A5050043151- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Escherichia coli research studies
- Blood groups and transfusion
- Viral gastroenteritis research and epidemiology
- Gut microbiota and health
- Vibrio bacteria research studies
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- HIV Research and Treatment
- Advanced Proteomics Techniques and Applications
- Galectins and Cancer Biology
- Immunotherapy and Immune Responses
VA Salt Lake City Healthcare System
2022
University of Utah
2022
Frederick National Laboratory for Cancer Research
2013-2018
National Cancer Institute
2013-2018
Center for Cancer Research
2013-2018
Traumatic brain injury (TBI) was common among US service members deployed to Iraq and Afghanistan. Although there is some evidence suggest that TBI increases the risk of cardiovascular disease (CVD), prior reports were predominantly limited cerebrovascular outcomes. The potential association with CVD has not been comprehensively examined in post-9/11-era veterans.To determine between subsequent veterans.This a retrospective cohort study conducted from October 1, 1999, September 30, 2016....
Development of an effective vaccine targeting tumor associated carbohydrate antigens (TACAs) is appealing approach toward immunotherapy. While much emphasis has been typically placed on generating high antibody titers against the immunizing antigen, impact immunogen design diversity TACA-specific antibodies elicited overlooked. Herein, we report that structure can significantly breadth and magnitude humoral responses. Vaccine constructs induced diverse TACA-binding provided stronger...
Enterotoxigenic Escherichia coli (ETEC) infections are highly prevalent in developing countries, where clinical presentations range from asymptomatic colonization to severe cholera-like illness. The molecular basis for these varied presentations, which may involve strain-specific virulence features as well host factors, has not been elucidated. We demonstrate that, when challenged with ETEC strain H10407, originally isolated a case of illness, blood group A human volunteers developed...
Serum antibodies that recognize carbohydrate antigens play a fundamental role in immune defense, homeostasis, and autoimmunity. In addition, they serve as potential biomarkers for variety of medical applications. For most anti-glycan found human serum, however, the origins, regulation, biological significance are not well understood. Antibody subpopulations relevant to particular process or disease often difficult identify from myriad present serum. While prior studies have examined IgG...
Information about specificity and affinity is critical for use of carbohydrate-binding antibodies. Herein, we evaluated eight monoclonal antibodies to the blood group A (BG-A) antigen. Antibodies 87-G, 9A, HE-10, HE-24, HE-193, HE-195, T36 Z2A were profiled on a glycan microarray assess specificity, relative influence density recognition. Our studies highlight several noteworthy recognition properties. First, most bound GalNAcα1–3Gal BG-A trisaccharide nearly as well larger oligosaccharides....
Background: The HIV-1 envelope is covered with glycans that provide structural integrity and protect conserved regions from host antibody responses. However, these are often the target of broadly neutralizing antibodies (bNAbs) emerge in some HIV-infected individuals. We aimed to determine whether antiglycan IgG a general response infection or specific individuals who develop bNAbs. Methods: binding was assessed using arrays contained 245 unique components including N-linked carbohydrates,...