A5008023966- Virus-based gene therapy research
- Stress Responses and Cortisol
- Platelet Disorders and Treatments
- CRISPR and Genetic Engineering
- Infant Development and Preterm Care
- Homelessness and Social Issues
- Immunotoxicology and immune responses
- Infant Health and Development
- Fatty Acid Research and Health
- Carbohydrate Chemistry and Synthesis
- Glycosylation and Glycoproteins Research
- Complement system in diseases
- Polymer Surface Interaction Studies
- Proteoglycans and glycosaminoglycans research
- Animal Genetics and Reproduction
- Cancer Research and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Hematopoietic Stem Cell Transplantation
- Eicosanoids and Hypertension Pharmacology
- Skin and Cellular Biology Research
- Child Abuse and Trauma
- Blood transfusion and management
- Pediatric Pain Management Techniques
- Indigenous Studies and Ecology
- Dermatology and Skin Diseases
Association of Women's Health Obstetric and Neonatal Nurses
2020
National Institutes of Health
2020
Sigma Theta Tau International
2020
National Institute of Nursing Research
2020
The Ohio State University
2004-2018
Simpson University
1995
University of Michigan
1995
University of Massachusetts Chan Medical School
1991
High levels of circulating proinflammatory cytokines are characteristic inflammaging, a term coined to describe age-related chronic systemic inflammation involved in the etiology many disorders including nonhealing wounds. Some studies have shown that supplementing diets with n-3 polyunsaturated fatty acids (eicosapentaenoic acid [EPA] and docosahexaenoic [DHA]) lowers key associated inflammaging. However, findings from few focused exclusively on older adults inconclusive. As such, objective...
The hormone cortisol is typically assessed in saliva, serum, or urine samples. More recently, has been successfully extracted from hair, including humans. advantage of hair concentration that it reflects a retrospective representation hypothalamic-pituitary-adrenal (HPA) axis function over time, much like hemoglobin A1C represents glycemic control. However, obtaining samples can be challenging, due to the cultural beliefs and care practices minority participants. For example, African...
A method to produce clinically useful platelets in vitro would help overcome the frequent shortages, donor deferrals, disease transmission, and alloimmunization with volunteer donor-derived platelets. Using CD34 positively selected cord blood cells, we investigated ways increase platelet quality yield a three-dimensional modular perfusion bioreactor system. We found two- threefold numbers produced only when early phases of culture process were carried out at 5% oxygen, versus 20% oxygen was...
Oxytocin (OT), a neuropeptide produced primarily in the hypothalamus, is associated with both critical physiological and psychological processes, particularly stress feelings of affiliation. Increasingly, researchers are seeking ways to reliably incorporate OT as an outcome biomarker clinical research. Previously, levels were measured plasma or urine. Recently, have this saliva, when conducting research community settings. In spite increased interest use salivary research, procedures for...
Background Hair cortisol is a measure of chronic or repeated hypothalamic–pituitary–adrenal axis activation in response to physical psychological stressors. has been successfully used as stress adults and children; however, its use valid preterm infants limited by challenges measuring the low mass samples collectable from these infants. Objectives The purpose this report present novel protocol for measurement hair very samples. Methods Small changes were made previously published protocols....
Investigations of chronic physiologic stress measured by hair cortisol are rapidly expanding among community samples adolescents and adults. However, research examining youth experiencing homelessness is nascent despite the youths' increased risk for adverse exposures subsequent impaired mental health.This paper aimed to examine feasibility collecting measuring diverse gain an understanding variation in participation.Analysis survey participation data from three pilot studies was conducted....
The ACE System is a potent biological engineering system consisting of mammalian artificial chromosome engineered with multiple site-specific integration sites, expression-optimized shuttle vectors to specifically transfer genes, and proprietary integrase catalyze specific incorporation payload onto the ACE. ACEs are promising gene delivery vehicles for gene-based cell therapies as they stably maintained, non-integrating, autonomously replicating, easily isolated high purities by flow...