A5101769675- Virology and Viral Diseases
- Cardiovascular Health and Risk Factors
- Virus-based gene therapy research
- Cardiac Health and Mental Health
- Cardiovascular Disease and Adiposity
- Respiratory viral infections research
- Neonatal Respiratory Health Research
- Viral Infections and Immunology Research
- Plant Virus Research Studies
- Influenza Virus Research Studies
- Hip disorders and treatments
- vaccines and immunoinformatics approaches
- Bacteriophages and microbial interactions
- Lower Extremity Biomechanics and Pathologies
- Breastfeeding Practices and Influences
- Immune Cell Function and Interaction
- Infant Nutrition and Health
- Orthopaedic implants and arthroplasty
Hospital Universitario Araba
2024
University of the Basque Country
2024
Osakidetza
2024
Centro de Investigación Biomédica en Red
2022-2023
Universitat de València
2023
Complejo Hospitalario de Navarra
2022
Navarre Institute of Health Research
2022
Instituto de Salud Carlos III
2022
Centro de Investigación en Sanidad Animal
2017-2021
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
2019-2021
ABSTRACT Bioengineering of viruses and virus-like particles (VLPs) is a well-established approach in the development new improved vaccines against viral bacterial pathogens. We report here that capsid major avian pathogen, infectious bursal disease virus (IBDV), can accommodate heterologous proteins to induce protective immunity. The structural units ∼70-nm-diameter T=13 IBDV are trimers VP2, which made as precursor (pVP2). pVP2 C-terminal domain has an amphipathic α helix controls VP2...
Peste des petits ruminants virus (PPRV) causes an economically important disease that limits productivity in small domestic and often affects the livestock of poorest populations developing countries. Animals survive PPRV develop strong cellular humoral responses, which are probably necessary for protection. Vaccination should thus aim at mimicking these natural responses. Immunization strategies against this morbillivirus using recombinant adenoviruses expressing PPRV-F or -H proteins can...
The toll-like receptor (TLR) family comprises both cell-surface and intracellular receptors that recognize different types of pathogen-associated molecular patterns (PAMPs) leading to the production pro-inflammatory cytokines subsequent development adaptive immunity. TLR2 is a initially thought act as bacterial sentinel but also shown number viral glycoproteins. In this study, we sought characterize role in activation immune response by peste des petits ruminants virus (PPRV), morbillivirus...
<b><i>Background/Aims:</i></b> Human milk is considered the most suitable food for infants. The potential benefits of breastfeeding can be explained by presence different growth and neurotrophic factors in human milk. This study was designed to detect some biomarkers milk, which could involved infant neurodevelopment regulation maturation neonatal intestine (brain-derived factor (BDNF), glial cell line-derived (GDNF), fibrillary acidic protein (GFAP), fibroblast 21...
<p><strong>Background</strong></p> <p>Cardio-vascular disease and depression are thought to be closely related, due shared risk factors. The aim of the study was determine association between cardio-vascular (CVR) factors depressive status in a population (55–75 years) with metabolic syndrome (MetS) from PREDIMED-Plus trial.</p> <p><strong>Methods findings</strong></p> <p>Participants were classified into three groups CVR...
Background Cardio-vascular disease and depression are thought to be closely related, due shared risk factors. The aim of the study was determine association between cardio-vascular (CVR) factors depressive status in a population (55–75 years) with metabolic syndrome (MetS) from PREDIMED-Plus trial. Methods findings Participants were classified into three groups CVR according Framingham-based REGICOR function: (1) low (LR), (2) medium (MR) or (3) high/very high (HR). Beck Depression...
<p><strong>Background</strong></p> <p>Cardio-vascular disease and depression are thought to be closely related, due shared risk factors. The aim of the study was determine association between cardio-vascular (CVR) factors depressive status in a population (55–75 years) with metabolic syndrome (MetS) from PREDIMED-Plus trial.</p> <p><strong>Methods findings</strong></p> <p>Participants were classified into three groups CVR...
Hollow protein containers are widespread in nature, and include virus capsids as well eukaryotic bacterial complexes. Protein cages studied extensively for applications nanotechnology, nanomedicine materials science. Their inner outer surfaces can be modified chemically or genetically, the internal cavity used to template, store and/or arrange molecular cargos. Virus virus-like particles (VLP, noninfectious particles) provide versatile platforms nanoscale bioengineering. Study of capsid...
Objective: The aim of the study is to describe morphology associated with development osteoarthritis (OA) in three different age groups. These data will contribute defining early and late hip OA. Methods: We studied 400 hips 377 patients who had undergone primary THA due idiopathic Three groups were compared: group 1 (n = 147), younger patients, aged up 60 years; 2 155), between 61 74 3 98), 75 or over. Five independent researchers measured angles mean values used build a database. Results:...