A5034133196- T-cell and B-cell Immunology
- HIV Research and Treatment
- Immune Cell Function and Interaction
- Mosquito-borne diseases and control
- Studies on Chitinases and Chitosanases
- RNA regulation and disease
- melanin and skin pigmentation
- Italy: Economic History and Contemporary Issues
- Skin Protection and Aging
Conservatoire National des Arts et Métiers
2024-2025
HESAM Université
2025
Génomique Bioinformatique et Applications
2023
We have reanalyzed the genomic data from International Collaboration for Genomics of HIV (ICGH), focusing on HIV-1 Elite Controllers (EC). A genome-wide association study (GWAS) was performed, comparing 543 EC individuals with 3,272 uninfected controls (CTR) European ancestry. 8 million single nucleotide polymorphisms (SNPs) and HLA class I II gene alleles were imputed to compare CTR. Two thousand six hundred twenty-six SNPs associated (p<5.10-8), all located within Major Histocompatibility...
Aim: In 2005-2006, a chikungunya epidemic of unprecedented magnitude hit Reunion Island, which raised public health concern through the substantial proportions long-lasting manifestations. To understand pathophysiology underlying chronic (CC), we designed CHIKGene cohort study and collected blood samples from 133 subjects diagnosed with CC 86 control individuals that had recovered within 3 months, 12-to-15 years after exposure. Methods: We conducted bulk RNAseq analysis on peripheral...
Motivation: Haplotype blocks in the genome are informative of evolutionary processes and they play a pivotal role describing genomic variability across human populations susceptibility/resistance to diseases. Several software have been developed for haplotype detection, but do not distinguish between impacts major minor SNP alleles. In this study, we present powerful haploblock detection software, specifically designed identifying haploblocks associated with allele (MiA-haploblocks). These...
We have reanalyzed the genomic data of International Collaboration for Genomics HIV (ICGH), centering on HIV-1 Elite Controllers.
Skin aging is an ineluctable process leading to the progressive loss of tissue integrity and characterized by various outcomes such as wrinkling sagging. Researchers have identified impacting environmental factors (sun exposure, smoking, etc.) several molecular mechanisms skin aging. We previously performed genome-wide association studies (GWAS) in 502 very-well French women, looking for associations with four major aging, namely, photoaging, solar lentigines, wrinkling, sagging, this has...
Abstract Introduction We have reanalyzed the genomic data from International Collaboration for Genomics of HIV (ICGH), focusing on HIV-1 Elite Controllers (EC). Methods A genome-wide association study (GWAS) was performed, comparing 543 EC individuals with 3,272 uninfected controls (CTR) European ancestry. 8 million single nucleotide polymorphisms (SNPs) and HLA class I II gene alleles were imputed to compare CTR. Results 2,626 SNPs associated (p<5.10-8), all located within Major...