A5028399673- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Reproductive System and Pregnancy
- Cancer-related molecular mechanisms research
- Studies on Chitinases and Chitosanases
- Immune Response and Inflammation
- Genomics and Phylogenetic Studies
- Cancer-related gene regulation
- Synthetic Organic Chemistry Methods
- RNA Research and Splicing
- Advanced Synthetic Organic Chemistry
- Immunodeficiency and Autoimmune Disorders
- RNA and protein synthesis mechanisms
- Enzyme Production and Characterization
- Calcium Carbonate Crystallization and Inhibition
- Chemical synthesis and alkaloids
University of Hawaiʻi at Mānoa
2023-2024
Johns Hopkins University
2023-2024
Dezhou University
2024
Peking University
2013-2016
Peking University People's Hospital
2013-2016
Tetraploid oysters are used to cross with diploids produce triploid that have become an important part of the oyster aquaculture industry worldwide. Although most tetraploid artificially induced autotetraploids, allotetraploids can be produced between closely related species, providing new opportunities for polyploid breeding and studying genome interactions. Using PacBio sequencing, Illumina high-throughput chromosome conformation capture scaffolding, we assembled first high-quality...
Small nucleolar RNAs (snoRNAs) constitute a class of intron-derived non-coding ranging from 60 to 300 nucleotides. Canonically localized in the nucleolus, snoRNAs play pivotal role RNA modifications and pre-ribosomal processing. Based on types they involve, such as methylation pseudouridylation, are classified into two main families—box C/D H/ACA snoRNAs. Recent investigations have revealed unconventional synthesis biogenesis strategies snoRNAs, indicating their more profound roles...
HLA‐DRB1 *07:01:19 differs from DRB1 *07:01:01:01 by a single nucleotide substitution at position 261 of exon 2.
HLA ‐A*02: 622N differs from A *02:07:01 by a single nucleotide substitution at position 420 of exon 3.
The novel HLA‐A*02:425 allele differs from A*02:121 by a single nucleotide substitution at position 601 of exon 3.
Abstract HLA‐C*15:96Q differs from C*15:02:01:01 by a single‐nucleotide substitution at position 164 of exon 3.
The novel HLA‐DRB1 *14:143 allele differs from DRB1 *14:10 by two nucleotide substitutions at positions 344 and 345 of exon 2.
Abstract Establishing global footprint of altered m6A mRNA is a unique method to identify the new prognostics biomarkers. Altered N6-methyladenosine(m6A) RNA methylation regulates cancer progression with uncharacterized mechanism. Here, we present novel link between modification on 5’-UTR SIM2-SV contribution in colorectal progression. MeRIP and RNA-seq data from 68 fresh frozen CRC samples revealed 13,843 methylated peaks found highest chromosomes 1, 2, 3. Analysis uncovered 119 overlapping...
HLA‐DRB1 *08:45:02 differs from DRB1 *08:30:01 by a single nucleotide substitution at position 227 of exon 2.
Fragments derived from small RNAs such as nucleolar hold biological relevance. However, they remain poorly understood, calling for more comprehensive methods analysis. We developed sRNAfrag, a standardized workflow and set of scripts to quantify analyze sRNA fragmentation any biotype. In benchmark, it is able detect loci mature microRNAs fragmented precursors and, utilizing multi-mapping events, the conserved 5' seed sequence miRNAs which we believe may extraoplate other RNA fragments. The...