A5089118340- Characterization and Applications of Magnetic Nanoparticles
- Geomagnetism and Paleomagnetism Studies
- Electrical and Bioimpedance Tomography
- Microfluidic and Bio-sensing Technologies
- Magnetic properties of thin films
- Minerals Flotation and Separation Techniques
- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- Cardiovascular Health and Disease Prevention
- Advanced X-ray and CT Imaging
- Muscle Physiology and Disorders
- Atomic and Subatomic Physics Research
- Nanoparticle-Based Drug Delivery
- Blood properties and coagulation
- Particle Dynamics in Fluid Flows
- Atmospheric aerosols and clouds
- Cardiomyopathy and Myosin Studies
- Peripheral Artery Disease Management
- Advanced biosensing and bioanalysis techniques
- Cardiac tumors and thrombi
- Radiopharmaceutical Chemistry and Applications
- Radioactive Decay and Measurement Techniques
- Magnetic and Electromagnetic Effects
- Clinical practice guidelines implementation
- Health Systems, Economic Evaluations, Quality of Life
Wave Life Sciences (United States)
2023
Klinik und Poliklinik für Nuklearmedizin
2011-2022
Dorma (Germany)
2021-2022
University of Lübeck
2011-2021
University Hospital Schleswig-Holstein
2011-2018
To evaluate the feasibility of different approaches instrument visualization for cardiovascular interventions guided by using magnetic particle imaging (MPI).Two balloon (percutaneous transluminal angioplasty) catheters were used. The was filled either with diluted superparamagnetic iron oxide (SPIO) ferucarbotran (25 mmol per liter) or sodium chloride. Both inserted into a vessel phantom that oppositional to content chloride SPIO liter). In addition, administration 1.4-mL bolus pure (500...
Magnetic Particle Imaging (MPI) is able to provide high temporal and good spatial resolution, signal-to-noise ratio sensitivity. Furthermore, it a truly quantitative method as its signal strength proportional the concentration of tracer, superparamagnetic iron oxide nanoparticles (SPIOs). Because that, MPI proposed be promising future for cardiovascular imaging. Here, an interesting application may quantification vascular pathologies like stenosis by utilizing proportionality SPIO strength....
Magnetic particle imaging (MPI) uses magnetic fields to visualize the spatial distribution of superparamagnetic iron oxide nanoparticles (SPIOs). Guidance cardiovascular interventions is seen as one possible application MPI. To safely guide interventions, vessel lumen well all required interventional devices have be visualized and discernible from each other. Until now, different tracer concentrations were used for discerning blood in MPI, because only type SPIO could imaged at a time....
Magnetic particle imaging (MPI) is able to provide high temporal and good spatial resolution, signal noise ratio sensitivity. Furthermore, it a truly quantitative method as its strength proportional the concentration of tracer, superparamagnetic iron oxide nanoparticles (SPIOs), over wide range practically relevant concentrations. Thus, MPI proposed promising future for guidance vascular interventions. To implement this, devices such guide wires catheters have be discernible in MPI, which...
Magnetic particle imaging has emerged as a new technique for the visualization and quantification of superparamagnetic iron oxide nanoparticles. It seems to be very promising application cardiovascular interventional radiology. A prerequisite interventions is artifact-free required instruments implants. Various commercially available catheters, guide wires, catheter experimentally coated with nanoparticles were tested regarding their signal characteristics using magnetic spectroscopy...
Background: Magnetic particle imaging (MPI) uses magnetic fields to visualize superparamagnetic iron oxide nanoparticles (SPIO). Today, Resovist ® is still the reference SPIO for MPI. The objective of this study was evaluate in vivo blood half-life two different types (one from Bayer Pharma AG, and one I'rom Pharmaceutical Co Ltd) Methods: A concentration 50 µmol/kg injected into ear artery ten New Zealand White rabbits. Five animals received distributed by Ltd five AG. Blood samples were...
Magnetic particle imaging (MPI) recently emerged as a new tomographic method directly visualizing the amount and location of superparamagnetic iron oxide particles (SPIOs) with high spatial resolution. To fully exploit performance MPI, specific requirements are demanded on SPIOs. Most important, sufficiently number detectable harmonics receive signal spectrum is required. In this study, an assessment commercial oxide-based MRI contrast agents carried out, result compared that...
Magnetic particle imaging (MPI) has emerged as a new method with the potential of delivering images high spatial and temporal resolutions free ionizing radiation. Recent studies demonstrated feasibility differentiation between signal-generating non-signal-generating devices in Particle Spectroscopy (MPS) visualization commercially available catheters guide-wires MPI itself. Thus, seems to be promising tool for cardiovascular interventions. Several were tested this study regarding heating....
Endovascular stents are medical devices, which implanted in stenosed blood vessels to ensure sufficient flow. Due a high rate of in-stent re-stenoses, there is the need noninvasive imaging method for early detection stent occlusion. The evaluation lumen with computed tomography (CT) and magnetic resonance (MRI) limited by material-induced artifacts. purpose this work investigate potential tracer-based modality particle (MPI) visualization quantification.In vitro study, 21 endovascular were...
Abstract Purpose To evaluate heating of a redilatable stent for the treatment aortic coarctation in neonates and small children new imaging modality magnetic particle established resonance imaging. Materials Methods The cobalt-chromium (BabyStent, OSYPKA AG, Rheinfelden, Germany) has design which allows redilatation adjustment diameter from 6 to 16 mm use coarctation. loses its radial integrity while opening at predetermined breaking points 14 or mm, respectively. We measured temperature...
Three Litz wires have been used in parallel order to decrease the layer voltage down 4 kV and coil 8 kV. A two millimeter thick epoxy plate has glued between each layer, prevent any electrical breakdown layers. special minimize inner temperature of coil, which reached 180°C with a dissipated power 5.2 kW. The use wire leads currents having different phase angle every be corrected.
The highest spectral MPI signal was measured directly after Resovist <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">®</sup> administration (3,21*10 xmlns:xlink="http://www.w3.org/1999/xlink">−9</sup> Am2Hz xmlns:xlink="http://www.w3.org/1999/xlink">−1</sup> ). After application of the decreased to 39.7 % within 5 minutes and 20.5 12.1 10 15 minutes, respectively (see Fig. 1). Within 30 below background noise level.
The purpose of this work was to develop instrument markers that are visible in both magnetic particle imaging (MPI) and resonance (MRI). were based on two different nanoparticle types (synthesized in-house KLB commercial Bayoxide E8706). Coatings containing one fabricated measured with a spectrometer (MPS) estimate their MPI performance. then applied segment nonmetallic guidewire. Imaging experiments conducted using commercial, preclinical scanner 1 tesla MRI system. image reconstruction...