A5024896583- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Porphyrin and Phthalocyanine Chemistry
- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Metal-Catalyzed Oxygenation Mechanisms
- Lanthanide and Transition Metal Complexes
- Supramolecular Chemistry and Complexes
- Synthesis and Catalytic Reactions
- Radioactive element chemistry and processing
- Magnetism in coordination complexes
- Radical Photochemical Reactions
- Photodynamic Therapy Research Studies
- Alzheimer's disease research and treatments
- Analytical Chemistry and Sensors
- Crystallography and molecular interactions
- Nanoplatforms for cancer theranostics
- Surface Chemistry and Catalysis
- Supramolecular Self-Assembly in Materials
- Photochemistry and Electron Transfer Studies
- Chemical synthesis and alkaloids
- Electrochemical Analysis and Applications
- Synthesis and Characterization of Pyrroles
- Antibiotic Resistance in Bacteria
- Oxidative Organic Chemistry Reactions
The University of Texas at Austin
2016-2025
Pfizer (United States)
2022-2025
Shanghai University
2018
Search for Extraterrestrial Intelligence
2015
An exoplanet extracted from the bright Direct imaging of Jupiter-like exoplanets around young stars provides a glimpse into how our solar system formed. The brightness requires use next-generation devices such as Gemini Planet Imager (GPI). Using GPI, Macintosh et al. discovered planet orbiting star, 51 Eridani (see Perspective by Mawet). planet, Eri b, has methane signature and is probably smallest that been directly imaged. These findings open door to understanding origins herald dawn new...
The hemispherand-strapped calix[4]pyrrole (1) acts as an ion pair receptor that exhibits selectivity for lithium salts. In organic media (CD2Cl2 and CD3OD, v/v, 9:1), 1 binds LiCl with high preference relative to NaCl, KCl, RbCl. DFT calculations provided support the observed selectivity. Single crystal structures of five different ion-pair complexes were obtained. case LiCl, a single bridging water molecule between cation chloride anion was observed, while tight contact pairs in LiBr, LiI,...
Alkyl azetidines have been prepared by photochemical modifications of azetidine-2-carboxylic acids in batch and flow. The reaction has realized mg-, g-, even multigram quantities. obtained are valuable building blocks for drug discovery.
Herein, we report a protein-based hybridization strategy that exploits the host–guest chemistry of HSA (human serum albumin) to solubilize otherwise cell impermeable ONOO<sup>−</sup> fluorescent probe <bold>Pinkment-OAc</bold>.
Deferasirox, ExJade, is an FDA-approved iron chelator used for the treatment of overload. In this work, we report several fluorescent deferasirox derivatives that display unique photophysical properties, i.e., aggregation-induced emission (AIE), excited state intramolecular proton transfer, charge and through-bond through-space conjugation characteristics in aqueous media. Functionalization phenol units on scaffold afforded responsive pro-chelator ExPhos, which enabled detection...
An expanded rosarian (P3P6) with a bowl-like conformation has been prepared and characterized in one-pot procedure that involves condensing bispyrrole pyridine precursor (P1P2) benzaldehyde, followed by oxidation. Single crystal X-ray diffraction analysis reveals the solid state an upper rim diameter defined meso-phenyl substituents of ca. 13.5 Å depth roughly 6.3 Å. P3P6 forms both 1:1 2:1 complexes C60 state. DFT similar energies for two binding modes. A stoichiometry dominates...
Here we report the first series of in-plane thorium(IV), uranium(IV), and neptunium(IV) expanded porphyrin complexes. These actinide (An) complexes were synthesized using a hexa-aza analogue, termed dipyriamethyrin, nonaqueous An(IV) precursors, ThCl4(DME)2, UCl4, NpCl4(DME)2. The molecular electronic structures ligand, each complex, corresponding uranyl(VI) complex characterized nuclear magnetic resonance (NMR) UV-vis spectroscopies as well single-crystal X-ray diffraction analysis....
An inherently nonlinear pyridine dipyrrolate ligand, namely 2,6-bis(3,4-diethyl-5-carboxy-1H-pyrrol-2yl)pyridine (compound 1), is able to distinguish between different zinc(II) cation sources, Zn(acac)2 and Zn(OAc)2, respectively. This differentiation manifest both in terms of the observed fluorescent behavior mixed organic media reaction chemistry. Treatment 1 with gives rise a cage dimer, cage-1, wherein two molecules compound act as double bridging units connect individual subunits. As...
