A5005027157- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- T-cell and Retrovirus Studies
- Vector-Borne Animal Diseases
- SARS-CoV-2 and COVID-19 Research
- Head and Neck Cancer Studies
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Inflammatory Biomarkers in Disease Prognosis
- CRISPR and Genetic Engineering
- Acute Myeloid Leukemia Research
- COVID-19 and healthcare impacts
- Chronic Myeloid Leukemia Treatments
- CNS Lymphoma Diagnosis and Treatment
- Pericarditis and Cardiac Tamponade
- Management of metastatic bone disease
- Retinoids in leukemia and cellular processes
- Histone Deacetylase Inhibitors Research
- Gastric Cancer Management and Outcomes
- Phytochemistry Medicinal Plant Applications
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- SARS-CoV-2 detection and testing
- Chemotherapy-induced cardiotoxicity and mitigation
- Pleural and Pulmonary Diseases
Mashhad University of Medical Sciences
2014-2024
Imam Reza Hospital
2017
Coronavirus Disease 2019 (Covid-19) is expanding worldwide. The characteristics of this infection in patients varies from country to country. To move forward, clinical data on infected are needed. Here, we report a comparison between fatalities and recovery with severe Covid-19, based demographic characteristics.Between 5 March 12 May 2020 Mashhad, Iran, 1278 4000 suspected Covid-19 were confirmed positive by real-time reverse-transcriptase-polymerase-chain-reaction assay upper respiratory...
In this randomized controlled trial, diabetic patients with foot ulcers (Wagner grades 1 and 2) were randomly assigned to conventional therapies for ulcer plus topical propolis ointment (5%; twice daily) or alone. The process of healing was observed during 4 weeks compared between the two groups regarding size, erythema, exudates, white blood cell (WBC) count erythrocyte sedimentation rate (ESR). size reduction four-week period study significantly different groups. However, difference not...
The aim of the study was to evaluate sonographic findings metastatic cervical lymph nodes and differentiating them from benign ones in patients with head neck malignancy.In this study, 14 (12 female 2 male patients; mean age, 52.8 years (with region malignancy were evaluated ultrasonographically. gray-scale parameters, which included short- long-axis lengths, shape index, presence or absence hilar echoes cystic necrosis, parenchymal echogenicity echo texture, margin, color Doppler parameter...
Introduction: Human coronavirus disease 2019 (COVID-19) is an emerging respiratory that has become pandemic worldwide. The patients have a range of mild to severe symptoms, such as pneumonia, acute distress syndrome, arrhythmia, shock, and other organs involvement. Clinical hematological evidence can serve prognostic factor detect cases COVID-19. Objectives: present study aimed evaluate parameters related the severity in COVID-19 Mashhad, Eastern Iran. Patients Methods: All individuals with...
Background: Gastric adenocarcinoma is among the most prevalent cancers associated with a high mortality rate. The multidrug neoadjuvant chemotherapy administered before and after surgery has attracted attention as beneficial standard of care for managing this malignancy. Objectives: This study assessed pathologic response patients gastric cancer who were treated fluorouracil plus leucovorin, oxaliplatin, docetaxel (FLOT). Methods: Patients pathologically confirmed without distant metastases...
Background: Adult T-cell leukemia (ATL) is one of the most important hematological malignancies caused by HTLV-I virus. The disease has a poor prognosis due to low median survival patients. Aim: Given need for effective therapeutic interventions, this study aimed investigate efficacy Hyper-CVAD and As/IFN/AZT regimens compare their performance. Methods Results: This randomized clinical trial conducted on individuals recently diagnosed with acute ATL. Individuals who tested positive in...
Background Anthracycline drugs play a fundamental role in breast cancer treatment; however, the cardiotoxicity side effects obscure advantages of treatment. Curcumin has antioxidant and anti-inflammatory effects. Materials Methods In this study, we investigated effect nanocurcumin supplementation on Doxorubicin induced Cardiotoxicity. randomized clinical trial, week before starting doxorubicin regimen for patients, control group received placebo curcumin 80 mg daily dosage nano capsules six...
