A5001917326- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Cellular Mechanics and Interactions
- Hydrogels: synthesis, properties, applications
- Biochemical and Structural Characterization
- Osteoarthritis Treatment and Mechanisms
- Silk-based biomaterials and applications
- Cell Adhesion Molecules Research
University of Washington
2024
University of Colorado System
2020
University of Colorado Boulder
2020
Abstract While direct cell transplantation holds great promise in treating many debilitating diseases, poor survival and engraftment following injection have limited effective clinical translation. Though injectable biomaterials offer protection against membrane‐damaging extensional flow supply a supportive 3D environment vivo that ultimately improves retention therapeutic costs, most are created from synthetic or naturally harvested polymers immunogenic and/or chemically ill‐defined. This...
Abstract Biomechanical contributions of the extracellular matrix underpin cell growth and proliferation, differentiation, signal transduction, other fate decisions. As such, biomaterials whose mechanics can be spatiotemporally altered‐ particularly in a reversible manner‐ are extremely valuable for studying these mechanobiological phenomena. Herein, poly(ethylene glycol) (PEG)‐based hydrogel model consisting two interpenetrating step‐growth networks is introduced that independently formed...
Adaptable dynamic covalent crosslinks temporally modulate the biophysical transmission of physiologically relevant compressive strains to encapsulated chondrocytes for cartilage tissue engineering.
Abstract Biomechanical contributions of the ECM underpin cell growth and proliferation, differentiation, signal transduction, other fate decisions. As such, biomaterials whose mechanics can be spatiotemporally altered – particularly in a reversible manner are extremely valuable for studying these mechanobiological phenomena. Herein, we introduce poly(ethylene glycol) (PEG)-based hydrogel model consisting two interpenetrating step-growth networks that independently formed via largely...