A5103028513- Advanced X-ray Imaging Techniques
- Ovarian cancer diagnosis and treatment
- Advanced Electron Microscopy Techniques and Applications
- Gyrotron and Vacuum Electronics Research
- Renal cell carcinoma treatment
- Particle Accelerators and Free-Electron Lasers
- Chromatin Remodeling and Cancer
- Microfluidic and Capillary Electrophoresis Applications
- X-ray Spectroscopy and Fluorescence Analysis
- Advanced Measurement and Metrology Techniques
- Electron and X-Ray Spectroscopy Techniques
- Terahertz technology and applications
- Optical Coherence Tomography Applications
- Microfluidic and Bio-sensing Technologies
- Particle accelerators and beam dynamics
- Renal Diseases and Glomerulopathies
- Radiation Effects and Dosimetry
- Optical Systems and Laser Technology
- Cancer Mechanisms and Therapy
- Advanced Optical Sensing Technologies
- Advanced X-ray and CT Imaging
- Near-Field Optical Microscopy
- Photoacoustic and Ultrasonic Imaging
- Advanced Fluorescence Microscopy Techniques
- Medical Imaging Techniques and Applications
National University Cancer Institute, Singapore
2024
National University Hospital
2020-2023
National Agency for New Technologies, Energy and Sustainable Economic Development
2001-2015
National University of Singapore
2010
Ovarian clear cell carcinoma (OCCC) is associated with chemoresistance. Limited data exists regarding the efficacy of targeted therapies such as immune checkpoint inhibitors (ICI) and bevacizumab, role secondary cytoreductive surgery (SCS).
An innovative route for deep-submicrometer spatial resolution hard x-ray microscopy with tabletop source is proposed. A film of lithium fluoride (LiF) was used as imaging detector in contact mode. We present here the images recorded on LiF films a Fresnel zone plate submicrometer gold structures and an onion cataphyll. The were read optical confocal microscope fluorescence measured about 250nm, i.e., close to limit microscope. advantages drawbacks, possible improvements, this are discussed.
In this paper, the use of lithium fluoride (LiF) as imaging radiation detector to analyse living cells by single-shot soft X-ray contact microscopy is presented. High resolved images on LiF cyanobacterium Leptolyngbya VRUC135, two unicellular microalgae genus Chlamydomonas and mouse macrophage (line RAW 264.7) have been obtained utilizing in water window energy range from a laser plasma source. The used method based loading samples, cell suspension, special holder where they are close with...
In this work, we report a method to observe soft X-ray radiographs at nanoscale of various kind samples, biological and metallic, stored in thin layer lithium fluoride, employing scanning near-field optical microscopy with an resolution that reaches 50 nm. Lithium fluoride material works as novel image detector for nano-radiographs, due the fact extreme ultraviolet radiation X-rays efficiently produce stable point defects emitting optically stimulated visible luminescence surface layer. The...
The development of both transmissive and reflective THz imaging is under way at ENEA-Frascati employing a compact free electron laser (THz GFEL). high peak power available makes the FEL particularly suitable for long range detection. Different setup was tested different levels spatial resolution to image objects from few centimetre square larger sizes.
At ENEA-Frascati THz imaging experiments have been set-up in the biological and environmental field utilizing a Compact Free Electron Laser (C-FEL) at 130 GHz [1], second source, FEL-CATS, operating range 0.4 to 0.7 [2].
A novel experimental setup for transmission x-ray microscopy is presented. It based on the use of a point isotropic x- ray source and single spherical crystal. The beam intensity modulated by object attenuation, then monochromatized enlarged using crystal and, lastly, imaged detector downstream We demonstrate tracing technique testing that this system allows studies with image resolution better than dimensions source, high magnification ratios, great field view. Microscopes model ca be...