A5049365649- Pharmacogenetics and Drug Metabolism
- Molecular Biology Techniques and Applications
- Epigenetics and DNA Methylation
- Eicosanoids and Hypertension Pharmacology
- Immunodeficiency and Autoimmune Disorders
- Cancer therapeutics and mechanisms
- Immune Cell Function and Interaction
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetics and Neurodevelopmental Disorders
- DNA and Nucleic Acid Chemistry
- Sperm and Testicular Function
- Pharmaceutical studies and practices
- Chemical Reactions and Isotopes
- Protein Degradation and Inhibitors
- Diabetes and associated disorders
- Computational Drug Discovery Methods
- Genomics and Rare Diseases
- Melanoma and MAPK Pathways
- RNA and protein synthesis mechanisms
- Pancreatic function and diabetes
- RNA modifications and cancer
- Acute Lymphoblastic Leukemia research
- Cancer Treatment and Pharmacology
- Plant Virus Research Studies
- Diabetes Management and Research
Baylor College of Medicine
2020-2024
The development of a safe, effective, reversible, non-hormonal contraceptive method for men has been an ongoing effort the past few decades. However, despite significant progress on elucidating function key proteins involved in reproduction, understanding male reproductive physiology is limited by incomplete information genes expressed tissues, and no targets have so far reached clinical trials. To advance product development, further identification novel tract-specific leading to...
Abstract Background Ubiquitination is a post-translational modification required for number of physiological functions regulating protein homeostasis, such as degradation. The endoplasmic reticulum (ER) quality control system recognizes and degrades proteins no longer needed in the ER through ubiquitin–proteasome pathway. E2 E3 enzymes containing transmembrane domain have been shown to function control. UBE2J1 ubiquitin-conjugating enzyme reported be essential spermiogenesis at elongating...
Despite 96 million years of evolution separating humans and rodents, 11 closely related reproductive tract-specific genes in humans— SPINT3 , WFDC6 EPPIN WFDC8 WFDC9 WFDC10A WFDC11 WFDC10B WFDC13 SPINT4 WFDC3 —and the 13 orthologous mice, form highly conserved syntenic gene clusters indicative conserved, combined critical functions. Further, despite significant progress toward a nonhormonal male contraceptive targeting protein encoded by one these genes, epididymal peptidase inhibitor...