A5056531820- Genetic Associations and Epidemiology
- Genetics and Neurodevelopmental Disorders
- Mental Health Research Topics
- Pain Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Birth, Development, and Health
- Functional Brain Connectivity Studies
- Heart Rate Variability and Autonomic Control
- Cognitive Abilities and Testing
- Epigenetics and DNA Methylation
- Cardiovascular Health and Risk Factors
- Cardiac Health and Mental Health
- Health, Environment, Cognitive Aging
- Attention Deficit Hyperactivity Disorder
- Musculoskeletal pain and rehabilitation
- Resilience and Mental Health
- Neurotransmitter Receptor Influence on Behavior
- School Health and Nursing Education
- Sleep and related disorders
- Cardiomyopathy and Myosin Studies
- Dementia and Cognitive Impairment Research
- Metabolism and Genetic Disorders
- Metabolomics and Mass Spectrometry Studies
- Circadian rhythm and melatonin
- Bioinformatics and Genomic Networks
Yale University
2023-2025
VA Connecticut Healthcare System
2023-2025
Connecticut Health Foundation
2023-2024
Aristotle University of Thessaloniki
2022
We characterized the genetic architecture of attention-deficit hyperactivity disorder-substance use disorder (ADHD-SUD) relationship by investigating correlation, causality, pleiotropy, and common polygenic risk. Summary statistics from genome-wide association studies (GWAS) were used to investigate ADHD (Neff=51,568), cannabis (CanUD, Neff=161,053), opioid (OUD, Neff=57,120), problematic alcohol (PAU, Neff=502,272), tobacco (PTU, Neff=97,836). ADHD, CanUD, OUD GWAS meta-analyses included...
ABSTRACT We leveraged information from more than 1.2 million participants to investigate the genetics of anxiety disorders across five continental ancestral groups. Ancestry-specific and cross-ancestry genome-wide association studies identified 51 anxiety-associated loci, 39 which are novel. Additionally, polygenic risk scores derived individuals European descent were associated with in African, Admixed-American, East Asian The heritability was enriched for genes expressed limbic system,...
ABSTRACT Psychiatric disorders and symptoms are associated with differences in pain perception sensitivity. These can have important implications treating spinal degenerative disease (SDD) chronic low-back (CLBP). Leveraging data from the UK Biobank (UKB) All of Us Research Program (AoU), we investigated effects linking psychiatric (alcohol use disorder, anxiety, attention deficit hyperactivity bipolar cannabis depression, opioid posttraumatic stress schizophrenia) to SDD CLBP. We applied...
The development of posttraumatic stress disorder (PTSD) is attributable to the interplay between exposure severe traumatic events, environmental factors, and biological characteristics. Blood brain imaging markers have been associated with PTSD. However, our knowledge, no study has systematically investigated genetic relationship PTSD, metabolic biomarkers, brainwide imaging. We integrated genome-wide data informative 233 3935 imaging-derived phenotypes (IDPs). Pleiotropy was assessed by...
ABSTRACT INTRODUCTION While higher socioeconomic factors (SEF) and cognitive performance (CP) have been associated with reduced Alzheimer’s disease (AD) risk, recent evidence highlighted that these may opposite effects on family history of AD (FHAD). METHODS Leveraging data from the UK Biobank (N=448,100) All Us Research Program (N=240,319), we applied generalized linear regression models, polygenic risk scoring (PRS), one-sample Mendelian randomization (MR) to test sex-specific SEF CP...
Patients with post-traumatic stress disorder (PTSD) experience higher risk of adverse cardiovascular (CV) outcomes. This study explores shared loci, and genes between PTSD CV conditions from three major domains: diagnoses electronic health records (CV-EHR), cardiac aortic imaging, behaviors defined in Life's Essential 8 (LE8).
Evening chronotypes (a.k.a. night-owls) are held to be at greater risk for psychiatric disorders. This is postulated due delayed circadian timing increasing the likelihood of misalignment in an early-oriented society. Circadian known heighten sleep inertia, difficulty transitioning from wake characterized by low arousal and cognitive impairment, evening experience inertia. Therefore, awakening may explain relationship between chronotype disorders acting as a biomarker misalignment. In...
Anxiety disorders are associated with decreased heart rate variability (HRV), but the underlying mechanisms remain elusive.We selected individuals whole-genome sequencing, Fitbit, and electronic health record data (N=920; 61,333 points) from All of Us Research Program. PRS were derived PRS-CS after meta-analyzing anxiety genome-wide association studies three major cohorts-UK Biobank, FinnGen, Million Veterans Program (N Total =364,550). The standard deviation average RR intervals (SDANN) was...
To gain insights into the role of brain structure and function on anxiety (ANX), we conducted a genetically informed investigation leveraging information from ANX genome-wide association studies available UK Biobank (UKB; N=380,379), FinnGen Program (N=290,361), Million Veteran (MVP; N=199,611) together with UKB data (N=33,224) related to 3,935 imaging-derived phenotypes (IDP).A genetic correlation analysis between IDPs was performed using linkage disequilibrium score regression. investigate...
What distinguishes vulnerability and resilience to posttraumatic stress disorder (PTSD) remains unclear. Levering traumatic experiences reporting, genetic data, electronic health records (EHR), we investigated predicted the clinical comorbidities (co-phenome) of PTSD in UK Biobank (UKB) All Us Research Program (AoU), respectively. In 60,354 trauma-exposed UKB participants, defined considering symptoms, trauma burden, polygenic risk scores. EHR-based phenome-wide association studies (PheWAS)...
ABSTRACT Objective This study investigated the genetic and epigenetic mechanisms underlying comorbidity patterns of five substance dependence diagnoses (SDs; alcohol, AD; cannabis, CaD; cocaine, CoD; opioid, OD; tobacco, TD). Methods A latent class analysis (LCA) was performed on 31,197 individuals (average age 42±11 years; 49% females) from six cohorts to identify comorbid DSM-IV SD patterns. In subsets this sample, we tested SD-latent classes with respect polygenic burden psychiatric...