A5054139748- Cancer, Hypoxia, and Metabolism
- Chronic Lymphocytic Leukemia Research
- Genomics and Chromatin Dynamics
- Drug-Induced Adverse Reactions
- Cancer Mechanisms and Therapy
- Chronic Myeloid Leukemia Treatments
- Chromatin Remodeling and Cancer
- Urticaria and Related Conditions
- Racial and Ethnic Identity Research
- Lipoproteins and Cardiovascular Health
- Health Systems, Economic Evaluations, Quality of Life
- Trauma and Emergency Care Studies
- Immunotoxicology and immune responses
- Statistical Methods and Inference
- Religion, Spirituality, and Psychology
- Gastrointestinal Tumor Research and Treatment
- Migration, Health and Trauma
- Contact Dermatitis and Allergies
- Healthcare Policy and Management
- Cancer-related Molecular Pathways
- Metabolism, Diabetes, and Cancer
- Advanced Causal Inference Techniques
- Mast cells and histamine
- Drug Transport and Resistance Mechanisms
- Multiple Myeloma Research and Treatments
Northwestern University
2019-2024
Medical University of South Carolina
2023
University of Illinois Chicago
2023
Illinois College
2023
University of California Davis Medical Center
2021-2022
Mayo Hospital
2021
United States Marine Corps
2021
University of Pennsylvania
2011
The protein post-translational modification (PTM) in host cells can be rewritten by bacterial enzymes and represents an unprecedented mechanism the communication between intestinal flora host. Although Akkermansia muciniphila has been widely investigated as a probiotic blunts colitis-associated tumourigenesis mice, there is little understanding regarding whether A. involved PTM of colorectal cancer (CRC). This study investigates how engages CRC.The secreting extracellular vesicles from...
Constitutive activation of the transcription factor STAT3 (signal transducer and activator 3) contributes to malignancy many cancers such as hepatocellular carcinoma (HCC) is associated with poor prognosis. activity increased by reversible palmitoylation Cys 108 palmitoyltransferase DHHC7 (encoded ZDHHC7 ). Here, we investigated consequences S-palmitoylation in HCC. Increased abundance HCC cases was prognosis, revealed bioinformatics analysis patient data. In HepG2 cells vitro,...
Bupropion is an oral antidepressant that commonly used to treat various mood disorders. Its therapeutic mechanism of action results from inhibiting the reuptake norepinephrine and dopamine. generally well-tolerated patients usually experience no side effects or mild adverse events. Rarely, hypersensitivity reactions bupropion, such as urticaria, have been observed. However, prevalence delayed onset bupropion-associated urticaria may not be properly reflected in literature due misdiagnosis...
Vitiligo is a skin condition that causes loss of pigmentation, resulting in hypopigmented and depigmented patches on the skin. has been associated with many autoimmune conditions. A 27-year-old female history vitiligo had clinical presentation laboratory studies were consistent incipient hypothyroidism. The relationship between vitiligo, hypothyroidism, other conditions discussed.
Objective: To identify students’ perception of the effectiveness ComPaCT tool when delivered online. Study Design: Survey Questionnaire. Setting: Department Surgery, Islamic International Medical College. Period: June 2020. Methods: A survey questionnaire was designed and distributed amongst final year students who had experienced both in a clinical setting Likert scale responses were collected based on components with two open-ended questions strengths weaknesses use Results: 89.7% agreed...
Abstract The multi-subunit chromatin remodeling complex SWI/SNF 1–3 is highly conserved from yeast to humans and plays critical roles in various cellular processes including transcription DNA damage repair 4, 5 . It uses the energy ATP hydrolysis remodel structure by sliding evicting histone octamer 6–10 , creating regions that become accessible other essential protein complexes. However, our mechanistic understanding of activity largely hindered lack a high-resolution any this family. Here...
Primula obconica, a household plant originally found in China that was introduced Europe the 1880s, has been reported to cause plant-induced contact dermatitis (CD). The condition more commonly is and less frequently United States, where not included patch testing protocols. Clinical features of P obconica CD can include facial hand as well fingertip dermatitis. main allergens known these findings are primin miconidin. Treatment mainly involves avoiding with applying topical steroid.
Thalidomide was initially developed as a sedative; subsequently, its use expanded to treat morning sickness in pregnant women. However, it later discovered be teratogenic drug that associated with embryopathy A woman is described who exposed thalidomide utero. She had several stigmata of embryopathy. Although treatment nausea and anxiety women discontinued 1961, the has been found useful agent for management systemic conditions dermatological disorders. Whether shall incorporated therapeutic...
Tyrosine kinase (TK) inhibitors (TKI) are a widely used and important class of oncologic agents with diverse well-described cutaneous adverse events (CAE).1 Avapritinib is newly approved selective TKI activity against tyrosine-protein KIT/CD117 (KIT) platelet-derived growth factor receptors (PDGFR)used in the treatment gastrointestinal stromal tumors (GIST) harboring specific exon 18 mutations.2 Here we present case an avapritinib-induced palpable purpuric eruption clinically mimicking...
Drug-associated adverse events can present with varying symptoms, such as dizziness and pruritus. A 48-year-old woman initiated rosuvastatin to treat her elevated triglycerides. She developed rosuvastatin-associated events, which included pruritus within two weeks after starting treatment. After stopping the medication, immediately cleared; diminished during next eventually resolved completely. Side effects associated are discussed. The possibility of a medication-related etiology should be...
Background: Threatened abortion is a common complication of pregnancy. In order to prevent miscarriage progesterone in various forms administered patients. This done allow pregnancy proceed further beyond twenty week gestation. Aim: To compare gravibinan (injected) with utrogestan/cyclogest (intra vaginal administration) reduction miscarriages. Study design: Case control study Place and duration study: Department Obstetrics & Gynecologiy, Mohtrama Benzair Bhutto Shaheed Medical College...