Lisa Marie Milchsack
A5109821515- Inflammatory Bowel Disease
- Microscopic Colitis
- Cancer Immunotherapy and Biomarkers
- IL-33, ST2, and ILC Pathways
- Single-cell and spatial transcriptomics
Wellcome Sanger Institute
2024
Abstract The gastrointestinal tract is a multi-organ system crucial for efficient nutrient uptake and barrier immunity. Advances in genomics surge diseases 1,2 has fuelled efforts to catalogue cells constituting tissues health disease 3 . Here we present systematic integration of 25 single-cell RNA sequencing datasets spanning the entire healthy development adulthood. We uniformly processed 385 samples from 189 controls using newly developed automated quality control approach (scAutoQC),...
The gastrointestinal (GI) tract consists of connected organs, from the oral cavity to rectum, which function ensure efficient nutrient uptake and barrier immunity. Diseases GI affect millions worldwide as such there are now over 25 published single cell RNA-sequencing (scRNAseq) datasets surveying tract, profiling specific anatomical regions, lineages, ages diseases. To consolidate these efforts, we harmonised integrated scRNAseq across whole developing adult human tissues, well newly...