A5054141506- Glycosylation and Glycoproteins Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Histone Deacetylase Inhibitors Research
- Transplantation: Methods and Outcomes
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Organ Transplantation Techniques and Outcomes
- Cancer, Lipids, and Metabolism
- Mitochondrial Function and Pathology
- Congenital Anomalies and Fetal Surgery
- Diet, Metabolism, and Disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Galectins and Cancer Biology
- Metabolism and Genetic Disorders
- Pancreatitis Pathology and Treatment
- Cancer-related molecular mechanisms research
- RNA regulation and disease
- RNA modifications and cancer
- Herpesvirus Infections and Treatments
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- Carbohydrate Chemistry and Synthesis
- interferon and immune responses
- Colorectal Cancer Treatments and Studies
- Cancer Mechanisms and Therapy
Drexel University
2023-2025
Pennsylvania State University
1983-2023
St James's University Hospital
2009-2012
Florida State University
1994
Valparaiso University
1994
Science and Technology Corporation (Norway)
1994
Campbell Scientific (Canada)
1994
Atmospheric and Environmental Research
1994
Plymouth State University
1994
Purdue University West Lafayette
1994
Breast cancer brain metastasis (BCBM) typically results in an end-stage diagnosis and is hindered by a lack of brain-penetrant drugs. Tumors the rely on conversion acetate to acetyl-CoA enzyme synthetase 2 (ACSS2), key regulator fatty acid synthesis protein acetylation. Here, we used computational pipeline identify novel ACSS2 inhibitors combining pharmacophore-based shape screen methodology with absorption, distribution, metabolism, excretion (ADME) property predictions. We identified...
The growth of breast tumors is driven and controlled by a subpopulation cancer cells resembling adult stem cells, which are called stem-like (CSCs). In cancer, the function maintenance CSCs influenced protein O-GlcNAcylation enzyme responsible for this post-translational modification, O-GlcNAc transferase (OGT). However, mechanism regulation OGT cycling in still unclear. Analysis proteome O-GlcNAcome, revealed GATAD2B, component Nucleosome Remodeling Deacetylase (NuRD) complex, as substrate...
Abstract Breast-cancer brain metastasis (BCBM) poses a significant clinical challenge, resulting in an end-stage diagnosis and hindered by limited therapeutic options. The blood-brain barrier (BBB) acts as anatomical physiological hurdle for compounds, restricting the effective delivery of therapies to brain. In order grow survive nutrient-poor environment, tumors must adapt their metabolic needs, becoming highly dependent on acetate. These rely conversion acetate acetyl-CoA enzyme...
ABSTRACT Brain metastasis diagnosis in breast cancer patients is considered an end-stage event. The median survival after measured months, thus there urgent need to develop novel treatment strategies. Breast cancers that metastasize the brain must adapt unique environment and are highly dependent on acetate metabolism for growth survival. However, signaling pathways regulate metastatic (BCBM) tumors not known. Primary tumor cells can convert acetyl-CoA via phosphorylation of synthetase 2...
<h3>Introduction</h3> Hepatocellular carcinoma (HCC) behaves differently in cirrhotic and non-cirrhotic livers. Microvascular invasion (MVI) is a key determinant of outcome following curative treatment for HCC. Despite attempts to reach consensus, reliably identifying microvascular remains difficult. Interrogating factors influencing MVI patients with or without cirrhosis may determine more identifiable surrogates provide valuable insight into the underlying biology <h3>Methods</h3> Review...
<h3>Introduction</h3> Non-anatomical resection (NAR) for colorectal liver metastasis (CRLM) has become more common in an attempt to preserve parenchyma. Pattern of recurrence (POR) following NAR been reported previously, but there no detail on the hepatic recurrences with respect previous NAR. We aim investigate pattern patients who underwent CRLM, especially looking at context resected segment. <h3>Methods</h3> 1580 CRLM were performed our centre between 1993 and 2010. 591 (37.4%) 989...
<h3>Introduction</h3> The impact of poor nutritional status on the outcome following liver transplantation in children is well recognised. Recently studies adults and have reported variable effects obesity post transplant morbidity mortality. This study examines pretransplant body mass index (BMI) current era consecutive from a single centre. <h3>Methods</h3> Data were retrieved prospectively maintained institutional database 1994 to 2009. Patients stratified into five BMI categories...
Introduction: The impact of poor nutritional status on the outcome following liver transplantation in children is well recognised. Recently studies adults and have reported variable effects obesity post transplant morbidity mortality. This study examines pretransplant body mass index (BMI) current era consecutive from a single centre. Methods: Data was retrieved prospectively maintained institutional database 1994-2009. Patients were stratified into 5 BMI categories established by WHO...
95 AMS/lndustry Undergraduate Scholarships.Eleven leading environmental science