Background: Catastrophic antiphospholipid syndrome (CAPS), a rare thrombotic manifestation of (APS), carries high mortality. Bilateral adrenal hemorrhage (BAH), an unusual com-plication APS, is seldom reported. This case highlights presen-tation bilateral haemorrhage due to probable CAPS second-ary systemic lupus erythematosus (SLE). Methods: A 57-year-old diabetic female presented with hypovolemic shock, abdominal pain, and vomiting. Clinical evaluation, imaging (CECT abdomen), laboratory...

Glycated hemoglobin (HbA1c) can be altered in different conditions. We hypothesize that HbA1c levels may change due to thyroid status, possibly changes red blood cell (RBC) turnover.

Renal tubular disorders are an important cause of refractory rickets. Wilson's disease, inherited disorder copper metabolism has varied presentations. We present a case rickets due to Fanconi's syndrome attributable disease. An adolescent girl presented with pain in the hip and knee joints knock-knee deformity since six years. She had received multiple doses cholecalciferol little improvement. There was no history seizures, polyuria, jaundice, intake drugs, or similar complaints family....

Polycystic ovary syndrome (PCOS) is associated with insulin resistance and elevated risk of cardiovascular disease diabetes. Chronic inflammation has been observed in PCOS several studies but there also opposing evidence a dearth research Indians.To estimate chronic find its relationship appropriate anthropometric biochemical parameters.Chronic was assessed 30 women (Group A) healthy controls B) highly sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6), tumour necrosis factor alpha...

A 6-year-old Indian girl presented with progressive bowing of both legs for the last 4.5 years (figure 1). She was diagnosed as having rickets by her primary care physician and treated multiple courses vitamin D, without effect. Her immediate postnatal history developmental milestones (language, social motor) were normal she started walking support at 1 year. had been breast fed exclusively until 6 months on an age-appropriate average non-vegetarian diet adequate milk intake. The deformity...

Pseudoacromegaly or acromegaloidism is a clinical condition characterised by physical signs suggestive of excess growth hormone (GH) but with normal functioning the GH—insulin-like factor-1 (IGF-1) axis. A number disease entities, such as pachydermoperiostitis, severe insulin resistance, familial mandibular prognathism, acromegaloid facial appearance and chronic intake phenytoin minoxidil, are known to be associated pseudoacromegaly. When features acromegaly baseline dynamic GH IGF1 levels,...

Isolated FSH deficiency due to mutations in the gene for β-subunit of is an extremely rare autosomal recessive disease which only eleven cases have been reported so far. The clinical features include absent breast development and primary amenorrhea females azoospermia with normal testosterone levels males. In this study we report two Kashmiri sisters born native consanguineous parents failure onset puberty. Hormonal evaluation revealed undetectable serum estradiol high LH. Genetic analysis...

Germ cell tumors may lead to incomplete isosexual male precocity and are commonly located in the pineal gland. Germinomas of basal ganglia almost always unilateral precocious puberty is a rare manifestation them. We report 9.5-year-old boy who presented with due bilateral germinoma.

Thyroid associated orbitopathy, although seen most commonly with thyrotoxicosis, is also known to occur in primary hypothyroidism. Myasthenia gravis an autoimmune condition established association thyroid disease. We report the case of a patient who presented recent onset unilateral ptosis that was fatigable history proptosis since year. On examination, she had goiter, bilateral proptosis, restriction upward gaze and adduction both eyes normal pupils. Investigations revealed hypothyroidism...

Ectopic neurohypophysis (EN) is found in nearly half of children with growth hormone deficiency (GHD). Rathke's cyst (RC) uncommon and when present, hypopituitarism them. We present a fourteen half-year-old girl severe short stature delayed puberty who on evaluation was to have GHD, secondary hypocortisolism, hypogonadism. Imaging revealed hypoplastic anterior pituitary, stalk agenesis, EN at tuber cinereum intrapituitary RC. This perhaps the first report simultaneous occurrence RC, which...

