A5029690333- Effects of Radiation Exposure
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Advanced Radiotherapy Techniques
- Inflammatory mediators and NSAID effects
- Radiation Therapy and Dosimetry
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer-related Molecular Pathways
- Estrogen and related hormone effects
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Brain Metastases and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Head and Neck Cancer Studies
- Angiogenesis and VEGF in Cancer
- Chemical Synthesis and Analysis
- Statistical Methods in Clinical Trials
- Sperm and Testicular Function
- FOXO transcription factor regulation
- Glioma Diagnosis and Treatment
- Synthesis and biological activity
- Radiation Effects and Dosimetry
- Electromagnetic Fields and Biological Effects
- Inflammasome and immune disorders
Mid Yorkshire Hospitals NHS Trust
2024
The University of Texas MD Anderson Cancer Center
1981-2016
Radiation Oncology Associates
1977-1999
The University of Texas Health Science Center at Houston
1999
Microtubules are cellular organelles with functions that include control of cell division by mitosis, morphology, and transport material within the cell. The anticancer drug paclitaxel (Taxol) promotes accelerated assembly excessively stable microtubules. Consequently, treated cells tend to become arrested in mitosis. also induces apoptotic death vitro vivo. Prior this study, relative contributions mitotic arrest apoptosis vivo antitumor effect relationship between two factors had not been...
Prostaglandins are arachidonate metabolites produced in virtually all mammalian tissues and possess diverse biologic capabilities, including vasoconstriction, vasodilatation, stimulation or inhibition of platelet aggregation, immunomodulation, primarily immunosupression (1–4). They implicated the promotion development growth malignant tumors (4–7). also involved response tumor normal to cytotoxic agents such as ionizing radiation (8). Prostaglandin production is mediated by two...
The cytotoxic effects of magnetic resonance (MR) on spermatogenesis in mice were studied. Mice exposed to a strong static field from 0.3-T MR imaging device. effect this treatment different classes spermatogenic cells was investigated by counting sperm heads at various times after exposure. Sixty-six hours continuous exposure did not produce any significant cytotoxicity these cells. This period is far longer than anticipated occupational humans. Thus, acute and subacute fields associated...
The development of “metastatic” colonies fibrosarcoma in the lungs mice after IV injection a single-cell suspension tumour cells varied with time irradiation or administration bleomycin. Most notably, there was late radiation-induced enhancement colony-forming efficiency that coincided an increase lung weight and hydroxyproline content decrease compliance. There no “spontaneous” metastases from mammary carcinoma implanted thighs animals. sequence events bleomycin similar to irradiation, but...
AbstractPurpose: A method of estimating the single-dose curve from designed multifraction experiments is described and applied to three datasets. Materials methods: The method, which non-parametric based on standard statstical regression techniques, can be used for functional endpoints are either continuous or binary. datasets concerned with wound healing mice, myelopathy in guinea pigs spermatogenesis mice. results compared fitting linear quadratic model. statistical methods Bootstrapping...
The risk of normal tissue damage imposes severe limitations on the radiotherapy malignant tumours. aim this study was to examine morphology late radiation injury with special reference microvasculature in irradiated guinea pig spinal cord. Gamma from a cobalt-60 source used irradiate lumbar region pigs. A total dose up 94.5 Gy given using 4.5 fractions. Twenty such pigs which survived more than 2 years post-irradiation were deeply anaesthetized and Mercox resin perfused through thoracic...
We have collected lab notebooks from Rod Wither's many years of experimentation, laboratories in Houston and Los Angeles, as well several his collaborators the USA overseas. The contents been digitized, this note we explain mechanism that has set up to make 'Withers Archive' available online.