A5101595982- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Asymmetric Synthesis and Catalysis
- Fluorine in Organic Chemistry
- Synthesis and Catalytic Reactions
- Catalytic C–H Functionalization Methods
- Cyclopropane Reaction Mechanisms
- Synthesis of Indole Derivatives
- Crystallography and molecular interactions
- Axial and Atropisomeric Chirality Synthesis
- Catalytic Alkyne Reactions
- Asymmetric Hydrogenation and Catalysis
- Chemical synthesis and alkaloids
- Metal-Organic Frameworks: Synthesis and Applications
- Oxidative Organic Chemistry Reactions
- Covalent Organic Framework Applications
- Carbohydrate Chemistry and Synthesis
- Catalytic Cross-Coupling Reactions
- Dendrimers and Hyperbranched Polymers
Sun Yat-sen University
2020-2024
Guangdong Pharmaceutical University
2024
Guangxi University of Chinese Medicine
2016-2020
Guangxi University
2017-2020
Nanning Normal University
2016-2018
Herein, we report an enantioselective dehydrative γ-arylation of α-indolyl propargylic alcohols with phenols via organocatalysis, which provides efficient access to chiral tetrasubstituted allenes and naphthopyrans in high yields excellent regio- enantioselectivities under mild conditions. This method features the use cheaply available naphthols/phenols as C–H aryl source liberating water sole byproduct. Control experiments suggest that enantioselectivity remote regioselectivity stem from...
A highly general and straightforward approach to access chiral bis(indolyl)methanes (BIMs) bearing quaternary stereocenters has been realized
A chiral phosphoric acid-catalyzed asymmetric bis-cyclization of α-indolyl propargylic alcohols with 2-indolylmethanols was realized.
A catalytic asymmetric umpolung cross-Mannich reaction of cyclic ketimines is realized. This protocol provides an efficient methodology for the facile synthesis chiral vicinal tetrasubstituted diamines in high yields with excellent chemo-, regio-, diastereo-, and enantioselectivities using cinchona-derived bifunctional organocatalysts (85-98% yield, up to >20:1 dr, >99% ee).
A series of 3′-trifluoromethyl substituted 3,2′-pyrrolidinyl-bispirooxindoles were constructed<italic>via</italic>an asymmetric Michael/cyclization cascade reaction.
Under bifunctional squaramide and thiourea organocatalysis, a series of vicinally bis(trifluoromethyl)-substituted 3,3′-pyrrolidinyl spirooxindoles were successfully synthesized via 1,3-dipolar cycloaddition reactions 3-(trifluoroethylidene)oxindoles with diethyl 2-((2,2,2-trifluoroethyl)imino)malonate N-(2,2,2-trifluoroethyl)isatin ketimines. The highlight this protocol is the efficient construction pyrrolidine unit spirooxindoles, including multiple contiguous stereogenic centres, in...
A porous MOF with [Cu<sub>2</sub>(COO)<sub>4</sub>] SBU was constructed from tricarboxylic acid ligand and pyrazine, which features a unique hendecahedron cage-liked cavity good stability high BET surface, showing controlled drug release properties of ibuprofen over anethole guaiacol.
A series of CF<sub>3</sub>-containing oxazolidines were constructed<italic>via</italic>organocatalytic asymmetric oxa-1,3-dipolar cycloaddition. These could undergo facile conversion to 1,2-amino alcohols with vicinal stereogenic centers.
α-Arylated ketones were accessed <italic>via</italic> oxyallyl cation capture with arylboronic acids in good yields broad substrate tolerance.