Obesity is a global disease that causes many metabolic disorders. However, effective agents for the prevention or treatment of obesity remain limited. This study investigated anti-obesity effect and mechanism chitosan oligosaccharide capsules (COSCs) on rats suffering from induced by high-fat diet (HFD). After eight-week administration COSCs obese rats, body weight gain, fat/body ratio, related biochemical indices were measured. The hepatic expressions leptin signal pathway (JAK2-STAT3) gene...

Chitooligosaccharide is beneficial for inhibiting dyslipidemia and reducing atherosclerotic hyperlipidemic risk. The purpose of this study was to investigate the cholesterol-regulating effects potential mechanisms tablets (CFTs) in high-fat diet-induced rats. results revealed that CFTs can regulate serum lipid levels rats a dosage-dependent manner. Synchronously, gene expressions related cholesterol excretion were upregulated manner, including 7α-hydroxylase (CYP7A1), liver X receptor α...

A highly general and straightforward approach to access chiral bis(indolyl)methanes (BIMs) bearing quaternary stereocenters has been realized

A chiral phosphoric acid-catalyzed asymmetric bis-cyclization of α-indolyl propargylic alcohols with 2-indolylmethanols was realized.

Chitosan oligosaccharides can alleviate liver endoplasmic reticulum stress to improve lipid metabolism and reduce obesity caused by high-fat diet.

Soybean mosaic virus (SMV), which belongs to the Potyviridae, causes significant reductions in soybean yield and seed quality. In this study, both tag-free reporter gene green fluorescent protein (GFP)-containing infectious clones for SMV N1 strain were constructed by Gibson assembly with yeast homologous recombination system, respectively. Both are suitable agroinfiltration on model host N. benthamiana show strong infectivity natural several other legume species. transmitted caused typical...

Diabetes mellitus (DM) and thyroid dysfunction (TD) are two closely associated disorders. The objective of the present study was to investigate status relationships between hormones, diabetic complications metabolic parameters in hospitalized patients with newly diagnosed type 2 DM (T2DM). This an observational cross-sectional study, conducting on 340 T2DM who were admitted ward endocrinology department 120 matched individuals without diabetes. Anthropometric, clinical biochemical data...

Chitosan oligosaccharides, with an average molecular weight ≤ 1000 Da (COST), is a natural marine product that has the potential to improve intestinal microflora and resist lipid metabolism disorders.First, by establishing mice model of disorder induced high fat sugar diet, it proven COST can reduce disorder, which may play role in regulating microorganisms. Then, key treatment microorganisms further confirmed through method COST-treated feces fecal bacteria transplantation.intestinal...

Whether cortisol secretion is linked with microalbuminuria remains undefined.We aimed to investigate the relationship between serum levels and presence of in patients type 2 diabetes (T2DM) prediabetes.A cross-sectional study was conducted 211 T2DM or prediabetes.Serum measured at 8:00 h, 16:00 0:00 h.The level circadian rhythm ACTH were also evaluated.Urine excretion albumin measured.Patients subdivided into (MAU) group (n= 120) normoalbuminuria (NAU) (n = 91) according status...

Mitochondrial dysfunction-induced apoptosis plays a crucial role in the progression of diabetic cardiomyopathy (DCM). Sestrin2 is an important oxidative stress response protein and involved maintenance mitochondrial function, especially under stress. The aim present study was to investigate DCM explore underlying mechanisms. H9c2 cardiomyocytes were induced with high glucose (HG) medium (33 mmol/l glucose) for vitro model. C57BL/6 mice vivo model by intraperitoneal streptozotocin injection....

Purpose . Liver fibrosis is the hallmark of chronic nonalcoholic steatohepatitis (NASH) and characterised by excessive deposition extracellular matrix proteins. Early detection accurate staging liver critically important for patient management. One earliest pathological markers in NASH activation hepatic stellate cells (HSCs) which may be exploited as a marker fibrogenesis. Activated HSCs secreting factors such integrin α v β 3 propagate fibrosis. The purpose current study was to assess...

The incidence of thyroid nodules is increasing year by around the world. However, ultrasound not recommended as a screening test for general population or patients with normal on palpation American Association Clinical Endocrinologists (AACE). In practice, some individuals have that can just be found out ultrasound. No studies directly described risk up to now. More evidence needed carry helping us balance over diagnosis and missed malignant lesions. Therefore, we carried retrospective study...

Abstract Healthcare providers treating newborns with asymmetric cry syndrome should consider 22q11.2 microdeletion within the differential diagnosis list and order appropriate genetic testing.

The goal was to explore the value of using radiomics analysis based on multimodal MRI for evaluating advanced fibrosis in patients with hepatitis B.One hundred and forty-three B were randomly divided into training validation cohorts a 2:1 ratio. In cohort, clinical model established logistic regression, signature support vector machine (SVM), nomogram integrated factors. three models assessed by ROC cohorts.The demonstrated largest area under curve. presented good agreement prediction...

The target molecule is a cathepsin S inhibitor and lead for the treatment of immunological disorders. synthesis depicted operationally simple, high-yielding, chromatography-free. Because its high molecular weight (699 Da) polarity, purification was challenging.

Objective: To establish and evaluate chronic stress model in New Zealand white rabbit with hyperlipidemia. Methods: A total of 45 clearing grade male rabbits were divided into four groups random number table method: control (CON), normal diet combined for 8 weeks (CON+ CS), high fat (HFD) 4 (HFD+ CS). Both social physical methods adopted.One-way ANOVA was used comparison among groups. Results: (1) Chronic assessments: ①body weight, the weight gain significantly reduced; ②behavioral...

Objective To determine the spectrum of mutations responsible for Phenylalanine hydroxylase (PAH) deficiency on phenylketonuria (PKU) patients Han Chinese people in Huaihai region central China. Methods One hundred and one diagnosed with PKU were referred to Xuzhou Maternity Child Health Care Hospital genetic counseling/analysis from January 2003 December 2013.Thirteen exons PAH gene mutations, as well their flanking introns, identified 202 chromosomes using polymerase chain...

Abstract Background : Diabetes mellitus (DM) and thyroid dysfunction (TD) are two closely associated disorders. The coexistence of TD could adversely influence metabolic control even increase the long-term mortality in patients with DM. objective present study was to investigate prevalence risk factors type 2 DM (T2DM). Methods This is an observational cross-sectional study. A total 340 newly diagnosed T2DM who were admitted ward endocrinology department included for analysis. Thyroid...

Abstract Background : Diabetes mellitus (DM) and thyroid dysfunction (TD) are two closely associated disorders. The coexistence of TD could adversely influence metabolic control even increase the long-term mortality in patients with DM. objective present study was to investigate prevalence risk factors type 2 DM (T2DM). Methods This is an observational cross-sectional study. A total 340 newly diagnosed T2DM who were admitted ward endocrinology department included for analysis. Thyroid...

The case report describes a newborn of ACS based on clinical presentation(s) and microdeletions 22q11.21 11p15.4 using DNA high throughput sequencing analysis. This finding has implications for diagnosis overcomes the limitations associated with FISH by across whole genome.