A5067919485- Pneumocystis jirovecii pneumonia detection and treatment
- Systemic Lupus Erythematosus Research
- Immune Response and Inflammation
- Neonatal Respiratory Health Research
- Plant biochemistry and biosynthesis
- NF-κB Signaling Pathways
- Essential Oils and Antimicrobial Activity
- Blood disorders and treatments
- Animal Nutrition and Physiology
- IL-33, ST2, and ILC Pathways
- Heme Oxygenase-1 and Carbon Monoxide
- Pneumonia and Respiratory Infections
- Pediatric health and respiratory diseases
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- Inflammasome and immune disorders
- Mesenchymal stem cell research
- Antibiotic Resistance in Bacteria
- Immune Cell Function and Interaction
- Legionella and Acanthamoeba research
- Sesquiterpenes and Asteraceae Studies
Sun Yat-sen University
2024
Louisiana State University
2019-2024
Hebei Medical University
2024
Second Hospital of Hebei Medical University
2024
Research Institute of Animal Husbandry
2023
Objective The efficacy of sirolimus in treating severe or refractory systemic lupus erythematosus (SLE) has been confirmed by small-scale clinical trials. However, few studies focused on mild moderate SLE. Therefore, this study we elucidated add-on patients with Methods Data 17 consecutive SLE were retrospectively collected. Disease Activity Index-2000 (SLEDAI-2K), manifestation, laboratory data and peripheral T lymphocyte subsets cytokines collected before 6 months after treatment. cell...
Pyroptosis, an innate immune response, plays a crucial role in the pathological process of inflammatory diseases. Although pyroptosis blockade is considered potential therapeutic strategy, no ideal candidate drug has been identified. The natural product Chojaponilactone B (CJB) demonstrated anti-inflammatory effects, but its macrophage not studied. This study aimed to investigate effect and mechanism CJB inhibiting pyroptosis. Using LPS/ATP-induced THP-1 model, we found that significantly...
Sarcanoids A and B (1 2), two new lindenane-type sesquiterpenoid dimers with a γ-hydroxysenecioate moiety at C-15′, were isolated from the ethyl acetate extract of Sarcandra glabra. The structures elucidated by extensive analysis spectroscopic data, their absolute configurations determined single-crystal X-ray crystallography. Compounds 1 2 showed moderate inhibitory activities on nitric oxide (NO) production induced lipopolysaccharide (LPS) in RAW264.7 macrophages.