Phenol-containing drugs may exhibit limited oral bioavailability due to first-pass conjugation in the intestine and liver, potentially unfavorable biopharmaceutical properties imparted by hydrogen-bond donor. We present a novel prodrug strategy which O-methylpyrimidine modification masks phenolic moiety employs aldehyde oxidase (AO) release parent drug. Prototypical prodrugs of 4-hydroxy-tamoxifen (4OH-TAM), raloxifene (RAL), rotigotine, 5-hydroxy-tolterodine, phentolamine were all...
Real-time visualization and tracking of epileptic seizures are important for studying epilepsy pathogenesis treating epilepsy; however, the requisite sensing is extremely challenging, primarily due to transient intricate nature neural activity associated with epilepsy. The onset closely correlated increases in peroxynitrite (ONOO-) levels, a reactive nitrogen species that can serve as biomarker However, fleeting biological half-life high reactivity ONOO- has historically impeded its direct...
Alkyl azetidines have been prepared by photochemical modifications of azetidine-2-carboxylic acids in batch and flow. The reaction has realized milligram, gram, even multigram quantities. obtained are valuable building blocks for drug discovery.
Porphyrin and related pyrrole-containing macrocycles, collectively porphyrinoids, are versatile ligands that allow access to a multitude of coordination modes. Judicious modification the porphyrin core as well pendant substituents has extended chemistry porphyrinoids include systems able stabilize f-block element complexes with possible utility. This review focuses on our group's efforts prepare expanded porphyrinogen can serve tools study apply f-element metal chemistry: it covers...
The reaction between non-aqueous uranyl silylamide (UO2[N(SiMe3)2]2·2THF) under anaerobic conditions or acetate (UO2(OAc)2·2H2O) standard laboratory and dipyriamethryin affords a bench-stable complex. Competition studies as well DFT calculations provide support for the observed selectivity cation over trivalent lanthanide multiple transition metal precursors.
The complex etiology of neurodegeneration continues to stifle efforts develop effective therapeutics. New agents elucidating key pathways causing might serve increase our understanding and potentially lead improved treatments. Here, we demonstrate that a water-soluble manganese(II) texaphyrin (MMn) is suitable magnetic resonance imaging (MRI) contrast agent for detecting larger amyloid beta constructs. potential MMn was inferred on the basis
A new set of PVA hydrogels were formed using the boronate ester fluorescent probe PF1 and novel PT1 as covalent crosslinkers. Treatment with aqueous H2O2 allowed triggered release dye accompanied by complete dissolution hydrogel.
Here, we report a new pentafluoropropanamido rhodamine fluorescent probe (ACS-HNE) that allows for the selective detection of neutrophil elastase (NE). ACS-HNE displayed high sensitivity, with low limit (<5.3 nM), and excellent selectivity toward over other relevant biological analytes enzymes. The comparatively poor solubility cell permeability neat was improved by creating an ACS-HNE-albumin complex; this approach allowed improvements in situ visualization activity RAW 264.7 cells relative...
A new mixed hexaphyrin, pyrihexaphyrin (0.1.0.0.1.0) (1), was prepared via an acid catalyzed cyclization between 5,5'-(pyridine-2,6-diyl)bis(pyrrole-2-carbaldehyde) (2) and terpyrrole (3). This expanded porphyrin undergoes a ring contraction upon metallation with uranyl silylamide [UO2[N(SiMe3)2]2] under anaerobic conditions followed by purification over basic aluminum oxide exposed to air. The uranyl-contracted (0.0.0.0.1.0) complex (4) produced as result contains unique structural...
Photoredox-transition metal dual catalysis provides a unique platform for constructing sp3-rich chemical matter. Here, we report nickel-catalyzed cross-coupling of commercially available or easily prepared redox-active NHP azetidine-2-carboxylates with heteroaryl iodides to yield 2-heteroaryl azetidines. This "off-the-shelf" approach yielded products amenable diversification giving access novel saturated heterocyclic scaffolds useful medicinal chemistry programs. An alternative mechanism...
Mesenchymal-epithelial transition factor (MET) is a receptor tyrosine kinase that serves critical function in numerous developmental, morphogenic, and proliferative signaling pathways. If dysregulated, MET has been shown to be involved the development survival of several cancers, including non-small cell lung cancer (NSCLC), renal cancer, other epithelial tumors. Currently, clinical efficacy FDA approved inhibitors limited by on-target acquired resistance, dose-limiting toxicities, less than...