A5100844472- Circular RNAs in diseases
- MicroRNA in disease regulation
- Nuclear Receptors and Signaling
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Conducting polymers and applications
- interferon and immune responses
- RNA modifications and cancer
- Cancer Research and Treatments
- Perovskite Materials and Applications
- Viral Infectious Diseases and Gene Expression in Insects
- CAR-T cell therapy research
- MXene and MAX Phase Materials
- Organic Electronics and Photovoltaics
- Liver Disease Diagnosis and Treatment
- Electromagnetic wave absorption materials
- Stress Responses and Cortisol
- Power Systems and Renewable Energy
- Advanced Sensor and Energy Harvesting Materials
- Functional Brain Connectivity Studies
- Tactile and Sensory Interactions
- Cancer, Lipids, and Metabolism
- Quantum Dots Synthesis And Properties
- Child Abuse and Trauma
- Microgrid Control and Optimization
University of Science and Technology of China
2024-2025
Yunnan University
2024
Harbin Institute of Technology
2024
Guangzhou University
2024
China Agricultural University
2024
Sansure Biotech (China)
2023
Zhejiang Sci-Tech University
2007-2018
Army Medical University
2010
Southwest Hospital
2010
Background: microRNA-122 (miR-122) plays an important role in both of hepatic physiology and pathology. Downregulation miR-122 was reported human primary hepatocellular carcinoma (HCC) restoration could suppress the growth cancer cells. In this study, we presented a novel strategy for therapy based on gene transfer by adenoviral vector. Methods: We generated recombinant vector expressing (Ad-miR122). The expression measured quantitative Real-Time PCR (qRT-PCR). Cell survival rate determined...
Metal halide perovskites (MHPs) have excellent characteristics and present great potential in a broad range of applications such as solar cells, light‐emitting diodes, photodetectors. However, the light stability devices remains an unresolved issue has received research attention. Under illumination, MHPs exhibit various anomalous phenomena, photoluminescence (PL) enhancement, defect curing, PL blinking, phase segregation. These phenomena are commonly considered intimately correlated with...
<p>Figures S1 to S6, Table S1, and S2</p>
<p>The information of tissue samples from 73 liver cancer patients.</p>
<p>Untargeted lipidomics analysis in Control and circEPB41(2) knockdown cells</p>
<p>List of H3K9ac Peaks in Control and circEPB41(2) Knockdown Cells</p>
<p>Overlapping Genes with Decreased H3K9ac Deposition and Down-regulated Expression upon circEPB41(2) Knockdown</p>
<p>Targeted lipidomics analysis in Control and circEPB41(2) knockdown cells</p>
<div>Abstract<p>The tumor microenvironment plays a pivotal role in the metabolic reprogramming of cancer cells. A better understanding underlying mechanisms regulating metabolism could help identify potential therapeutic targets. Here, we identified circEPB41(2) as metabolically regulated circular RNA that mediates lipid hepatocellular carcinoma (HCC). was induced response to glucose deprivation via HNRNPA1-dependent alternative splicing. Upregulation led enhanced lipogenic gene...
<p>Figures S1 to S6, Table S1, and S2</p>
<p>List of H3K9ac Peaks in Control and circEPB41(2) Knockdown Cells</p>
<p>Targeted lipidomics analysis in Control and circEPB41(2) knockdown cells</p>
<p>Overlapping Genes with Decreased H3K9ac Deposition and Down-regulated Expression upon circEPB41(2) Knockdown</p>
<p>The information of tissue samples from 73 liver cancer patients.</p>
<p>Untargeted lipidomics analysis in Control and circEPB41(2) knockdown cells</p>
PEDOT:PSS/Si heterojunction solar cells (HSCs) with simple preparation process and low production costs has attracted a lot of attention. The adjustable color good stability devices will greatly expand...
Abstract Purpose: Recent studies showed that oncolytic adenoviruses not only have capacity for destruction of tumors but also can be used as potential vectors to express therapeutic genes therapy cancer. However, better specificity and mode transgene expression are required improve the efficacy safety if this vector is applied clinical application. Experimental Design: In study, we created adenoviral replication-based system by replacement 6.7K/gp19K E3 with EGFP IL-24 so transgenes should...
The constitutive activation of signal transducer and activator transcription 3 (STAT3) participates in carcinogenesis through up-regulation genes encoding apoptosis inhibitors cell cycle regulators, such as Bcl-xL, cyclins D1 D2, c-myc. Suppressor cytokine signaling (SOCS3) is one the negative regulators frequently silenced diverse cancers. In this study, we explored whether restoration SOCS3 by oncolytic adenoviral vectors could inhibit Janus kinase/STAT pathway suppress tumor growth. Our...
Lectins exist widely in marine bioresources such as bacteria, algae, invertebrate animals and fishes. Some purified lectins have been found to elicit cytotoxicity cancer cells. However, there are few reports describing the cytotoxic effect of on cells through virus-mediated gene delivery. We show here that a replication-deficient adenovirus-carrying encoding Haliotis discus sialic acid binding lectin (Ad.FLAG-HddSBL) suppressed cell proliferation by inducing apoptosis, compared control virus...
The photoelectric characteristics of poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) films significantly affect the power conversion efficiency and stability Si/PEDOT:PSS hybrid solar cells. In this paper, we investigated PEDOT:PSS modification with alcohol ether solvents (dipropylene glycol methyl (DPM) propylene phenyl (PPH)). reduction PSS content transformation PEDOT chain from benzene to a quinone structure in induced by doping DPM or PPH are reasons for improved...
AbstractBackground: Hepatocellular carcinoma (HCC) is one of the most difficult tumors to be treated. Overexpression human telomerase reverse transcriptase (hTERT) and dysfunction retinoblastoma (RB) have been implicated in HCC. Oncolytic viruses used as targeting therapy for different malignancies. In study, we engineered oncolytic adenovirus target both TERT RB pathways achieve strict tumor specificity. Methods: A double-controlled recombinant (AdCN103) was constructed by deletion 24bp CR2...