A5101754636- Phytochemistry and Biological Activities
- Bioactive Natural Diterpenoids Research
- Plant-based Medicinal Research
- Phytochemical Studies and Bioactivities
- Bacterial biofilms and quorum sensing
- Cancer-related molecular mechanisms research
- Bacterial Identification and Susceptibility Testing
- Wastewater Treatment and Nitrogen Removal
- Bacteriophages and microbial interactions
- Forest Ecology and Biodiversity Studies
- Click Chemistry and Applications
- Cancer Cells and Metastasis
- Remote Sensing in Agriculture
- Plant Reproductive Biology
- Odor and Emission Control Technologies
- Microbial Metabolism and Applications
- Pharmaceutical and Antibiotic Environmental Impacts
- Plant-Microbe Interactions and Immunity
- Cell Image Analysis Techniques
- Plant Gene Expression Analysis
- Cyclopropane Reaction Mechanisms
- Antibiotic Resistance in Bacteria
- Plant Molecular Biology Research
- Metastasis and carcinoma case studies
- Plant biochemistry and biosynthesis
First Affiliated Hospital of Henan University
2022-2024
Henan Agricultural University
2024
Qingdao University
2023
Chinese Center For Disease Control and Prevention
2023
Ministry of Natural Resources
2023
State Key Laboratory of Natural and Biomimetic Drugs
2021
Peking University
2021
Northwest A&F University
2019
Huazhong Agricultural University
2018
Shihezi University
2014-2016
The GRAS (GAI\RGA\SCL) gene family encodes plant-specific transcription factors that play crucial roles in plant growth and development, stress tolerance, hormone network regulation. Plant dwarfing symptom is mainly regulated by DELLA proteins of the subfamily. In this study, association between Paulownia witches’ broom (PaWB) was investigated. A total 79 PfGRAS genes were identified using bioinformatics methods categorized into 11 groups based on amino acid sequences. Tandem duplication...
Abstract Isoniazid (INH) is a first-line anti-tuberculosis drug used for nearly 70 years. However, the mechanism underlying side effects of INH has remained elusive. Here, we report that and its metabolites induce post-translational modification (PTM) histones, lysine isonicotinylation (K inic ), also called 4-picolinylation, in cells mice. promotes biosynthesis isonicotinyl-CoA (Inic-CoA), co-factor intracellular isonicotinylation. Mass spectrometry reveals 26 K sites histones HepG2 cells....
The nonstandard use of disinfectants can lead to the disinfectant resistance bacteria and even increase antibiotic resistance. However, compared with study resistance, studies bacterial are relatively few in number. In this study, we explored standard strain screening procedure for evaluation disinfection efficacy. Staphylococcus aureus strains different sources substrates were selected from National Pathogen Resource Center China screened that could evaluate long-term bacteriostatic effect...
Cytoplasmic male sterility (CMS) is universally utilized in cruciferous vegetables. However, the Chinese cabbage hau CMS lines, obtained by interspecific hybridization and multiple backcrosses of Brassica juncea (B. juncea) line cabbage, show obvious leaf etiolation, molecular mechanism etiolation remains elusive. Here, ultrastructural phenotypic features leaves from 1409A maintainer 1409B are analyzed. The results that chloroplasts exhibit abnormal morphology distribution. Next,...
A nano-regulator induces triple homeostasis disruption of calcium ion/nitric oxide/energy metabolism for synergetic cancer therapy.
Six metabolites (1–6), including 1 new fusaric acid derivative, designated atransfusarin (1), and 5 known compounds, (3 R,6 R)-3-benzyl-6-isopropyl-4-methylmorpholine-2,5-dione (2), daucoterol (3), adenosine (4), cerebroside B (5), 2,3-dihydroxypropyl ( Z,Z)-9,12-octadecadienate (6), were isolated from the solid culture of an endophytic Alternaria atrans MP-7, associated with medicinal plant Psidium guajava. The structure compound was elucidated by spectral data. antifungal test indicated...
Introduction The horizontal transfer of antibiotic resistance genes mediated by plasmids seriously hinders the effectiveness modern medical treatment, and thus has attracted widespread attention. Additionally, co-selection mechanism (ARGs) heavy metal (MRGs) on mobile elements may further exacerbate genes. Methods In this study, a multidrug-resistant Pseudomonas aeruginosa strain, termed BJ86 (CHPC/NPRC1.4142), was isolated from patient's sputum specimen. vitro tests for antimicrobial...
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Seven compounds(1-7) were isolated from Isodon henryi through silica gel, Sephadex LH-20, ODS, MCI column chromatography and semi-preparative HPLC. Their structures identified as isogallicacid(1), caffeic acid(2), syringic acid(3), protocatechuic acid(4), oresbiusin A(5), lophanthoside A(6), 8-hydroxypinoresinol(7), by spectroscopic techniques including HR-MS, IR, UV, NMR, ECD. Compound 1 was a new galloyl derivative. Moreover, it demonstrated significant inhibitory effect on the...
The monitoring of vegetation recovery was an important factor to evaluate the effectiveness ecological restoration open-pit mines. Lidar data can obtain horizontal and vertical structures trees that wildly used characterize 3-dimensional (3D) structure trees. In this paper, taking Ba'nan District Chongqing as a study area, high density lidar applied parameters based on marker-controlled watershed segmentation method with IPTD filtering algorithm. result showed, average tree height, diameter...
Whole genome sequencing (WGS) holds significant promise for epidemiological inquiries, as it enables the identification and tracking of pathogenic origins dissemination through comprehensive analysis. This method is widely preferred investigating outbreaks monitoring pathogen activity. However, effective utilization microbiome data remains a challenge clinical public health experts. Through National Pathogen Resource Center, we have constructed dynamic interactive online analysis platform to...
Phytochemical investigation of Isodon henryi led to the isolation two new diterpenoids, isohenolides A-B ( 1-2 ), one natural diterpenoid 3 ) and thirteen known ones 4-16 ). These diterpenoids showed various ent -kaurane skeletons, in which isohenolide A 1 was a rare 6,8-cyclo containing an unprecedented 11,15-lactone group, possessed 6/5/6/6/6/6 ring system. Their structures were confirmed by comprehensive UV, IR, HRESIMS, NMR analyses ECD calculations. Most compounds also screened for...