A5083549899- Epigenetics and DNA Methylation
- Ion Channels and Receptors
- Reproductive Physiology in Livestock
- Reproductive Biology and Fertility
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Sperm and Testicular Function
- Hormonal and reproductive studies
- Animal Nutrition and Physiology
- Epilepsy research and treatment
- Ubiquitin and proteasome pathways
- Neurobiology and Insect Physiology Research
- Genomics and Chromatin Dynamics
- Cancer-related gene regulation
- Plant Reproductive Biology
- Growth Hormone and Insulin-like Growth Factors
- Toxin Mechanisms and Immunotoxins
- Clinical Reasoning and Diagnostic Skills
- Animal Behavior and Welfare Studies
- Phytoestrogen effects and research
- Myasthenia Gravis and Thymoma
- Neonatal and fetal brain pathology
- Signaling Pathways in Disease
- Phytochemicals and Antioxidant Activities
- S100 Proteins and Annexins
- Peroxisome Proliferator-Activated Receptors
Baylor College of Medicine
2022-2024
University of Nebraska–Lincoln
2021-2024
Vanderbilt University Medical Center
2024
University of Wyoming
2018-2023
Wyoming Department of Education
2023
Cavendish Hospital
1988
Men or mice with homozygous serine/threonine kinase 33 (
The use of calcium supplements to prevent postmenopausal bone loss and hence osteoporosis is widespread, but the evidence for their efficacy, either alone or in combination with other treatments, contradictory. Skeletal measurements dietary intake were determined 59 healthy women, most whom within five years menopause. No correlation was found between current total body density trabecular cortical forearm vertebral bone. Dietary did not influence rate 54 women who completed 12 months active...
Abstract Background Ubiquitination is a post-translational modification required for number of physiological functions regulating protein homeostasis, such as degradation. The endoplasmic reticulum (ER) quality control system recognizes and degrades proteins no longer needed in the ER through ubiquitin–proteasome pathway. E2 E3 enzymes containing transmembrane domain have been shown to function control. UBE2J1 ubiquitin-conjugating enzyme reported be essential spermiogenesis at elongating...
Seizures are one of the most common neurologic complications seen in a neonate. Historically, phenobarbital has been agent choice, but can lead to adverse outcomes, which contributed use other agents. Levetiracetam proven great efficacy with an excellent safety profile older patients, causing interest its neonates. The objective this study was determine if levetiracetam would provide similar neonatal seizure resolution rates as phenobarbital.
Abstract Background Ovochymase 2 ( Ovch2 ) is an epididymis‐specific gene that required for male fertility. While a multitude of reproductive tract‐specific genes fertility have been identified, OVCH2 thus far the first protein contains Complement C1r/C1s, Uegf, Bmp1 (CUB) domains located in tandem C‐terminus protein. Identifying functional significance this unique domain has implications better understanding and infertility as potential contraceptive target. Objective The goals these...
Introduction: Pubertal attainment is critical to reproductive longevity in heifers. Previously, four heifer pubertal classifications were identified according of blood plasma progesterone concentrations > 1 ng/ml: 1) Early; 2) Typical; 3) Start-Stop; and 4) Non-Cycling. Early Typical heifers initiated maintained cyclicity, Start-Stop started then stopped cyclicity Non-Cycling never cyclicity. segregated into Start-Stop-Discontinuous (SSD) or Start-Stop-Start (SSS), with SSD having...
Abstract The quest for a non-hormonal male contraceptive pill men still exists. Serine protease 37 (PRSS37) is sperm-specific protein that when ablated in mice renders them sterile. In this study we sought to examine the molecular sequelae of PRSS37 loss better understand its function, and determine whether human could rescue sterility phenotype knockout (KO) mice, allowing more appropriate model drug molecule testing. To end, used CRISPR-EZ create lacking entire coding region Prss37 ,...
Abstract A population of cows with excess androstenedione (A4; High A4) in follicular fluid, arrest, granulosa cell dysfunction, and a 17% reduction calving rate was previously identified. We hypothesized that A4 the ovarian microenvironment caused arrest vascular endothelial growth factor would rescue phenotype. In trial 1, prior to culture, cortex (n = 9) had greater numbers early stage follicles (primordial) fewer later-stage compared controls 11). Culture for 7 days did not relieve this...
Follicle development from the primordial to antral stage is a dynamic process within ovarian cortex, which includes endocrine and paracrine factors somatic cells cumulus cell-oocyte communication. Little known about microenvironment how cytokines steroids produced in surrounding milieu affect follicle progression or arrest. In vitro culture of cortex enables follicles develop normalized environment that remains supported by adjacent stroma. Our objective was determine effect nutritional...
The Snell dwarf mouse exhibits impaired growth of the anterior pituitary resulting in reduced levels hormone and thyroid stimulating hormone. Ten mice 10 phenotypically normal littermates were killed at 33 days age. M. biceps brachii (a predominantly fast muscle) m. soleus relatively slow removed from each animal complete frozen transverse sections obtained. Serial reacted for various enzyme activities order to identify muscle fibre types. There was no difference total number fibres but a...
Follicle development from the primordial to antral stage is a dynamic process within ovarian cortex, which includes endocrine and paracrine factors somatic cells cumulus cell-oocyte communication. Little known about microenvironment how cytokines steroids produced in surrounding milieu affect follicle progression or arrest. In vitro culture of cortex enables follicles develop normalized environment that remains supported by adjacent stroma. Our objective was determine effect nutritional...
A previous study reported that a 400-mg dose of medroxyprogesterone acetate (MPA) reduced male reindeer aggression and blocked development secondary sexual characteristics but did not completely impair fertility. Here we have repeated protocol in two separate trials. In 2017, tissues blood samples, collected from MPA control (CTL) bulls, euthanized at 30 60 d post-treatment were used to evaluate testes histology morphometrics, cfos activity the brain androgen levels. While weight tended...
This study sought to determine if speech-language pathology graduate students found peer-to-peer teaching and experiential learning beneficial in how assess the cranial nerves. Graduate a motor speech disorders course completed an in-class nerve examination which they either portrayed clinicians or patients. Student groups utilized reflective practice approach by their peers Intensive sessions were offered almost daily for two weeks prior exam. Thirty-seven online survey about knowledge...
The Transient Receptor Potential Melastatin 8 (TRPM8) channel is a temperature-sensitive, calcium permeable ion and purported testosterone receptor. To determine how the hormone milieu influences expression of TRPM8 in gonadal tissue areas brain important for reproduction, from western white-faced cross-bred ewes, rams, gonadectomized males (wethers; n=6 per group) approximately 6 mo age were collected. mRNA was greater (P=0.01) prostate rams than wethers. Testes had (P=0.004) ovary....