A5050432203- Cancer Immunotherapy and Biomarkers
- Ferroptosis and cancer prognosis
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Immune cells in cancer
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Immunotherapy and Immune Responses
- Glutathione Transferases and Polymorphisms
- Medical Imaging and Pathology Studies
- Peptidase Inhibition and Analysis
- Single-cell and spatial transcriptomics
- Cancer therapeutics and mechanisms
- Circular RNAs in diseases
- Bladder and Urothelial Cancer Treatments
- Pancreatic and Hepatic Oncology Research
- Mathematical Biology Tumor Growth
- Congenital Diaphragmatic Hernia Studies
Hangzhou DAC Biotech (China)
2023
Despite significant benefits from targeted therapy in patients with driver mutations, inevitable drug resistance usually occurred non-small cell lung cancer, highlighting the necessity for sequential treatments to prolong overall survival. Unfortunately, durable response has not been reported posterior-line of cases acquired
The combination of PD-1 blockade with neoadjuvant chemotherapy (NAC) has achieved unprecedented clinical success in non-small cell lung cancer (NSCLC) compared to NAC alone, but the underlying mechanisms by which augments effects remain incompletely elucidated. Single-cell RNA sequencing was performed on CD45+ immune cells isolated from surgically resected fresh tumors seven NSCLC patients receiving or pembrolizumab and (NAPC). Multiplex fluorescent immunohistochemistry FFPE tissues before...
Introduction Tumor-infiltrating myeloid cells (TIMs) are key regulators in tumor progression, but the similarity and distinction of their fundamental properties pancreatic ductal adenocarcinoma (PDAC) remain elusive. Method In this study, we conducted scRNA-seq data analysis from 12 primary (PT) tissues, 4 metastatic (Met) 3 adjacent normal pancreas tissues (Para), PBMC samples across 16 PDAC patients, revealed a heterogeneous TIMs environment PDAC. Result Systematic comparisons between...
Abstract Background The increasing prevalence of multiple primarylung cancers (MPLCs) presents challenges to current diagnostic and clinicalmanagement approaches. However, the molecular mechanisms driving MPLCdevelopment distinguishing it from solitary primary lung (SPLCs)remain largely unexplored. Methods We performed a comparative single‐cell RNAsequencing (scRNA‐seq) analysis on tumour adjacent para‐tumour tissues fromMPLC SPLC patients comparatively evaluate their immunological...
Targeted therapy has significantly prolonged survival of non-small cell lung cancer (NSCLC) patients carrying common
e17589 Background: Aberrant metabolism is a major characteristic of cancer and it important to determine whether there common metabolic genetic signature among gynecological cancers. Endometrial cancer, as one the tumors, has shown increasing morbidity mortality rates annually. Investigating shared molecular markers in tumors can enhance our understanding endometrial cancer. Methods: Transcriptome data for including ovarian (OV), (UCEC) cervical (CESC) were obtained from The Cancer Genome...
e20063 Background: Regulatory T cells (Tregs) suppress immune responses and can promote tumor growth metastasis during cancer progression. Studies have shown that tumor-infiltrating Tregs upregulate inhibitory gene programs after checkpoint blockade therapy. Targeting is believed to be a valuable approach enhance the effectiveness of immunotherapy. However, precise role in microenvironment, their connection treatment resistance mechanisms, how changes activity impact are still not well...
e20064 Background: Currently, there is a relatively extensive research emphasis on tumor microenvironment based single-cell transcriptomics. However, the investigation of metabolic aspects rare due to technological limitations. To address this gap, our study employes scFEA and MEBOCOST, which are level prediction tools transcriptomics, explore landscape in lung adenocarcinoma(LUAD). Methods: This utilized four sequencing (scRNA-seq) datasets, two targeted metabolomics TCGA-LUAD RNA dataset...
e16261 Background: Tumor-infiltrating myeloid cells (TIMs) are abundant in tumor stroma and emerging evidence indicate that the presence of these influences clinical outcomes many cancer types. TIMs play important roles progression specific subsets may exhibit divergent anti-tumor or tumor-promoting functions. Currently, molecular characteristics pancreatic ductal adenocarcinoma (PDAC) largely remain unknown. Like other programmed cell death procedures such as ferroptosis pyroptosis,...
e16544 Background: Compared with single-cell RNA-sequencing (scRNA-seq), Single-nuclei RNA-sequencing(snRNA-seq) can detect more genes higher sensitivity, and it is robust in identifying cellular markers. TIGIT+ exhausted T cells were reported significantly associated poor prognosis muscle invasive bladder cancer(MIBC) by flow cytometry. We aimed to evaluate unique markers of MIBC via snRNA-seq construct a potential prognostic survival model. Methods: collected data from 25 4 non-MIBC...
e21002 Background: Immunotherapy, represented by immune checkpoint inhibitors (ICIs), has revolutionized the treatment strategies in multiple cancer types, including NSCLC. Anti-PD1 combined with chemotherapy was superior to alone, but fundamental mechanisms underlying their synergic effect remain incompletely understood. Here, we investigated different effects induced neoadjuvant pembrolizumab (NAPC) and (NAC) on tumor microenvironment patients Methods: We performed single-cell...
e20566 Background: Lung squamous cell carcinoma (LUSC) is one of the most common subtypes lung cancer which lacks effective treatments compared to adenocarcinoma. The Th1 subset in CD4 + T cells plays an indispensable role antitumor immune responses. However, there are few studies on LUSC. Methods: Firstly, we used single-cell RNA-seq analyze gene expression 8 LUSC patients’ tissues, including tumor paracancerous normal lymphoid pre-treatment blood samples and pre-operative samples. A total...
e20584 Background: The combination of immune checkpoint inhibitors (ICIs) with chemotherapy (chemoimmunotherapy) in the neoadjuvant setting have achieved favorable clinical benefits non-small cell lung cancer (NSCLC), but underlying molecular mechanism has not been fully elucidated. Methods: To identify factors associated outcome, single-cell RNA/TCR sequencing was performed using 10x Genomics on CD45 + cells isolated from tumor and multiple immune-relevant tissues peripheral blood four...
e16021 Background: Gastric Cancer (GC) is the third leading cause of cancer-related mortality around world, with a relatively poor prognosis. Single-cell RNA-sequencing (scRNA-seq) powerful tool to analyze tumor microenvironment at comprehensive resolution, revealing previously uncharacterized molecular complexities. CNVs detection based on scRNA-seq data can reveal genome heterogeneity, therefore identify prognostic biomarkers single cell level. Methods: ScRNA-seq from publicly available...