A5113014965- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Asthma and respiratory diseases
- Psoriasis: Treatment and Pathogenesis
- Organic and Inorganic Chemical Reactions
- RNA Interference and Gene Delivery
- Inhalation and Respiratory Drug Delivery
- Complement system in diseases
- TGF-β signaling in diseases
- Mesenchymal stem cell research
- Pharmaceutical studies and practices
- Pharmacological Effects and Assays
- Synthesis and Biological Evaluation
- Inflammatory mediators and NSAID effects
- Hemodynamic Monitoring and Therapy
- SARS-CoV-2 and COVID-19 Research
- Dermatology and Skin Diseases
- Renal Transplantation Outcomes and Treatments
- Eicosanoids and Hypertension Pharmacology
- Xenotransplantation and immune response
- Respiratory viral infections research
- Influenza Virus Research Studies
- Advanced biosensing and bioanalysis techniques
- Pulmonary Hypertension Research and Treatments
- Cell Adhesion Molecules Research
Wave Life Sciences (United States)
2021-2023
Insmed (United Kingdom)
2016
Merck & Co., Inc., Rahway, NJ, USA (United States)
2012-2015
Johnson & Johnson (United States)
2006
Mitsubishi Corporation (Japan)
2002
Instytut Farmaceutyczny
1999
May Institute
1998
University of Chicago
1994-1998
Medical University of South Carolina
1990
Type 1 diabetes mellitus is a chronic autoimmune disease caused by the pathogenic action of T lymphocytes on insulin-producing beta cells. Previous clinical studies have shown that continuous immune suppression temporarily slows loss insulin production. Preclinical suggested monoclonal antibody against CD3 could reverse hyperglycemia at presentation and induce tolerance to recurrent disease.
Background. HuOKT3γ1(Ala-Ala) is a genetically-engineered derivative of the parental murine OKT3 monoclonal antibody, in which six complementarity-determining regions have been grafted within human IgG1 mAb, and whose CH2 region has altered by site-directed mutagenesis to alter FcR-binding activity, thereby eliminating T cell activation properties. This report describes results phase I trial huOKT3γ1(Ala-Ala) treatment acute renal allograft rejection. Methods. Acute rejection kidney...
OKT3, a mouse anti-human CD3 mAb, is potent immunosuppressive agent used in clinical transplantation to prevent or treat allograft rejection. Associated with this therapy the systemic release of several cytokines that result series adverse side effects. This dependent on cross-linking mediated by OKT3 between T cells and Fc gamma R-bearing cells. To generate an mAb reduced activating properties as compared we have transferred complementary determining regions onto human IgG frameworks then...
Objective: The primary objective of this study revolves around the development a population pharmacokinetic (PPK) model for vancomycin in neonatal subjects, with providing theoretical basis judicious therapeutic interventions. Methods: In study, retrospective collection encompassed 75 patients, contributing to total 89 blood concentration monitoring datasets. establishment PPK is carried out utilizing nonlinear mixed effects methodology. was constructed employing one‐compartment proportional...
OKT3 is a murine monoclonal antibody which recognizes an epitope on the epsilon-subunit within human CD3 complex. possesses potent immunosuppressive properties in vivo and has been proven effective treatment of renal, heart liver allograft rejection. Despite its efficacy, significant problems remain associated with therapy, i.e. T-cell activation anti-murine response. To address problem response we have constructed humanized versions OKT3. One derivatives, gOKT3-7 incorporating...
Chondrogenic promotion by rhGDF5 with or without rhTGFbeta3 was studied in pellet culture of human mesenchymal stem cells (HMSCs). A synergy between and observed promoting chondrogenesis. rhBMP2, rhBMP6, rhBMP7 rhTGFbeta1 were further tested showed the same effect. To explore mechanism, expression TGFbetatype I II receptors, ALK5, ALK2, ALK3, ALK6, TGFbetaRII, BMPRII, ActRII studied. ALK6 increase treatment. protein also rhTGFbeta3. rhTGFbeta1/rhTGFbeta3 induced up-regulation inhibited...
<b>Background:</b> Inhaled treprostinil (TRE [Tyvaso®]), a vasodilator for pulmonary arterial hypertension (PAH), must be administered QID and is associated with cough. C16TR Inhalation (INS1009) lipid nanoparticle formulation of prodrug (hexadecyltreprostinil) that being developed to provide QD dosing PAH. converted free hexadecanol. Preclinical studies demonstrated single-dose inhalation well tolerated produces long-acting vasodilation sustained levels in plasma lungs. <b>Objectives:</b>...
<b>Background:</b> Inhaled treprostinil (TRE [Tyvaso<sup>®</sup>]) is a QID vasodilator indicated for pulmonary arterial hypertension (PAH). C16TR Inhalation (INS1009) lipid nanoparticle formulation of prodrug (hexadecyltreprostinil), under development to provide QD or BID dosing PAH. converted free and hexadecanol. Animal studies found that single-dose inhalation resulted in sustained levels plasma lungs. <b>Objectives:</b> First-in-human study determine the MTD single dose characterize PK...
Transplantation is published monthly and the most cited influential journal in field, with more than 25,000 citations per year. The celebrated its 50th year 2016. has been trusted source for extensive timely coverage of important advances transplantation. Editors Editorial Board are an international group research clinical leaders that includes many pioneers representing a diverse range areas expertise. This capable editorial team provides thoughtful thorough peer review, delivers rapid,...
<h3>Background</h3> Huntington's disease is caused by the expansion of CAG-repeats (≥36 repeats) in at least one copy <i>HTT</i> gene that leads to expression mutant HTT (mHTT) protein. The unaffected encodes wild-type (wtHTT) protein, which supports many processes important for health and function CNS. <h3>Aims</h3> Wave has developed WVE-003, an investigational stereopure oligonucleotide designed selectively reduce mHTT mRNA while preserving wtHTT targeting a single nucleotide...