A5101973293- Animal Disease Management and Epidemiology
- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- Virus-based gene therapy research
- Virology and Viral Diseases
- Viral Infections and Immunology Research
- CRISPR and Genetic Engineering
- Viral gastroenteritis research and epidemiology
- Evolution and Genetic Dynamics
- Viral Infections and Outbreaks Research
- Animal Virus Infections Studies
- Plant Virus Research Studies
- Cancer Research and Treatments
- Vector-borne infectious diseases
- Viral Infectious Diseases and Gene Expression in Insects
- interferon and immune responses
- Immune Response and Inflammation
- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
- HIV Research and Treatment
- Poxvirus research and outbreaks
- Insect and Pesticide Research
- Immune Cell Function and Interaction
- Insect and Arachnid Ecology and Behavior
- Hepatitis B Virus Studies
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria
2016-2025
Consejo Superior de Investigaciones Científicas
2001-2025
Centro de Investigación en Sanidad Animal
2011-2023
Ipsen (France)
2021
Universidad Autónoma de Madrid
1999-2018
Centro Nacional de Biotecnología
2018
Centre de Recerca en Sanitat Animal
2017
Centro de Biología Molecular Severo Ochoa
1998-2016
The Pirbright Institute
2016
The University of Melbourne
2008-2015
ABSTRACT Arenaviruses include several important human pathogens, and there are very limited options of preventive or therapeutic interventions to combat these viruses. An off-label use the purine nucleoside analogue ribavirin (1- β - d -ribofuranosyl-1- H -1,2,4-triazole-3-carboxamide) is only antiviral treatment currently available for arenavirus infections. However, mechanism action against arenaviruses remains unknown. Here we document that mutagenic prototypic lymphocytic...
Peste des petits ruminants (PPR) is a highly contagious disease of small caused by the Morbillivirus peste virus (PPRV). Two recombinant replication-defective human adenoviruses serotype 5 (Ad5) expressing either immunogenic fusion protein (F) or hemagglutinin (H) from PPRV were used to vaccinate sheep intramuscular inoculation. Both adenovirus vaccines elicited PPRV-specific B- and T-cell responses. Thus, neutralizing antibodies detected in sera immunized sheep. In addition, we significant...
Arboviruses cause acute diseases that increasingly affect global health. We used bluetongue virus (BTV) and its natural sheep host to reveal a previously uncharacterized mechanism by an arbovirus manipulate immunity. Our study shows BTV, similarly other antigens delivered through the skin, is transported rapidly via lymph peripheral nodes. Here, BTV infects disrupts follicular dendritic cells, hindering B-cell division in germinal centers, which results delayed production of high affinity...
Bluetongue virus (BTV) is a non-enveloped dsRNA that causes haemorrhagic disease mainly in sheep. It an economically important Orbivirus of the Reoviridae family. In order to estimate importance T cell responses during BTV infection, it essential identify epitopes targeted by immune system. present work, we selected potential (3 MHC-class II-binding and 8 I binding peptides) for C57BL/6 mouse strain from BTV-8 non-structural protein NS1, using H2b-binding predictive algorithms. Peptide...
Bluetongue virus (BTV) is an economically important Orbivirus of the Reoviridae family that causes a hemorrhagic disease in ruminants. Its control has been achieved by inactivated-vaccines have proven to protect against homologous BTV challenge although unable induce long-term immunity. Therefore, more efficient strategy needs be developed. Recombinant adenovirus vectors are lead vaccine candidates for protection several diseases, mainly because their potency potent T cell Here we report...
Abstract Cyclic GMP-AMP synthase (cGAS) is a DNA sensing cellular receptor that induces IFN-I transcription in response to pathogen and host derived cytosolic can limit the replication of some RNA viruses. Some viruses have nonetheless evolved mechanisms antagonize cGAS sensing. In this study, we evaluated interaction between Bluetongue virus (BTV), prototypical dsRNA Orbivirus genus Sedoreoviridae family, cGAS. We found mitochondrial damage accumulation cytoplasm infected cells. addition,...
Background/Objectives: Bluetongue virus (BTV) is an emerging arbovirus causing significant economic losses in the ruminant industry. Current vaccines offer limited cross-protection against heterologous serotypes and do not enable differentiation between infected vaccinated animals (DIVA). Subunit-based provide a potential DIVA-compatible solution. This study aimed to develop vaccination protocol expressing BTV structural proteins VP7 or VP2 using antibiotic-resistance-free DNA plasmids...