A5055494376- RNA regulation and disease
- RNA and protein synthesis mechanisms
- Data Mining Algorithms and Applications
- Data Quality and Management
- Privacy-Preserving Technologies in Data
- Microtubule and mitosis dynamics
- Semantic Web and Ontologies
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Cancer-related Molecular Pathways
Peking University
2018-2022
Stanford University
2018
The MRE11-RAD50-NBS1 (MRN) complex is well known for participating in DNA damage response pathways all phases of cell cycle. Here, we show that MRN constitutes a mitosis-specific complex, named mMRN, with protein, MMAP. MMAP directly interacts MRE11 and required optimal stability the during mitosis. colocalizes mitotic spindles, MMAP-deficient cells display abnormal spindle dynamics chromosome segregation similar to MRN-deficient cells. Mechanistically, both are hyperphosphorylated by...
We introduce Rock, a system for cleaning relational data. Rock implements framework that unifies machine learning (ML) and logic deduction by embedding ML classifiers in rules as predicates. In unified process, it identifies tuples refer to the same real-world entity, catches semantic inconsistencies among entities, deduces timeliness of attribute values imputes missing possibly extracting data from knowledge graphs. That is, conducts entity resolution, conflict incomplete information...
We demonstrate Rock, a system for cleaning relational data. Rock highlights the following unique features: (1) it extends logic rules by embedding machine learning models as predicates, to benefit from both ML and deduction; (2) supports entity resolution, conflict timeliness deduction missing data imputation in unified process; (3) provides parallelly scalable algorithms rule discovery, error detection correction, batch incremental modes. will its (a) easy-to-use interface, (b) scalability...