsis following a systematic cavity washout through injured diaphragm in patients with penetrating thoracoabdominal trauma.Prospectively collected data on all presenting trauma between July 1999 and 2002 were analysed. Patients peritoneal biliary-gastroenteric (BGE) contamination diaphragmatic laceration managed by laparotomy transdiaphragmatic lavage.A total 217 had injuries, whom 110 BGE spillage into pleural cavity. mean...
A technique of 65% partial hepatectomy in the pig is described. Thymidine kinase activity and mitotic index were used as indices liver regeneration. increased from a baseline value 1526 ± 256 to maximum 23992 4966 dpm/mg protein on third day after hepatectomy. The also 0–13.3 1.66 postoperative day. regeneration remained unchanged sham operation