A5029836209- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Cell Adhesion Molecules Research
- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- S100 Proteins and Annexins
- Radiomics and Machine Learning in Medical Imaging
- Blood disorders and treatments
- Pancreatic and Hepatic Oncology Research
- Nanoplatforms for cancer theranostics
- Traumatic Brain Injury Research
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
University of Pennsylvania
2022-2025
Hospital of the University of Pennsylvania
2023
Non-invasive prognostic biomarkers to inform clinical decision-making are an urgent unmet need for the management of patients with glioblastoma (GBM). We previously showed that higher circulating cell-free DNA concentration [ccfDNA] is associated worse survival in GBM. However, biology underlying this unknown. prospectively enrolled 129 treatment-naïve GBM blood drawn prior initial resection (baseline) and at time first post-radiotherapy MRI. performed ccfDNA methylation deconvolution...
Abstract While high circulating tumor DNA (ctDNA) levels are associated with poor survival for multiple cancers, variant-specific differences in the association of ctDNA and have not been examined. Here we investigate KRAS (ctKRAS) associations overall progression-free (OS/PFS) first-line metastatic pancreatic ductal adenocarcinoma (mPDAC) patients receiving chemoimmunotherapy (“PRINCE”, NCT03214250), an independent cohort standard care (SOC) chemotherapy. For PRINCE, higher baseline plasma...
Glioblastoma is a highly heterogeneous brain tumor, posing challenges for precision therapies and patient stratification in clinical trials. Understanding how genetic mutations influence tumor imaging may improve management treatment outcomes. This study investigates the relationship between features, spatial patterns of location, alterations IDH-wildtype glioblastoma, as well likely sequence mutational events. We conducted retrospective analysis 357 glioblastomas with pre-operative...
<p>Supplemental Figure 1. Patients and assays Supplemental 2. Survival analysis at baseline post-radiation 3. Correlative of all ccfDNA deconvolution subsets with [ccfDNA]. 4. Analysis % neutrophil tissue DNA pre-operative steroids. 5. [citH3]. 6. 7. [citH3], steroid dose, tumor volume. 8. by exposure. 9. Percent [citH3] time first MRI. 10. total [ccfDNA] 11. Molecular sub-type Clusters 1 2 from plasma differential methylation results. 12. Unsupervised clustering data, methylation,...
<div>AbstractPurpose:<p>Noninvasive prognostic biomarkers to inform clinical decision-making are an urgent unmet need for the management of patients with glioblastoma (GBM). We previously showed that higher circulating cell-free DNA (ccfDNA) concentration is associated worse survival in GBM. However, biology underlying this unknown.</p>Experimental Design:<p>We prospectively enrolled 129 treatment-naïve GBM blood drawn prior initial resection (baseline) and at time...
Recurrent gliomas are therapeutically challenging diseases with few treatment options available. One area of potential therapeutic vulnerability is the presence targetable oncogenic fusion proteins. To better understand clinical benefit routinely testing for proteins in adult glioma patients, we performed a retrospective review 647 patients who underwent surgical resection at our center between August 2017 and May 2021 whose tumors were analyzed an in-house transcript panel. Fifty-two (8%)...
Abstract Glioblastoma (GBM) is well-known for its molecular and spatial heterogeneity, which poses a challenge precision therapies clinical trial stratification. Here, in comprehensive radiogenomics study of 358 GBMs, we investigated the associations between imaging characteristics tumors with their cancer gene mutation status, as well cross-sectionally inferred likely order mutational events. We show that cross-validated machine learning analysis multi-parametric MRI scans results...
Abstract BACKGROUND We have previously shown that higher concentrations of plasma cell free DNA (cfDNA), both at baseline and following chemoradiotherapy, are associated with worse survival in GBM. Because only scant amounts GBM-derived cfDNA shed into the peripheral circulation, we sought to determine predominant source prognostic these patients hypothesized this may help unravel mechanism underlying association high survival. METHODS Plasma was obtained for 126 prior resection newly...