A5000210855- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neurotransmitter Receptor Influence on Behavior
- Menopause: Health Impacts and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Estrogen and related hormone effects
- Cardiac Imaging and Diagnostics
- Lipoproteins and Cardiovascular Health
- Genetic Neurodegenerative Diseases
- Hormonal Regulation and Hypertension
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Diet and metabolism studies
- Receptor Mechanisms and Signaling
- Hemodynamic Monitoring and Therapy
- Vaccine Coverage and Hesitancy
- Cardiac Ischemia and Reperfusion
- Cardiovascular Health and Disease Prevention
- Phytoestrogen effects and research
- Cardiac Health and Mental Health
- Chronic Disease Management Strategies
- Neuropeptides and Animal Physiology
- SARS-CoV-2 and COVID-19 Research
- Sleep and Wakefulness Research
- Antiplatelet Therapy and Cardiovascular Diseases
University of Birmingham
2002-2024
Guy's and St Thomas' NHS Foundation Trust
1999-2024
Guy's Hospital
2024
University of Missouri
2023
Center for Autism and Related Disorders
2019-2023
Collaborative Research Group
2022
Birmingham City University
2020
Shanghai Genon Biological Products (China)
2020
Cancer Research UK Clinical Trials Unit
2020
Albany Molecular Research (United States)
2020
Many patients fail to attend cardiac rehabilitation. Attempts identify sociodemographic or clinical predictors of non-attendance have not been very successful; therfore, this study aimed determine whether the illness beliefs held during hospitalisation by who had suffered acute myocardial infarction undergone coronary artery bypass graft surgery could predict rehabilitation attendance.152 were prospectively studied whom 41% attended at six months.In addition being older, less aware their...
Neurones of the globus pallidus (GP) have been classified into three subgroups based on visual inspection current clamp electrophysiological properties and morphology biocytin-filled neurones. Type A neurones (132/208; 63 %) were identified by presence time- voltage-dependent inward rectifier (Ih) low-threshold calcium (It) giving rise to anodal break depolarisations. These cells quiescent or fired regular spontaneous action potentials followed biphasic AHPs. Current injection evoked...
Changes in drivers of academic roles within higher education institutions globally have resulted increased proportions academics focused (EF) posts. International and UK research suggests that EF can experience dissatisfaction with career progression the perceived value their work, including those research-intensive universities. Previous was conducted prior to introduction TEF which has altered landscape. Therefore, it timely examine current universities through a theoretical lens...
The role of enkephalin and the opioid receptors in modulating GABA release within rat globus pallidus (GP) was investigated using whole-cell patch recordings made from visually identified neurons. Two major GP neuronal subtypes were classified on basis intrinsic membrane properties, action potential characteristics, presence anomalous inward rectifier ( I h ), anode break depolarizations. μ receptor agonist [ d -Ala 2 - N -Me-Phe 4 -Glycol 5 ]-enkephalin (DAMGO) (1 m ) reduced A...
Whilst the FDA-approved anorectic, lorcaserin and various 5-hydroxytryptamine (5-HT)6 receptor antagonists reduce feeding, a direct assessment of their impact upon feeding behaviour is less clear. We therefore examined action clinical-stage developmental candidate 5-HT6 antagonist, SB-742457, microstructural analysis licking behaviour. Such provides rich source information about mechanisms controlling food intake. The objective present study was to gain insight into influence 5-HT2C agonist,...
To determine the clinical utility of transvaginal sonography for diagnosis upper genital tract infection. Fifty-five women who either met Centers Disease Control and Prevention's minimal criteria acute pelvic inflammatory disease or were being seen nonclassic signs infection evaluated. During abdominal endovaginal ultrasound testing, fluid in cul-de-sac, discrete tubes with without tubal fluid, multicystic ovaries, adnexal masses noted. Upper was confirmed by laparoscopic visualization...
Patients with atherosclerotic renovascular disease (ARVD) are at increased risk of heart because the association hypertension, coronary artery disease, cardiac failure and chronic kidney (CKD). A previous echocardiographic cross-sectional study showed that only 5% patients ARVD had normal structure function baseline. In this longitudinal same patient cohort progression dysfunction factors which predict declining in were delineated.Seventy-nine available for baseline analysis, but 16 withdrew...
Motivation: Advances in MRI have increased our understanding of the human brain but are frequently limited by single modality study designs. Combining data from multiple modalities/MR contrasts can enhance complex multi-scale neural relationships that underpin behaviour. Goal(s): Our goal was to create an open-access multi-scale, multi-modal imaging database healthy brain. Approach: The Welsh Advanced Neuroimaging Database (WAND) includes micro and macro-structural, functional spectroscopic...
The cannabinoid receptor agonists Δ9-tetrahydrocannabinol (Δ9-THC) and HU-210 were compared in terms of their effects on: (1) progressive ratio (PR) responding for food, (2) free food intake. In the first experiment, food-deprived Wistar rats trained on a time-constrained (60 min) PR-5 schedule reinforcement, which response requirement incremented by five lever presses each successive reinforcer. One group received vehicle, 0.5, 1 or 3 mg/kg Δ9-THC (i.p.), three other groups (i.p.) at...