A5003787003- Bladder and Urothelial Cancer Treatments
- Epigenetics and DNA Methylation
- Fibroblast Growth Factor Research
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Liver physiology and pathology
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Psychedelics and Drug Studies
- Drug Transport and Resistance Mechanisms
- Lung Cancer Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Cancer Research and Treatments
- Agricultural pest management studies
- Sexuality, Behavior, and Technology
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Lipid metabolism and biosynthesis
- Pancreatitis Pathology and Treatment
- RNA Interference and Gene Delivery
- Genomics, phytochemicals, and oxidative stress
- Nutrition and Health in Aging
- Agricultural Practices and Plant Genetics
- Cholesterol and Lipid Metabolism
- Cancer Immunotherapy and Biomarkers
University of Padua
2021-2024
Abstract Aberrations of the fibroblast growth factor receptor (FGFR) family members are frequently observed in metastatic urothelial cancer (mUC), and blocking FGF/FGFR signaling axis is used as a targeted therapeutic strategy for treating patients. Erdafitinib pan-FGFR inhibitor, which has recently been approved by FDA mUC with FGFR2/3 alterations. Although patients show initial response to erdafitinib, acquired resistance rapidly develops. Here, we found that adipocyte precursors promoted...
Abstract Liposomes play an important role in the field of drug delivery by virtue their biocompatibility and versatility as carriers. Stealth liposomes, obtained surface decoration with hydrophilic polyethylene glycol (PEG) molecules, represent turning point liposome technology, leading to significant improvements pharmacokinetic profile compared naked liposomes. Nevertheless, generation effective targeted liposomes—a central issue for cancer therapy—has faced several difficulties clinical...
Nonalcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease, and no drugs have been approved for its therapy.Among plant-derived molecules, phenolic compounds extra virgin olive oil like tyrosol (Tyr) had demonstrated multiple beneficial actions health, including the modulation inflammation in fibrosis.This study aims at assessing protective effect mechanism Tyr vitro vivo models NASH, with focus on hepatic immune microenvironment extrahepatic manifestations.The was...
Liver fibrosis is the result of a chronic pathological condition caused by activation hepatic stellate cells (HSCs), which induces excessive deposition extracellular matrix. Fibrogenesis sustained an exaggerated production reactive oxidative species (ROS) NADPH oxidases (NOXs), are overactivated in inflammation. In this study, we investigated antifibrotic properties two phenolic compounds natural origin, tyrosol (Tyr) and hydroxytyrosol (HTyr), known for their antioxidant anti-inflammatory...
Recently, some preclinical and clinical studies have demonstrated the ability of brown seaweeds in reducing risk factors for metabolic syndrome. Here, we analyzed beneficial effect a nutraceutical formulation containing phytocomplex extracted from chromium picolinate animal models liver steatosis differing severities (rats with non-alcoholic fatty disease (NAFLD) its complication, steatohepatitis (NASH)). This treatment led to significant drop hepatic fat deposition both (p < 0.01 vs....
In this work, we conceived and developed antibody-drug conjugates (ADCs) that could efficiently release the drug after enzymatic cleavage of linker moiety by tumoral proteases. The linkers used are result a rational optimization previously reported PEGylated linker, PUREBRIGHT® MA-P12-PS, which showed excellent loading capacities but lacked an inbuilt discharge mechanism, thus limiting potency resulting ADCs. To address limitation, chose to incorporate protease-sensitive trigger into favor...
Liver fibrosis is a common and reversible feature of liver damage associated with many chronic diseases, its onset influenced by sex. In this study, we investigated the mechanisms regeneration, focusing on understanding mechanistic gaps between females males. We injected increasing doses carbon tetrachloride into female male mice maintained them for washout period eight weeks to allow regeneration. found that were more prone developing severe as consequence early damage, supported...
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<div>Abstract<p>Aberrations of the fibroblast growth factor receptor (FGFR) family members are frequently observed in metastatic urothelial cancer (mUC), and blocking FGF/FGFR signaling axis is used as a targeted therapeutic strategy for treating patients. Erdafitinib pan-FGFR inhibitor, which has recently been approved by FDA mUC with FGFR2/3 alterations. Although patients show initial response to erdafitinib, acquired resistance rapidly develops. Here, we found that adipocyte...
<div>Abstract<p>Aberrations of the fibroblast growth factor receptor (FGFR) family members are frequently observed in metastatic urothelial cancer (mUC), and blocking FGF/FGFR signaling axis is used as a targeted therapeutic strategy for treating patients. Erdafitinib pan-FGFR inhibitor, which has recently been approved by FDA mUC with FGFR2/3 alterations. Although patients show initial response to erdafitinib, acquired resistance rapidly develops. Here, we found that adipocyte...
<p>Supplementary Figure6</p>