Introduction: Anemia is a common complication of ESRD with different etiologies. The most cause anemia in such patients insufficient production erythropoietin by kidneys. Another possible reason copper deficiency, thus, this study aimed to evaluate the serum level among hemodialysis and without compare them healthy controls. Material Methods: A total number 56 who underwent regular due their were enrolled divided into two groups 28 according Hgb results including (Hgb<11 gr/dl) (Hgb>11...
Human T lymphotropic virus type 1 (HTLV-1) infection can cause adult T-cell lymphoblastic leukemia (ATLL), an incurable, chemotherapy-resistant malignancy. In a quest for new therapeutic targets, our study sought to determine the levels of AKT, mTOR, and PI3K in ATLL MT-2 cells, HTLV-1 infected NIH/3T3 cells (Inf-3T3), patients (Carrier, HAM/TSP, ATLL). Furthermore, effects rigosertib, wortmannin, rapamycin on PI3K/Akt/mTOR pathway inhibit proliferation were examined. The results showed that...
Abstract Background: The urgent need for the treatment of ATLL has highlighted in 18th-International Conference on Human Retrovirology-HTLV-1 (Tokyo, 2017). Therefore, this study median survival times (MST) routine therapies were evaluated context laboratory tests . Methods: In a perspective-retrospective cohort study, efficiencies therapy regimens, including interferon-alfa and zidovudine (IFN/ZDV), cyclophosphamide, vincristine, doxorubicin, dexamethasone (hyper-CVAD), lenalidomide/ZDV,...
Abstract Objectives In this study, we will investigate the effect of hydroxychloroquine on prevention novel coronavirus disease (COVID-19) in cancer patients being treated. Trial design This is a two-arm, parallel-group, triple-blind, phase 2–3 randomized controlled trial. Participants All over age 15 years from 5 types be included study. Patients with acute lymphoid and myeloid leukemias first line treated curative intent, high-grade non-Hodgkin’s lymphoma leukemia regimens, non-metastatic...
Felty syndrome is a form of rheumatoid arthritis (RA) that usually presents with neutropenia and splenomegaly. It occurs in the setting long-lasting (RA)and rarely as an early manifestation RA. Case presentation: A 47-year-old female patient presented to emergency department history fever arthralgia. She was found have splenomegaly pancytopenia. After ruling out hematologic malignancies by bone marrow biopsies, she diagnosed Rheumatoid factor (RF) cyclic citrullinated peptide antibody...
123 Background: Acute myeloid leukemia (AML) is associated with high relapse rates even in patients who achieve a complete remission initial treatment. Maintenance therapy cytotoxic agents has been considered strategy to prolong disease-free survival (DFS) and overall (OS). The lack of availability oral Azacitidine some countries limits its use. This study aimed compare the DFS OS AML without maintenance using subcutaneous cytarabine or thioguanine. Methods: retrospective cohort reviewed...
The effect of stopping or reducing the dose vincristine in diffuse large B-cell lymphoma (DLBCL) on outcome and prognosis disease is still doubt. present study aimed to investigate compare complete remission two R-CHOP treatment regimens with without reduction DLBCL patients.This retrospective was conducted newly diagnosed patients during 2018-2021. were over 18 years age, had been histologically confirmed by a pathologist, under regimen. clinical information subjects as well number courses...
<title>Abstract</title> Purpose Acute myeloid leukemia (AML) is associated with high relapse rates even in patients who achieve complete remission. The lack of availability oral azacitidine some countries has limited its use. This study aimed to compare the outcomes AML and without maintenance therapy using available drugs. Methods retrospective cohort reviewed charts treated oncology centers northeast Iran from February 2015 2021. included experienced remission following induction...