A5004346372- Geological Modeling and Analysis
- Groundwater flow and contamination studies
- Advancements in Photolithography Techniques
- Hydrocarbon exploration and reservoir analysis
- Parallel Computing and Optimization Techniques
- Cancer Immunotherapy and Biomarkers
- Geophysical Methods and Applications
- Hydrology and Watershed Management Studies
- Advanced Surface Polishing Techniques
- Prostate Cancer Treatment and Research
- Image Processing and 3D Reconstruction
- Geological formations and processes
- Soil Geostatistics and Mapping
- Lung Cancer Treatments and Mutations
- Prostate Cancer Diagnosis and Treatment
- Electron and X-Ray Spectroscopy Techniques
- Seismic Imaging and Inversion Techniques
- Optical Coatings and Gratings
- Advanced Radiotherapy Techniques
- Cloud Computing and Resource Management
- Geological Studies and Exploration
- Hydraulic Fracturing and Reservoir Analysis
- Geology and Paleoclimatology Research
- Economic and Financial Impacts of Cancer
- Distributed and Parallel Computing Systems
Geological Survey of Canada
2013-2024
Méditerranée Infection Foundation
2024
Institut de Médecine Tropicale du Service de Santé des Armées
2024
Hôpital Européen
2015-2023
Natural Resources Canada
2012-2023
UCLouvain
2011-2023
Sorbonne Université
2023
Développement Economique Longueuil
2022
Neuroscience Institute
2018
Centre Hospitalier de l’Université de Montréal
2015
In humans, nutrient deprivation and extreme endurance exercise both activate autophagy. We hypothesized that cumulating fasting cycling would potentiate activation of autophagy in skeletal muscle. Well-trained athletes were divided into control (n = 8), low-intensity (LI, n high-intensity (HI, 7) groups submitted to fed sessions. Muscle biopsy samples obtained from the vastus lateralis before, at end, 1 h after a 2 LI or HI bout exercise. Phosphorylation ULK1(Ser317) was higher (P < 0.001)....
EVIDENS is an ongoing, prospective, non-interventional study evaluating the effectiveness and safety of nivolumab in lung cancer patients France (ClinicalTrials.gov NCT03382496).Adults with a pathologically confirmed diagnosis initiating treatment were recruited from 146 sites France. This analysis included only non-small cell (NSCLC) who received ≥1 infusion, evaluated patient characteristics at time initiation its after median follow-up 18 months.A total 1,420 NSCLC included, most whom had...
Airborne electromagnetics (AEM) is a key tool for 3D subsurface imaging, enabling fast, efficient collection of large datasets hydrogeological studies (Deleersnyder et al., 2023; Madsen 2022). Combined with geostatistical modelling techniques, AEM data generates geologically realistic, data-consistent models (Hermans 2015). Geostatistics integrates diverse data, captures geological variability, and addresses parameter uncertainties. This study inversion results the Markov-type categorical...
Highlights•Median overall survival (OS) was 11.3 months and similar across the 3 countries.•OS rates were 49 % at 1 year 28 2 years for total study population.•OS ≈20 in ECOG PS ≥ 2, liver, bone metastasis subgroups.•Median OS independent of age prior lines therapy.•Nivolumab effectiveness real-world settings consistent with phase trials.AbstractObjectivesImmune checkpoint inhibitors have become standard care metastatic non–small-cell lung cancer (NSCLC) progressing during or after...
Abstract Background and Objectives Most research studies on the effects of repeated plasma donation are observational with different study limitations, resulting in high uncertainty link between health consequences. Here, we prospectively investigated safety intensive or less protocols. Materials Methods Sixty‐three male subjects participated this randomized controlled trial were divided into low‐frequency (LF, once/month, n = 16), high‐frequency (HF, three times/month, very (VHF, two...
The lifetime of Mo/Si multilayer-coated projection optics is one the outstanding issues on road commercialization extreme-ultraviolet lithography (EUVL). application multilayer in EUVL requires both sufficient radiation stability and also highest possible normal-incidence reflectivity. A serious problem conventional high-reflective multilayers capped by silicon considerable degradation reflective properties due to carbonization oxidation surface layer under exposure EUV radiation. In this...
