A5020964806- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Photoacoustic and Ultrasonic Imaging
- Synthesis and Biological Evaluation
- Polymer Surface Interaction Studies
- Advanced Drug Delivery Systems
- Optical Imaging and Spectroscopy Techniques
- Advancements in Battery Materials
- Recycling and Waste Management Techniques
- Enzyme function and inhibition
- Hydrogels: synthesis, properties, applications
- Luminescence and Fluorescent Materials
- Advanced Battery Technologies Research
- Synthesis and Catalytic Reactions
- Advanced Polymer Synthesis and Characterization
- Click Chemistry and Applications
- Cholinesterase and Neurodegenerative Diseases
- Photopolymerization techniques and applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Extracellular vesicles in disease
- Phenothiazines and Benzothiazines Synthesis and Activities
- Cancer therapeutics and mechanisms
- Nanoparticle-Based Drug Delivery
- Advanced Chemical Sensor Technologies
Georgia State University
2020-2022
Lehman College
2014
City University of New York
2014
We have synthesized and characterized a library of near-infrared (NIR) heptamethine cyanine dyes for biomedical application as photoacoustic imaging photothermal agents. These hydrophobic were incorporated into polymer-based nanoparticle system to provide aqueous solubility protection the photophysical properties each dye scaffold. Among those analyzed, 13 compounds within nontoxic polymeric nanoparticles been selected exemplify structural relationships in terms photostability, imaging,...
Abstract Fluorescence‐guided surgery (FGS) aids surgeons with real‐time visualization of small cancer foci and borders, which improves surgical prognostic efficacy cancer. Despite the steady advances in imaging devices, there is a scarcity fluorophores available to achieve optimal FGS. Here, 1) pH‐sensitive near‐infrared fluorophore that exhibits rapid signal changes acidic tumor microenvironments (TME) caused by attenuation intramolecular quenching, 2) inherent targeting for based on...
Abstract Optoacoustic imaging is a new biomedical technology with clear benefits over traditional optical and ultrasound. While the has improved since its initial development, creation of dedicated contrast agents for optoacoustic been stagnant. Current exploration limited to standard commercial dyes that have already established in applications. some these compounds demonstrated utility imaging, they are far from optimal there need tailored properties. The synthesis, encapsulation within...
Optoacoustic imaging has grown in clinical relevance due to inherent advantages sensitivity, resolution, and depth, but the development of contrast agents is lacking. This study assesses influence structural features squaraine dyes on optoacoustic activity through computational models, vitro testing, vivo experimentation. The scaffold was decorated with halogens side-chain extensions. Extension side chains heavy halogenation squaraines both increased signals individually, although they had a...
A heptamethine fluorophore, ERB-60, has been synthesized efficiently in four steps a good yield. The structure of this fluorophore consists an electron-donating group (methoxy), hydrophobic moiety (phenylpropyl) with rotatable bond, quaternary ammonium fragment, and indolium rings at the terminal ends connected via polymethine chain. All these inherent chemical features fine-tuned optical properties fluorophore. This compound was characterized by both 1H NMR, 13C NMR mass spectra....
Thirteen red-shifted pentamethine dimethyl and diethylamino tetrahydroxanthylium derivatives have been successfully synthesized via the microwave-assisted approach. The optimized conditions developed in synthesis provided an excellent yield expedited reaction time. These newly dyes show well-defined optical properties resulting from diverse substitutions at central meso positions. majority of compounds a maximum wavelength absorbance within 946-1022 nm with extinction coefficients range...
Graphite anode has lower capacity, but silicon and lithium metal anodes have higher capacities yet safety concerns due to volume expansions. The expansion related issues occur during the charging discharging process throughout life of battery. objective is therefore present an alternative that will exhibit desirable properties. We employed a novel manufacturing technique involved new nanostructured material composition, mixing coating processes synthesize nanolayered binder free iron oxide...