A5103258451- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Heart Failure Treatment and Management
- Pulmonary Hypertension Research and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiomyopathy and Myosin Studies
- Transplantation: Methods and Outcomes
- Cardiac and Coronary Surgery Techniques
- Tracheal and airway disorders
- Cardiac Valve Diseases and Treatments
- Congenital Diaphragmatic Hernia Studies
- Cardiac Ischemia and Reperfusion
- Metabolism and Genetic Disorders
- Respiratory Support and Mechanisms
- Insect Resistance and Genetics
- Entomopathogenic Microorganisms in Pest Control
- Cardiac pacing and defibrillation studies
- Viral Infections and Immunology Research
- Amino Acid Enzymes and Metabolism
- Insect-Plant Interactions and Control
- Child Nutrition and Water Access
- Hemodynamic Monitoring and Therapy
- Renal Transplantation Outcomes and Treatments
St Vincent's Hospital
2024
University of Kentucky
2023
Health Sciences Centre
2023
University of Manitoba
2023
INTEGRIS Baptist Medical Center
2013-2022
Oklahoma Blood Institute
2005-2018
Cincinnati Children's Hospital Medical Center
2004-2017
University of Cincinnati
2004-2017
Flinders University
2017
LDS Hospital
2012
Objectives: The purpose of this study was to determine the incidence renal insufficiency in children hospitalized with acute decompensated heart failure and whether worsening function is associated adverse cardiovascular outcome. Design: Prospective observational cohort study. Setting: Single-center children's hospital. Patients: All pediatric patients from birth age 21 yrs admitted our institution October 2003 2005. Interventions: None. Measurements Main Results: Acute defined as new-onset...
Background —Hemodynamic stability after Norwood palliation often requires manipulation of pulmonary vascular resistance to alter the pulmonary-to-systemic blood flow ratio (Q̇p:Q̇s). Q̇p:Q̇s is estimated from arterial saturation (Sa o 2 ), a practice based on untested assumptions: constant systemic arteriovenous O difference and normal venous saturation. Methods Results —In 12 patients early (≤3 days) palliation, simultaneous arterial, superior vena caval (Ssvc (Spv ) oximetry was used test...
To improve communication during daily cardiac ICU multidisciplinary rounds.Quality improvement methodology.Twenty-five-bed ICUs in an academic free-standing pediatric hospital.All patients admitted to the ICU.Implementation of visual display patient goals through a write-down and read-back process.The Rounds Effectiveness Assessment Communication Tool was developed based on previously validated Patient Knowledge evaluate comprehension goals. were assessed for each by bedside nurse, nurse...
Inhaled nitric oxide (iNO) is front-line therapy for pulmonary hypertension after repair of congenital heart disease. However, little clinical data exists regarding the effects iNO on regulators vascular resistance. An imbalance between primary vasodilators, such as NO, and vasoconstrictors, endothelin-1 (ET-1), has been implicated in rebound upon withdrawal. The objective this study was to determine whether alters plasma ET-1 levels.This a prospective involving pediatric adult patients at...
In many diseases, tissue hypoxia occurs in conjunction with other inflammatory processes. Since previous studies have demonstrated a role for leukocytes ischemia/reperfusion injury, we hypothesized that endothelial may "superinduce" expression of an important leukocyte adhesion molecule, E-selectin (ELAM-1, CD62E). Bovine aortic monolayers were exposed to the presence or absence tumor-necrosis factor alpha (TNF-alpha) lipopolysaccharide (LPS). Cell surface was quantitated by whole cell ELISA...
Abstract Vitamin A deficiency in rat small intestine caused a decrease the synthesis of fucose-containing glycopeptide (Fuc-glycopeptide) and reduction goblet cells. The cellular localization Fuc-glycopeptide was studied by indirect fluorescent antibody technique. purified as previously described. Its purity confirmed polyacrylamide gel electrophoresis agar immunodiffusion test. An antiserum to prepared chickens used localize Fucglycopeptide immunofluorescence present only
Mutations in cardiac motor protein genes are associated with familial hypertrophic cardiomyopathy. both the regulatory (Glu22Lys) and essential light chains (Met149Val) result an unusual pattern of hypertrophy, leading to obstruction midventricular cavity. When a human genomic fragment containing Met149Val myosin chain was used generate transgenic mice, phenotype recapitulated. To unambiguously establish causal relationship for mutations cardiomyopathy, we generated mice that expressed...
The B-subunit of the cholera toxin molecule (CT-B) has T-cell immunomodulatory properties. Because pathogenesis diabetes in nonobese diabetic (NOD) mouse model IDDM is thought to be a Tcell-mediated process due an imbalance immunoregulatory and anti-islet effector cells, we examined effect CT-B administration on development NOD assessed whether this potential diabetes-sparing mediated by changes and/or cytotoxic cell activity. either intravenous or intraperitoneal decreased with no apparent...
Objective. Success in treatment of premature infants has resulted increased numbers neonates who have bronchopulmonary dysplasia (BPD) and require surgical palliation or repair congenital heart disease (CHD). We sought to investigate the impact BPD on children with CHD after surgery. Methods. This was a retrospective, multicenter study patients had BPD, defined as being oxygen dependent at 28 days age radiographic changes, cardiac surgery (excluding arterial duct ligation) between January...
To name a sensibility, to draw its contours and recount history, requires deep sympathy modified by revulsion. Susan Sontag, "Notes on Camp" One evening in the late 1940s, Hannah Arendt Mary McCarthy found themselves standing together subway platform uncomfortable silence. Though both were returning home from an editorial meeting for magazine politics, which they had served some time, neither spoken other since their disastrous first encounter at party six years earlier. approached said her...