A comprehensive hydrogeological study has been conducted in the Chaudière River watershed (6695 km2) located south of St. Lawrence River, near Québec City. Updated maps simplified bedrock geology and surficial sediments are presented together with newly generated regional potentiometric surface, spatial distribution annual infiltration rate encountered groundwater types. Detailed analyses hydraulic conductivity, use, salinity sources isotopic signatures conducted. At end, a conceptual model...
Ambient air pollution is recognized as a major risk factor for chronic obstructive pulmonary disease (COPD) which the third leading cause of death worldwide. We examined whether variations in daily outdoor pollutants levels were associated with excess hospital emergency room visits (ERV) acute exacerbation COPD (AECOPD). This two-center ecological cohort study was conducted Amiens, France. collected all consecutive ERV AECOPD throughout 2017 and developed single pollutant models to assess...
Acute hypoxia has previously been suggested to potentiate resistance training-induced hypertrophy by activating satellite cell-dependent myogenesis rather than an improvement in protein balance human. Here, we tested this hypothesis after a 4-week hypoxic vs normoxic training protocol. For that purpose, 19 physically active male subjects were recruited perform 6 sets of 10 repetitions one-leg knee extension exercise at 80% 1-RM 3 times/week for 4 weeks normoxia (FiO2 : 0.21; n = 9) or 0.135,...
The extreme-ultraviolet (EUV)-induced oxidation of Mo/Si multilayer mirrors was characterized by several methods: EUV reflectivity, x-ray photoelectron spectroscopy, small-angle reflectometry, atomic force microscopy, and scattering measurements. Based on the results different investigation techniques, an model developed to explain degradation under radiation.
ABSTRACT Objectives To collect data on 1) haematological and biochemical markers, 2) physiological exercise-related parameters 3) adverse events to get a comprehensive picture of the safety intensive or less plasma donation protocols. Methods Sixty-three male subjects participated in this randomized controlled trial were divided into low-frequency (LF, 1x/month, n=16), high-frequency (HF, 3x/month, very (VHF, 2x/week, n=16) placebo (P, n=15) group. Biochemical, haematological, clinical,...
Shear-wave velocity of the top 30 m, VS30, is commonly used for prediction seismic site response. This paper presents development, validation and uncertainty assessment a regional VS30 model based on combination simplified 3D geology statistically representative values. Results identify soft marine sediments in deep sedimentary basins as zones most susceptible to shaking. Compared available urban-scale zonation studies, showed success rate roughly 64% predicting local category. The standard...
Most applications of Mo/Si multilayer optics in Extreme ultraviolet lithography (EUVL) require a high normal incidence reflectivity. Using dc magnetron sputtering we achieved R = 68.8 % @ λ 13.45 nm. High-reflective Mo/Si/C and high-temperature stable Mo/C/Si/C mirrors with reflectivity 69.6 61.0 at 13.5 nm were developed. Microstructure optical properties the multilayers have been investigated by small large angle Cu-Kα scattering characterized EUV Beside periodic design, increased as well...
The effect of elevated temperatures on the optical and structural stability MoSi<sub>2</sub>/Si Mo/C/Si/C multilayer coatings was investigated. mirrors were designed for normal-incidence reflectivity at a wavelength about 13.5 nm. multilayers deposited by dc-magnetron sputtering subsequently annealed 400 °C 500 1, 10 100 hours. X-ray scattering, transmission electron microscopy, atomic force microscopy measurements used characterization structures. We achieved maximal reflectivities 41.2 %...
Current trends in computer architecture show that we are aiming toward more cores and even heterogeneity. As an extensive knowledge of processor's internals cannot be a prerequisite to their programming for the sake portability, these systems necessitate compilation flow evolve cope with heterogeneity issues. This is so true embedded systems. In this paper, how start from specific Intermediate Representation (IR) explore configuration space program-part mappings on heterogeneous targets...