A5020752223- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Catalytic Reactions
- Synthesis and Biological Evaluation
- Toxoplasma gondii Research Studies
- Synthesis of β-Lactam Compounds
- Synthesis and Reactions of Organic Compounds
- Cyclopropane Reaction Mechanisms
- Asymmetric Synthesis and Catalysis
- Organic Chemistry Cycloaddition Reactions
- Synthesis of Organic Compounds
- Synthesis of heterocyclic compounds
- Antifungal resistance and susceptibility
- Bee Products Chemical Analysis
- Research on Leishmaniasis Studies
- Chemistry and Chemical Engineering
- Click Chemistry and Applications
- Public Health in Brazil
- Plant Toxicity and Pharmacological Properties
- Hops Chemistry and Applications
- Medication Adherence and Compliance
- Chemical synthesis and alkaloids
- Plant-Microbe Interactions and Immunity
- Trypanosoma species research and implications
- Fungal Plant Pathogen Control
Universidade Federal de Pernambuco
2007-2024
Centro de Estudos e Sistemas Avançados do Recife
2019
Universidade de Pernambuco
2009
Universidade Estadual de Campinas (UNICAMP)
1995-2002
Universidade Federal do Rio de Janeiro
1993
Antibiotic resistance is considered one of the world's major public health concerns. The main cause bacterial improper and repeated use antibiotics. To alleviate this problem, new chemical substances against microorganisms are being synthesized tested. Thiazolidines compounds having many pharmacological activities including antimicrobial activities. For purpose some thiazolidine derivatives substituted at position 5 in nucleus were tested several microorganisms. Using a disc diffusion...
The aim of this study was to investigate the anti-inflammatory effects two new isoxazoline-acylhydrazone derivatives: N'-(4-methoxybenzylidene)-6-(4-nitro-benzoyl)-3a,5,6,6a-tetrahydro-4H-pyrrolo[3,2-d]isoxazole-3-carbohydrazide (R-123) and N'-(4-chlorobenzylidene)-6-(4-chlorobenzoyl)-3a,5,6,6a-tetrahydro-4H-pyrrolo[3,2-d]isoxazole-3-carbohydrazide (R-99). An air pouch induced by carrageenan used for screening best dose R-99 R-123. Using mouse model, leukocyte migration cytokine levels...
AND BIOLOGICAL IMPORTANCE.Thiosemicarbazones are a class of compounds known by their chemical and biological properties, such as antitumor, antibacterial, antiviral antiprotozoal activity.Their ability to form chelates with metals has great importance in activities.Their synthesis is very simple, versatile clean, usually giving high yields.They largely employed intermediates, the others compounds.This article survey some these characteristics showing organic medicinal chemistry.
The total syntheses of two indolizidine skeletons and the necine base (±)-platynecine were accomplished in a concise manner with good overall yields starting from common five-membered endocyclic enecarbamate. These feature [2 + 2]cycloaddition enecarbamate 5 to alkylketenes that proceeded high stereoselectivity provide an endo alkyl cycloadduct as major or only product. minor exo cycloadducts, which can be observed some 2]cycloadditions, seem derive cycloadduct, putative kinetic product, by...
Leishmaniasis is considered as one of the major neglected tropical diseases due to its magnitude and wide geographic distribution. Leishmania braziliensis, responsible for cutaneous leishmaniasis, most prevalent species in Brazil. Superoxide dismutase (SOD) belongs antioxidant pathway parasites human host. Despite differences between SOD braziliensis make this enzyme a promising target drug development efforts. No medicinal chemistry effort has been made identify LbSOD inhibitors. Herein, we...
Fourteen arylsemicarbazone derivatives were synthesized and evaluated in order to find agents with potential anticancer activity. Cytotoxic screening was performed against K562, HL-60, MOLT-4, HEp-2, NCI-H292, HT-29 MCF-7 tumor cell lines. Compounds 3c 4a active the tested cancer lines, being more cytotoxic for HL-60 line IC50 values of 13.08 μM 11.38 μM, respectively. Regarding protein kinase inhibition assay, inhibited seven different kinases strongly CK1δ/ε kinase. The studied are...
OF NOVEL ISOXAZOLYL-ARYL-HYDRAZONES.New 2-isoxazoline aldehydes were synthesized, in good yields, from cycloadduct of the 1,3-dipolar cycloaddition reaction between endocyclic enecarbamate and carboethoxyformonitrile oxide (CEFNO).Condensation these with several phenyl-hydrazines produced new isoxazolyl-aryl-hydrazones, which showed low toxicity excellent antinociceptive activity, when compared to dipyrone.The activity isoxazolyl-aryl-hydrazones was performed using acetic acid-induced mice...
PREPARATION METHODS, REACTIVITY AND BIOLOGICAL IMPORTANCE OF 4-THIAZOLIDINONES.Molecules containing the 4-thiazolidinone ring are known to possess a wide range of biological properties including antimicrobial and antiinflammatory activities among others.These compounds can be synthesized by cyclization reactions involving α-haloacetic acid or α-mercaptoacetic employed in several chemoselective reactions.Comprehensive reviews have been written on 4thiazolidinones 1961 Brown 1980 Singh et...
In a study recently published by our research group, the isoxazoline-acylhydrazone derivatives R-99 and R-123 presented promising antinociceptive activity. However, mechanism of action this compound is still unknown.This aimed to assess mechanisms involved in activity these compounds chemical models pain.Animals were orally pretreated evaluated acetic acid-, formalin-, capsaicin-, carrageenan- Complete Freund's Adjuvant (CFA)-induced pain mice. The effects after pretreatment with naloxone,...
Aim: To evaluate antifungal potential of 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hybrids based on thiosemicarbazones and thiazolidinediones against pathogenic Sporothrix species. Methods: Antifungal activity nine compounds were assessed by broth microdilution. Interactions between active itraconazole evaluated the checkerboard assay using non-wild-type isolates. Cytotoxicity was determined. Results: Four C-3 substituted analogs showed activity, unrelated to thiosemicarbazone or...
SOME N-TRYPTHOPHYL-5-BENZYLIDENE-2,4-THIAZOLIDINEDIONE AND N-TRYPTHOPHYL-5-BENZYLIDENE-RHODANINE DERIVATIVES.Derivatives of Ntryptophyl-5-benzylidene-2,4-thiazolidinedione (7a-c) and N-tryptophyl-5-benzylidene-rhodanine (7d-f) were prepared by condensation the intermediates 5 6 with different benzaldehydes, respectively.Their structural elucidation was carried through IR, 1 H NMR MS.The acute toxicity antiedematogenic activity compounds 7b,c 7e,f evaluated.The data did not reveal any sign...
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A facile and efficient method for the synthesis of a new series 1-phenylpyrazole peptidomimetics 6a-f is described.Peptide bond formation between unsaturated carboxylic acid amino residue has been achieved using benzotriazolyloxy-tris-(dimethylamino) phosphonium hexafluorophosphate (BOP) reagent triethylamine (TEA).This strategy was found to be successful obtaining pyrazole peptidomimetics.