A5090771124- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Advanced Breast Cancer Therapies
- Pancreatic and Hepatic Oncology Research
- Chronic Lymphocytic Leukemia Research
- Breast Cancer Treatment Studies
- Chromatin Remodeling and Cancer
- Cancer-related Molecular Pathways
- Pleural and Pulmonary Diseases
- Cancer Treatment and Pharmacology
- Occupational and environmental lung diseases
- Abdominal Surgery and Complications
- Pneumothorax, Barotrauma, Emphysema
- Cancer therapeutics and mechanisms
- Lung Cancer Research Studies
- Pelvic and Acetabular Injuries
- Hernia repair and management
- Genetic factors in colorectal cancer
Sağlık Bilimleri Üniversitesi
2024
Ankara Onkoloji Eğitim ve Araştırma Hastanesi
2024
St. Josefs Hospital
2009-2023
St. Josef-Hospital
2009-2023
Pancreatic carcinoma lacks effective therapeutic strategies resulting in poor prognosis. Transcriptional dysregulation due to alterations KRAS and MYC affects initiation, development, survival of this tumor type. Using patient-derived xenografts KRAS- MYC-driven pancreatic carcinoma, we show that coinhibition topoisomerase 1 (TOP1) bromodomain-containing protein 4 (BRD4) synergistically induces regression by targeting promoter pause release. Comparing the nascent transcriptome with...
Abstract Background High-level evidence regarding the technique of abdominal wall closure for patients undergoing emergency midline laparotomy is sparse. Therefore, we conducted a randomized controlled trial (RCT) to evaluate efficacy and safety two commonly applied strategies after primary laparotomy. Methods/design CONTINT was multi-center pragmatic open-label exploratory parallel trial. Two different in an surgical intervention with suspected septic focus cavity were compared: continuous,...
The development of secondary resistance (SR) in metastatic colorectal cancer (mCRC) treated with anti-epidermal growth factor receptor (anti-EGFR) antibodies is not fully understood at the molecular level. Here we tested vivo selection anti-EGFR SR tumors CRC patient-derived xenograft (PDX) models as a strategy for dissection mechanisms. We analyzed 21 KRAS, NRAS, BRAF, and PI3K wildtype their sensitivity. Furthermore, 31 were generated via chronic treatment cetuximab. A multi-omics approach...
Background/Objectives: Dose reductions in CDK4/6 inhibitors, such as ribociclib and palbociclib, are often necessary due to treatment-related toxicities patients with advanced breast cancer. This study aims evaluate the impact of timing dose on progression-free survival (PFS) overall (OS) a real-world cohort. Methods: single-center, retrospective included treated or palbociclib between 2019 2023 at cancer center Turkey. drug-related were recorded, outcomes analyzed. Patients categorized...
Abstract Pancreatic carcinoma is one of the most lethal cancers and absence efficient therapeutic strategies results in poor prognosis. Transcriptional dysregulation due to alterations KRAS MYC impacts initiation, development, survival this tumor type. Using patient-derived xenografts pancreatic driven by oncogenic transcription, we show that co-inhibition Topoisomerase 1 (TOP1) bromodomain containing protein 4 (BRD4) synergistically induce regression through targeting promoter...