A5062200690- Molecular Junctions and Nanostructures
- Nanowire Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Nanopore and Nanochannel Transport Studies
- Advanced Fluorescence Microscopy Techniques
- Quantum and electron transport phenomena
- Mechanical and Optical Resonators
- Plasmonic and Surface Plasmon Research
- Photosynthetic Processes and Mechanisms
- Advanced MEMS and NEMS Technologies
- Graphene research and applications
- Protein Structure and Dynamics
- Force Microscopy Techniques and Applications
- Copper Interconnects and Reliability
- ATP Synthase and ATPases Research
- Advancements in Semiconductor Devices and Circuit Design
- DNA Repair Mechanisms
- Optical Coatings and Gratings
- Various Chemistry Research Topics
- Spectroscopy and Quantum Chemical Studies
- Advanced Electron Microscopy Techniques and Applications
- Surface and Thin Film Phenomena
- Semiconductor materials and devices
Peking University
1987-2024
Tokyo Institute of Technology
2024
University of Science and Technology Beijing
2021-2024
Beijing National Laboratory for Molecular Sciences
2021-2024
Intrinsically disordered proteins (IDPs) play crucial roles in cellular processes and hold promise as drug targets. However, the dynamic nature of IDPs remains poorly understood. Here, we construct a single-molecule electrical nanocircuit based on silicon nanowire field-effect transistors (SiNW-FETs) functionalize it with an individual c-Myc bHLH-LZ domain to enable label-free, situ, long-term measurements at level. We use device study interaction Max and/or small molecule inhibitors....
Ten negative differential resistances (NDRs) were demonstrated in the output characteristics of molecularly-anchored single PbS quantum dot resonant tunneling transistors, which utilized heteroepitaxial spherical Au/Pt nanogap electrodes.
Abstract The degradation process of RNA is decisive in guaranteeing high-fidelity translation genetic information living organisms. However, visualizing the single-base real time and deciphering mechanism at single-enzyme level remain formidable challenges. Here, we present a reliable in-situ single-PNPase-molecule dynamic electrical detector based on silicon nanowire field-effect transistors with ultra-high temporal resolution. These devices are capable realizing real-time label-free...
DNA-protein interaction plays an essential role in the storage, expression, and regulation of genetic information. A 1D/3D facilitated diffusion mechanism has been proposed to explain extraordinarily rapid rate DNA-binding protein (DBP) searching for cognate sequence along DNA further studied by single-molecule experiments. However, direct observation detailed chronological image is still a formidable challenge. Here, first time, electrical monitoring technique utilized realize label-free...
Abstract Single‐molecule junctions exploit the internal structure of molecular orbitals to construct a new class functional quantum devices. The demonstration negative differential resistance (NDR) in single‐molecule is direct evidence mechanical tunneling through orbital. Here, pronounced NDR effect reported with peak‐to‐valley ratio 30.1 on junction π‐conjugated quinoidal‐fused oligosilole derivatives, Si2 × 2, embedded between unique electroless gold‐plated heteroepitaxial spherical Au/Pt...
The function of proteins depends on their structural flexibility and conformational change. By utilizing silicon-nanowire-based single-molecule electrical circuits, here we present a label-free real-time measurement method that can directly monitor changes photosynthetic LH1-RC complex, reaching the ultimate goal analytic chemistry. These results manifest conformation complex vibrates among four conformations with strong temperature dependence. At optimal temperature, States 2 3 occupy main...
A mechano-sliding strategy for controllable assembly of nanowires was demonstrated by directly transferring chemical vapor deposition grown silicon to obtain nanoscale electronic devices.
By inserting methylene groups at the molecule edges, stable junctions are fabricated.
Intrinsically disordered proteins (IDPs) are emerging therapeutic targets for human diseases. However, probing their transient conformations remains challenging because of conformational heterogeneity. To address this problem, we developed a biosensor using point-functionalized silicon nanowire (SiNW) that allows real-time sampling single-molecule dynamics. A single IDP, N-terminal transactivation domain tumor suppressor protein p53 (p53
Abstract Photosynthesis is a very important process for the current biosphere which can maintain such subtle and stable circulatory ecosystem on earth through transformation of energy substance. Even though been widely studied in various aspects, physiological activities, as intrinsic structural vibration self‐regulation to stress photosynthetic proteins, are still not in‐depth resolved real‐time. Herein, utilizing silicon nanowire biosensors with ultrasensitive temporal spatial resolution,...
Single-Molecule Studies An unprecedented high-resolution single-molecule electrical detection platform offering a complete description of protein-DNA interactions is developed in article number 2101383 by Xiaodong Su, Xuefeng Guo, and co-workers. Detailed investigation real time shed light on the whole protein searching process with single-base resolution. By in-situ monitoring trajectories individual molecules, this unveils fundamental laws interactions, demonstrating infinite possibilities...