A5053222433- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Monoclonal and Polyclonal Antibodies Research
- Immune cells in cancer
- Liver physiology and pathology
- Lymphoma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- PI3K/AKT/mTOR signaling in cancer
- T-cell and B-cell Immunology
- Liver Disease Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Receptor Mechanisms and Signaling
- FOXO transcription factor regulation
- Fibroblast Growth Factor Research
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Single-cell and spatial transcriptomics
- Machine Learning in Bioinformatics
- Bioinformatics and Genomic Networks
- Extracellular vesicles in disease
- Clusterin in disease pathology
- Microscopic Colitis
Compugen (Israel)
2013-2024
NK cell cytotoxicity is controlled by numerous inhibitory and activating receptors. Most of the receptors bind MHC class I proteins are expressed in a variegated fashion. It was recently shown that TIGIT, new protein T cells binds to PVR PVR-like inhibits activity indirectly through manipulation DC activity. Here, we show TIGIT all human cells, it PVRL2 but not PVRL3 directly its ITIM. Finally, counter NK-mediated killing tumor protects normal from thus providing an "alternative self"...
G-protein-coupled receptors (GPCRs) represent an important group of targets for pharmaceutical therapeutics. The completion the human genome revealed a large number putative GPCRs. However, identification their natural ligands, and especially peptides, suffers from low discovery rates, thus impeding development therapeutics based on these potential drug targets. We describe novel GPCR ligands encrypted in proteome. Hundreds peptide were predicted by machine learning algorithms. In vitro...
Abstract The B7-like protein family members play critical immunomodulatory roles and constitute attractive targets for the development of novel therapies human diseases. We identified Ig-like domain–containing receptor (ILDR)2 as a with robust T cell inhibitory activity, expressed in immune cells immune-privileged inflamed tissues. A fusion protein, consisting ILDR2 extracellular domain an Fc fragment, that binds to putative counterpart on activated showed beneficial effect collagen-induced...
Blocking conformational changes in biologically active proteins holds therapeutic promise. Inspired by the susceptibility of viral entry to inhibition synthetic peptides that block formation helix–helix interactions envelope proteins, we developed a computational approach for predicting interacting helices. Using this approach, which combines correlated mutations analysis and Fourier transform, designed target gp96 clusterin, 2 secreted chaperones known shift between inactive conformations....
Abstract Cancers that are poorly immune infiltrated pose a substantial challenge, with current immunotherapies yielding limited clinical success. Stem-like memory T cells (TSCM) have been identified as subgroup of possess strong proliferative capacity and can expand differentiate following interactions dendritic (DCs). In this study, we explored the pattern expression recently discovered inhibitory receptor poliovirus receptor-related immunoglobulin domain protein (PVRIG) its ligand, ligand...
The Met receptor tyrosine kinase and its ligand, hepatocyte growth factor/scatter factor (HGF/SF), are involved in a wide range of biological activities, including cell proliferation, motility, invasion, angiogenesis. HGF/SF-Met signaling pathway is frequently activated variety cancers, uncontrolled activation correlates with highly invasive tumors poor prognosis. In this study, we investigated the inhibitory effect novel soluble splice variant on pathway.Using our alternative splicing...
### O1 Combinatorial CD8+ and PD-L1+ cell densities correlate with response improved survival in non-small lung cancer (NSCLC) patients treated durvalumab #### Sonja Althammer1, Keith Steele2, Marlon Rebelatto2, Tze Heng Tan1, Tobias Wiestler1, Guenter Schmidt1, Brandon Higgs2, Xia
In a screening effort based on algorithmic predictions for novel G‐protein‐coupled receptor (GPCR) peptide activators, we were able to identify and examine two peptides (P59 P74) which are short, linear, derived from natural, previously unidentified precursor protein containing collagen‐like repeat. Both seemed show an apparent cAMP‐related effect CHO‐K1 cells transiently transfected with either LGR7 or LGR8, usually after treatment cAMP‐generating forskolin, compared the same treated...
Abstract The immunoglobulin-like domain containing receptor 2 (ILDR2), a type I transmembrane protein belonging to the B7 family of immunomodulatory receptors, has been described induce an immunosuppressive effect on T-cell responses. Besides its expression in several nonlymphoid tissue types, we found that ILDR2 was also expressed fibroblastic reticular cells (FRC) stromal part lymph node. These immunoregulatory were located zone and essential for recruitment naïve T activated dendritic...
Abstract Background: While blockade of the CTLA4 and PD1 pathways has emerged as an effective treatment cancer, majority patients do not derive long term benefit. This provides a rationale for identifying targeting additional checkpoints. Employing our unique computational algorithms, we identified PVRIG, new member B7/CD28 family. We report here expression pattern, functional characterization, anti-tumor activity blocking antibodies PVRIG well characterization KO mice. Materials Methods: is...
Meeting abstracts Members of the B7/CD28 family immune checkpoints, such as CTLA4, PD1 and PDL-1, play critical roles in T cell regulation have emerged promising drug targets for cancer immunotherapy. We hypothesize that additional novel members a role
Abstract Poorly immune infiltrated cancers pose a significant challenge, with current immunotherapies yielding limited clinical success. Stem-like memory T cells (TSCM) have been identified as cell subgroup which possess enhanced proliferative capacity that could expand and differentiate upon dendritic (DCs) priming. In this study we investigated the expression of recently discovered inhibitory receptor PVRIG its ligand, PVRL2, in tumor microenvironment (TME). Leveraging single RNA...
<div>Abstract<p>Cancers that are poorly immune infiltrated pose a substantial challenge, with current immunotherapies yielding limited clinical success. Stem-like memory T cells (T<sub>SCM</sub>) have been identified as subgroup of possess strong proliferative capacity and can expand differentiate following interactions dendritic (DCs). In this study, we explored the pattern expression recently discovered inhibitory receptor poliovirus receptor-related immunoglobulin...
<div>Abstract<p>Cancers that are poorly immune infiltrated pose a substantial challenge, with current immunotherapies yielding limited clinical success. Stem-like memory T cells (T<sub>SCM</sub>) have been identified as subgroup of possess strong proliferative capacity and can expand differentiate following interactions dendritic (DCs). In this study, we explored the pattern expression recently discovered inhibitory receptor poliovirus receptor-related immunoglobulin...
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