Objective: To present a rare case of gigantism. Case Report: A 25-year-old lady presented with increased statural growth and enlarged body parts noticed since the age 14 years, primary amenorrhea, frontal headache for last 2 years. She has also been suffering from non-inflammatory low back pain progressive kyphosis in knees, ankles, elbows 5 There was no history visual disturbance, vomiting, galactorrhoea, cold intolerance. had siblings. Family non-contributory. Blood pressure normal. Height...

Background and objective: Dilated cardiomyopathy (DCM) is a prevalent form of heart failure results in dilation disruption heart. Most strikingly majority the DCM cases do not have any identified etiology, hence known as idiopathic (IDCM). Our study aimed to investigate cross-talk between leukocytes cardiomyocytes terms cardiac inflammation stress response IDCM. Methods: 60 IDCM patients age sex matched healthy volunteers were recruited this based on New York Heart Association (NYHA)...

Objectives: To determine the Bone Mineral Density (BMD) of paediatric Systemic Lupus Erythematosus (pSLE) and Juvenile Idiopathic Arthritis (JIA) patients its association with predefined variables.Method: This was a cross-sectional study involving consecutive pSLE JIA attending rheumatology clinic. Healthy age sex matched controls were selected from neighbouring schools. BMD assessed at lumbar spine by Dual Energy X-ray Absorptiometry (DEXA) scan expressed as Z-score. Its correlation...

Background. Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease. Rheumatic diseases are a major cause of chronic illness in children around world. SLE further prevalent inflammatory illness. Aims and objectives. To study different growth parameters pediatric patients attending rheumatology clinic, to compare with age sex matched controls among types patients. Method. Different SMI (for above 9 years) were recorded for OPD having disease duration more than one year....

Proximal renal tubular acidosis (pRTA) is characterized by a defect in the ability of proximal convoluted tubule to reabsorb bicarbonate. The biochemical hallmark pRTA hyperchloremic metabolic with normal anion gap, accompanied appropriate acidification urine (simultaneous pH <5.3). Isolated defects bicarbonate transport are rare, and more often associated Fanconi syndrome (FS), which urinary loss phosphate, uric acid, glucose, amino acids, low-molecular-weight proteins, Children may present...

Patients with osteomalacia have a low bone mineral density (BMD) and are often misdiagnosed as osteoporosis. A marked increase in BMD is noticed following successful treatment of osteomalacia. The biochemical hallmark tumour-induced (TIO) hypophosphatemia. TIO severe hypophosphatemic dual-energy X-ray absorptiometry may demonstrate BMD. Surgical removal the phosphatonin-secreting lesion restores serum phosphate, corrects associated dramatic We report two patients BMD, who were treated oral...

Allgrove's syndrome is a rare autosomal-recessive disorder with only about 70 cases reported thus far and characterized by alacrima, achalasia, ACTH insensitivity among other clinical features. However, it has widely variable presentation, which may result in such remaining undiagnosed.To report patient impending to highlight the importance of suspicion diagnosing same.A 2.5-year-old girl was diagnosed on basis barium swallow study, Schirmer's test, hormonal evaluation.A girl, born...

Tuberculosis is the most common cause of Addison's disease in India. The exact status adrenal reserve tuberculosis still an enigma and recovery function unpredictable.We report a case with pre-Addisonian state unchanged size after 1 year treatment.A 31-year patient was diagnosed treated anti tubercular drugs (ATDs) steroid.A male, presented fever weight loss for 3½ months anorexia, nausea, hyperpigmentation skin, buccal mucosa weakness past h/o adequately pulmonary at 3 years age. On...

Objective: 17-α-Hydroxylase deficiency (17-OHD) is a very rare disorder of adrenal and gonadal steroidogeneis. The patient usually presents as phenotypic female with hypertension, hypokalemia, delayed puberty due to hypergonadotropic hypogonadism. Karyotype may be 46,XX or 46,XY. Timely diagnosis leads effective management the appropriate screening family members.Methods: Case report review literature.Results: A 24-year-old woman presented primary amenorrhea poor development secondary sexual...